Posted: November 20th, 2008, 1:43pm CET by addebook
Medicinal Protein Engineering
Medicinal Protein Engineering
By Yury E. Khudyakov
Publisher: CRC
Number Of Pages: 592
Publication Date: 2008-11-14
ISBN-10 / ASIN: 0849373689
ISBN-13 / EAN: 9780849373688
Binding: Hardcover
AnAll-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field
From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.
Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.
Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases
Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.
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Posted: November 20th, 2008, 1:42pm CET by addebook
Drug Truths: Dispelling the Myths About Pharma R & D
by John L. LaMattina
Drug Truths: Dispelling the Myths About Pharma R & D
By John L. LaMattina
Publisher: Wiley
Number Of Pages: 136
Publication Date: 2008-11-10
ISBN-10 / ASIN: 0470393181
ISBN-13 / EAN: 9780470393185
Binding: Paperback
This book answers the questions about the process and costs of pharmaceutical R & D in a compelling narrative focused on the discovery and development of important new medicines. It gives an insider’s account of the pharmaceutical industry drug discovery process, the very real costs of misperceptions about the industry, the high stakes–both economic and scientific–of developing drugs, the triumphs that come when new compounds reach the market and save lives, and the despair that follows when new compounds fail. In the book, John LaMattina, former president of Pfizer Global Research and Development, weaves themes critical to a vital drug discovery environment in the context. This is a story that Dr. LaMattina is uniquely qualified to tell.
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Posted: November 20th, 2008, 1:41pm CET by addebook
Pharmacology, Doping and Sports: A Complete Scientific Guide for Athletes, Coaches, Physicians, Scientists and Administrators
by Jean L. Fourcr
Pharmacology, Doping and Sports: A Complete Scientific Guide for Athletes, Coaches, Physicians, Scientists and Administrators
By Jean L. Fourcr
Publisher: Routledge
Number Of Pages: 240
Publication Date: 2008-10-14
ISBN-10 / ASIN: 0415428459
ISBN-13 / EAN: 9780415428453
Binding: Hardcover
The work of dope testers is constantly being obstructed by the development of ever harder to trace new forms of banned substances. Organisations such as the World Anti-Doping Association and the United States Anti-Doping Agency are pioneering cutting-edge techniques designed to keep competition at the highest level fair and safe, and must ensure that their drug testing laboratories adhere to the highest scientific standards. In “Pharmacology, Doping and Sports” these techniques and procedures are explained by the anti-doping experts who practice them.Broad-ranging in scope, this book examines the effects of performance-enhancing substances on the athlete’s health; the role of anti-doping procedures as an ethical question, and explains the background to, and the emergence of, the anti-doping movement. The book also offers in-depth analysis of key scientific matters, such as: standard analytical and diagnostic tests for sports doping; regulatory standards for laboratory proficiency; common performance-enhancing techniques such as anabolic and designer steroids, blood doping, growth hormones, and gene doping; and, carbon-isotope ratio testing. Written by some of the world’s leading authorities on the science of sports doping, “Pharmacology, Doping and Sports” provides an invaluable study of up-to-the-minute anti-doping techniques. This book is essential reading for all sports scientists, coaches, policy-makers, students and athletes interested in the science or ethics of doping in sport.
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Concepts In Clinical Pharmacokinetics
Concepts In Clinical Pharmacokinetics
By Joseph T. Dipiro, William J. Spruill, William E. Wade, Robert A. Blouin, Jane M. Pruemer
Publisher: American Society of Health-System Pharmacists
Number Of Pages: 230
Publication Date: 2005-10-30
ISBN-10 / ASIN: 1585281247
ISBN-13 / EAN: 9781585281244
Binding: Paperback
Programmed manual presents basic pharmacokinetic concepts and procedures. Material relates to individualization of drug dose regimens. Topics include pharmacokinetics, half-life, elimination rate, AUC, two-compartment models, drug elimination process, vancomycin, and more. For pharmacists and practitioners. Softcover. DNLM: Pharmacokinetics-Programmed Instruction.
Summary: A Nice Introductory Book
Rating: 4
Let’s me first say, my background is physical chemistry and analytical chemistry, so I have a limited knowledge on pharmacokinetics. I purchased this textbook because I have the options to take an online 15 weeks class along this book with University of Georgia and to take an online test from ASHP after completion of this book. I did the latter. The book is actually short. Although the book is designed to be a textbook for a 15-weeks online course, I was able to read through it within 3 weeks, passed the ASHP test while holding a full time job. I admit that I often spent 2 hour a day reading the book and many people may not able to afford. That being said, I am certain that most people can finish this book within 15 weeks at a very relax pace. I find the book very easy to understand and enjoyable to read. The math requirement for this book is on the algebra level, although a basic calculus level is needed to fully appreciate the theories and the math. The book has some typos, especially during the “Exercises and Problems” sections. In addition, it is more expensive than other pharmacokinetics books on the market.
I highly recommend this book for anyone who is new to pharmacokinetics and want a short, enjoyable introductory book.
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Posted: November 20th, 2008, 1:39pm CET by addebook
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
by B.E. Maryanoff, A.B. Reitz
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
By B.E. Maryanoff, A.B. Reitz
Publisher: Elsevier Science
Number Of Pages: 336
Publication Date: 1999-04-01
ISBN-10 / ASIN: 0762300647
ISBN-13 / EAN: 9780762300648
Binding: Hardcover
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
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Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices
by Kim Huynh-Ba
Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices
By Kim Huynh-Ba
Publisher: Springer
Number Of Pages: 328
Publication Date: 2008-11-25
ISBN-10 / ASIN: 0387856269
ISBN-13 / EAN: 9780387856261
Binding: Hardcover
A COMPREHENSIVE AND PRACTICAL GUIDE TO STABILITY TESTING IN PHARMACEUTICAL DEVELOPMENT
Stability testing is required to demonstrate that a pharmaceutical product meets its acceptance criteria throughout its shelf life and to gain regulatory approval for commercialization. Assessing drug product stability and safety can be quite complicated, and stability profile can impact many functional areas, including analytical testing, formulation development, toxicology, quality, and regulatory affairs.
Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices is the first volume to cover all aspects of stability testing in pharmaceutical development. It presents a scientific understanding of regulations and balances methodologies and best practices. Comprising 17 chapters, it provides a wealth of resources for pharmaceutical companies, educational institutions, and manufacturing laboratories to use as either a supplementary text for stability training courses or as a reference book for pharmaceutical practitioners.
Topics covered include:
Latest regulations for stability testing, including cGMP requirements, ICH guidelines, and global guidances from WHO, ASEAN, EMRO, and other regions.
Post-approval considerations and regulatory filing strategies to support a global supply chain.
Methodologies, including development of a stability-indicating method, method validation, and transfer. This book also discusses physical stability, non-chromatographic methodologies, and spectroscopic applications.
Setting specifications, monitoring impurities, and establishing shelf-life of pharmaceutical products.
Data management, including stability reports, CMC, and discussion of out-of-specification (OOS) and out-of-trend (OOT).
USP-NF testing in support of stability.
Current industry best practices on stability operation, validation, and calibration of stability chambers including considerations for photo-stability testing.
Discussion of matrixing and bracketing to support reduced stability testing.
Overview of stability programs for biologics and drug-in-devices pharmaceutical products.
This collective work was written by a group of prominent international experts, who have been directly responsible for instituting industry best practices and establishing the current stability guidelines.
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In Vitro Methods in Pharmaceutical Research
by Jose V. Castell, Maria Jose Gmez-Lechn
In Vitro Methods in Pharmaceutical Research
By Jose V. Castell, Maria Jose Gmez-Lechn
Publisher: Academic Press
Number Of Pages: 467
Publication Date: 1997-01-15
ISBN-10 / ASIN: 012163390X
ISBN-13 / EAN: 9780121633905
Binding: Hardcover
In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies.
Key Features
* Meets the continuing demand for information in this field
* Compares In Vitro techniques with other methods
* Describes cell-culture methods used to investigate toxicity in cells derived from different organs
* Includes contributions by leading experts in the field
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Cyclic Gmp: Synthesis, Metabolism, and Function (Advances in Pharmacology)
by Ferid Murad, J. Thomas August, M. W. Anders
Cyclic Gmp: Synthesis, Metabolism, and Function (Advances in Pharmacology)
By Ferid Murad, J. Thomas August, M. W. Anders
Publisher: Academic Press
Number Of Pages: 335
Publication Date: 1994-01-15
ISBN-10 / ASIN: 0120329263
ISBN-13 / EAN: 9780120329267
Binding: Hardcover
This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.
Key Features
* Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis
* Cyclic GMP-dependent protein kinase
* Hormones and ligands that regulate GMP formation and/or metabolism
* Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport
* Clinical studies with cyclic GMP and atrial natriuretic peptide
* Important questions and experiments for the future
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Advances in Clinical Chemistry: v. 7
by H Sobotka
Advances in Clinical Chemistry: v. 7
By H Sobotka
Publisher: Academic Press Inc.,U.S.
Number Of Pages:
Publication Date:
ISBN-10 / ASIN: 0120103079
ISBN-13 / EAN: 9780120103072
Binding: Hardcover
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Advances in Clinical Chemistry: v. 13
by
Advances in Clinical Chemistry: v. 13
Publisher: Academic Press Inc.,U.S.
Number Of Pages: 533
Publication Date: 1971-01
ISBN-10 / ASIN: 0120103133
ISBN-13 / EAN: 9780120103133
Binding: Hardcover
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Advances in Clinical Chemistry: v. 8
by H Sobotka
Advances in Clinical Chemistry: v. 8
By H Sobotka
Publisher: Academic Press Inc.,U.S.
Number Of Pages:
Publication Date:
ISBN-10 / ASIN: 0120103087
ISBN-13 / EAN: 9780120103089
Binding: Hardcover
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Posted: November 20th, 2008, 6:53am CET by addebook
Advances in Clinical Chemistry: v. 6
by H Sobotka
Advances in Clinical Chemistry: v. 6
By H Sobotka
Publisher: Academic Press Inc.,U.S.
Number Of Pages:
Publication Date:
ISBN-10 / ASIN: 0120103060
ISBN-13 / EAN: 9780120103065
Binding: Hardcover
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Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
by B.E. Maryanoff, A.B. Reitz
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
By B.E. Maryanoff, A.B. Reitz
Publisher: Elsevier Science
Number Of Pages: 336
Publication Date: 1999-04-01
ISBN-10 / ASIN: 0762300647
ISBN-13 / EAN: 9780762300648
Binding: Hardcover
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
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The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders
by Divya Vohora
The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders
By Divya Vohora
Publisher: CRC
Number Of Pages: 400
Publication Date: 2008-11-13
ISBN-10 / ASIN: 1420053922
ISBN-13 / EAN: 9781420053920
Binding: Hardcover
Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resourcepresents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studies indicating earliest possible stages of development.The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, selective ligands, and therapeutic potential. Several chapters address disorders involving H3, including Alzheimer’s, ADHD, sleep disorders, epilepsy, obesity, and psychiatric and neurodegenerative disorders.
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Bioinformatics in Cancer and Cancer Therapy (Cancer Drug Discovery and Development)
by Gavin J. Gordon
Bioinformatics in Cancer and Cancer Therapy (Cancer Drug Discovery and Development)
By Gavin J. Gordon
Publisher: Humana Press
Number Of Pages: 202
Publication Date: 2008-11-21
ISBN-10 / ASIN: 1588297535
ISBN-13 / EAN: 9781588297532
Binding: Hardcover
Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Although no single person or group started the field wholly on their own, Temple Smith, Ph.D., a professor at Boston University, is generally credited with coining the term. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics, fields of study that have historically existed as mutually exclusive disciplines.
Concurrently, bioinformatics has vaulted into the public’s eye in lay newspapers and magazines, most notably in the area of (personalized) DNA sequencing. The combined result is that bioinformatics is being heralded as a panacea to the current limitations in the clinical management of cancer. While certainly over optimistic in some regards, this designation is not without promise particularly in the area of cancer diagnosis and prognosis.
The focus of this book is to: i) to provide a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments, ii) to show how a bioinformatics approach has been used to characterize various cancer-related processes, and iii) to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.
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Nuclear Receptors in Drug Metabolism
Nuclear Receptors in Drug Metabolism
By Wen Xie
Publisher: Wiley
Number Of Pages: 330
Publication Date: 2008-11-03
ISBN-10 / ASIN: 0470086793
ISBN-13 / EAN: 9780470086797
Binding: Hardcover
Providing an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development, this book equips drug development scientists with an interdisciplinary understanding of these receptors and how to regulate them. This aids in pharmaceutical research to target drugs and treat diseases like cancer, coronary heart disease, and diabetes. A single source for researchers, this book collects material otherwise scattered among journals, and adds background and applications data to make the chapters more comprehensive.
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Drug Facts and Comparisons: Pocket Version 2009 (Drug Facts and Comparisons (Pocket ed))
Drug Facts and Comparisons: Pocket Version 2009 (Drug Facts and Comparisons (Pocket ed))
By Facts & Comparisons
Publisher: Lippincott Williams & Wilkins
Number Of Pages: 1344
Publication Date: 2008-05-01
ISBN-10 / ASIN: 1574392921
ISBN-13 / EAN: 9781574392920
Binding: Paperback
Drug Facts and Comparisons: Pocket Version 2009 is the ideal resource for the drug information you need at the point of care. Abridged from Drug Facts and Comparisons, this handy pocket version allows you to confirm critical drug information immediately in a quick-reference format. Pocket Drug Facts and Comparisons features the most commonly used drugs, conveniently addressing topics that demand attention. Features include: Rx and OTC drugs; similar products listed together in tables for easy comparison; more than 2,000 brand name and 600 generic drugs; dozens of convenient charts and tables; and more than 400 monographs.
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Pharmacogenomics and Personalized Medicine (Methods in Pharmacology and Toxicology) (Methods in Pharmacology and Toxicology)
by Nadine Cohen
Pharmacogenomics and Personalized Medicine (Methods in Pharmacology and Toxicology) (Methods in Pharmacology and Toxicology)
By Nadine Cohen
Publisher: Humana Press
Number Of Pages: 528
Publication Date: 2008-09-25
ISBN-10 / ASIN: 1934115045
ISBN-13 / EAN: 9781934115046
Binding: Hardcover
With all the multitude of challenges facing the pharmaceutical research and development process, the industry is actively exploring the relationships between human genetics and drug responsiveness, susceptibility to disease and disease severity. In Pharmacogenomics and Personalized Medicine, leading experts from the pharmaceutical industry, the scientific community and the government provide guidance for conducting pharmacogenomic research from discovery to the market, while also presenting a realistic perspective on the challenges, practicalities and obstacles in its application. Focusing on DNA data and associated analytical methodologies, with a consideration for complementary RNA-based studies, this volume includes a wide array of vital, cutting-edge research.
Comprehensive and timely, Pharmacogenomics and Personalized Medicine will assist novice and experienced investigators alike in the understanding of the current scientific challenges in applying pharmacogenomics to drug discovery and clinical development.
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Quality Systems and Controls for Pharmaceuticals
Quality Systems and Controls for Pharmaceuticals
By Dipak Kumar Sarker
Publisher: Wiley
Number Of Pages: 204
Publication Date: 2008-10-20
ISBN-10 / ASIN: 0470056924
ISBN-13 / EAN: 9780470056929
Binding: Hardcover
Quality Systems and Control for Pharmaceuticals is an accessible overview of the highly-regulated area of pharmaceutical manufacture, the production of biomedical materials, and biomedical devices. Introducing the subject in a clear and logical manner it enables the reader to grasp the key concepts of the multidisciplinary area of control science and specifically quality control using industrial and theoretical models.
Taking a multidisciplinary approach to the subject the reader is guided through key topics such as product safety which takes into account aspects of analytical science, statistics, microbiology, biotechnology, engineering, business practice and optimizing models, the law and safeguarding public health, innovation and inventiveness and contemporary best practice.
The author has both industry and academic experience and many ‘best practice’ examples are included throughout the text based on his own industry experience and current practicing industrial pharmacists. This is an invaluable reference for all students of pharmacy who may have little or no familiarity with industrial practice and for those studying BSc chemistry, biomedical sciences, process analytical chemistry and MSc in Industrial Practice.
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Posted: November 9th, 2008, 3:13pm CET by addebook
ATLAS FARMACOPEA “A coloured Atlas of the chinese Materia Medica [English-chinese Latin]
by Pharmacopea Commission of the Ministry of Public Health China
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Posted: November 9th, 2008, 3:12pm CET by addebook
Taoism (Religions of the World)
Taoism (Religions of the World)
By Hsiao-Lan Hu, William Cully Allen
Publisher: Chelsea House Publications
Number Of Pages: 108
Publication Date: 2005-02-28
ISBN-10 / ASIN: 0791080994
ISBN-13 / EAN: 9780791080993
Binding: Library Binding
A Chinese mystical philosophy, Taoism was founded by Lao-tzu in the sixth century B.C. Taoism is a way of life promoting the “Tao” as a force that flows through all sentient beings. When the Tao is in balance, perfect happiness is possible.
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Posted: November 8th, 2008, 5:11am CET by addebook
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization
by Edward Kerns, Li Di
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization
By Edward Kerns, Li Di
Publisher: Academic Press
Number Of Pages: 552
Publication Date: 2008-02-01
ISBN-10 / ASIN: 0123695201
ISBN-13 / EAN: 9780123695208
Binding: Hardcover
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process.
The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.
* Serves as an essential working handbook aimed at scientists and students in medicinal chemistry
* Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies
* Discusses improvements in pharmacokinetics from a practical chemist’s standpoint
Summary: A very impressive book!
Rating: 5
I have spent some of the last two days reading this book and I am very impressed with it. It is destined to become an authoritative text on the whole topic area of drug-like molecules and ADME screening. The chapters are well written and include sufficient detail and references so that the reader can make use of the information effectively. The book could be used in a graduate-level course for medicinal chemists or DMPK scientists.
The book would also be very helpful for scientists working in one area of DMPK who wish to become DMPK project managers and need to increase their understanding of other areas of DMPK that are outside of their own specific expetise function. The chapter on pharmacokinetics was well written and provides a very good overview of the topic. Overall, I can state that this book is well worth the purchase price.
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Posted: November 8th, 2008, 5:10am CET by addebook
Chemogenomics: Knowledge-based Approaches to Drug Discovery
Chemogenomics: Knowledge-based Approaches to Drug Discovery
By Edgar Jacoby
Publisher: Imperial College Press
Number Of Pages: 220
Publication Date: 2006-05-11
ISBN-10 / ASIN: 1860946135
ISBN-13 / EAN: 9781860946134
Binding: Hardcover
In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, “Chemogenomics” aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays. This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided.
Contents:
* Small Molecules for Chemogenomics-based Drug Discovery (E Jacoby et al.)
* Mapping the Chemogenomic Space (J Mestres)
* Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development (F J Dekker et al.)
* A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries (R Crossley & M Slater)
* In silico Screening of the Protein Structure Repertoire and of Protein Families (D Rognan)
* New Methods for Smilarity-based Virtual Screening (J Hert et al.)
* Structural Informatics: Chemogenomics In silico (D A Debe et al.)
* Construction of a Homogenous and Informative In vitro Profiling Database for Anticipating the Clinical Effects of Drugs (N Froloff et al.)
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Posted: November 8th, 2008, 5:09am CET by addebook
Assorted Nasties
by David Harber
Assorted Nasties
By David Harber
Publisher: Desert Pubns
Number Of Pages: 138
Publication Date: 1993-07
ISBN-10 / ASIN: 0879472316
ISBN-13 / EAN: 9780879472313
Binding: Paperback
Summary: Don’t try this at home
Rating: 4
For educational purpose only ,this book is a goldmine for anyone interested
in poisons their chemistry and effects.
Summary: Not a bad book
Rating: 5
This is a damn good book it covers all kinds of Toxins and a few
Delivery Systems that will blow your mind they are so simple to make and work….
Summary: IF YOU CAN FIND THIS BOOK, IT’S HANDY!
Rating: 5
Writers will find ASSORTED NASTIES a very useful guide to poisons and other chemical means of killing off a character. Based on the legendary Devil’s Diary, a supposed chemical and biological agent manual produced by the CIA in the 1950s, this little manual is packed full of toxins and delivery systems from nicotine (yes, it’s a poison!) to a pocket crossbow.
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Posted: November 5th, 2008, 1:18pm CET by addebook
Dermal Absorption and Toxicity Assessment, Second Edition (Drugs and the Pharmaceutical Sciences)
Dermal Absorption and Toxicity Assessment, Second Edition (Drugs and the Pharmaceutical Sciences)
By Michael S. Roberts, Kenneth A. Walters
Publisher: Informa HealthCare
Number Of Pages: 600
Publication Date: 2007-12-14
ISBN-10 / ASIN: 0849375916
ISBN-13 / EAN: 9780849375910
Binding: Hardcover
The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies
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Posted: November 4th, 2008, 8:29am CET by addebook
Trends in Drug Research II (Pharmacochemistry Library)
Trends in Drug Research II (Pharmacochemistry Library)
By H. van der Goot
Publisher: Elsevier Science
Number Of Pages: 258
Publication Date: 1998-01-01
ISBN-10 / ASIN: 0444826335
ISBN-13 / EAN: 9780444826336
Binding: Hardcover
This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium Trends in Drug Research, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997.
In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology.
Other topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?)
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Posted: November 4th, 2008, 8:28am CET by addebook
Herbal Pharmacology in the People’s Republic of China: A Trip Report of the American Herbal Pharmacology Delegation
by The Committee on Scholarly Communication with the People’s Republic of China
Herbal Pharmacology in the People’s Republic of China: A Trip Report of the American Herbal Pharmacology Delegation
By Herbal Pharmacology Study Group of The Committee on Scholarly Communication with the People’s Republic of China
Publisher: National Academy of Sciences (USA)
Number Of Pages: 269
Publication Date: 1975
ISBN-10 / ASIN: 0309024382
ISBN-13 / EAN: 9780309024389
Binding: Unknown Binding
The Committee on Scholarly Communication with the People’s Republic of China
sponsored the visit of a twelve-member Herbal Pharmacology Study Group to the
People’s Republic of China from June 1 to June 26, 1974. In China, the group
was hosted by the Chinese Medical Association. This report is a compilation of
the findings of the group members, whose task was to discuss research on natural
products for therapeutic use, identification of medically effective elements, and
development of synthetic drugs with those elements. The group visited Peking,
Tientsin, Shanghai, Nanking, Hangchow, and Kwangchow.
Review:
“During the month of June 1974, twelve U.S. specialists in chemistry, medicine, pharmacology, pharmacognosy, pharmacy, and Chinese culture visited a series of major Chinese cities for the purpose of assessing the current status of herbal pharmacology (both basic and clinical) in the People’s Republic of China.” So begins this late Nixon-era publication from the National Academy of Sciences. The Red Guards were muttering off in the provinces, China was now “in”, acupuncture was being “studied” in the US and many things Chinese were now politically correct. This delegation was sent to the PRC to check out the uses of herbs within Chinese medicine, struggling to its feet after nearly a decade of intellectual and political nihilism, and it offers insights into that time and into how western pharmaceutical folks viewed Chinese herbs. It examined in detail the verifiable effects of over 250 chinese herbs, while missing totally the energetics of therapy. I ate the book up when it first came out, and, with so many more “correct” works since published, the TCM community seems to have forgotten this arcane but sensible first peek into Chinese Herbal Medicine
KEYWORDS: Ethnobotany, Traditional Chinese Medicine, Herbal Medicine
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Posted: November 4th, 2008, 8:27am CET by addebook
Antibiotic Policies: Fighting Resistance
Antibiotic Policies: Fighting Resistance
By Ian M. Gould, Jos W.M. van der Meer
Publisher: Springer
Number Of Pages: 286
Publication Date: 2007-09-12
ISBN-10 / ASIN: 0387708405
ISBN-13 / EAN: 9780387708409
Binding: Hardcover
Antibiotic resistance has reached epidemic proportions in most hospitals and many communities around the world. While control methods have traditionally (and usually unsuccessfully) relied on preventing cross infection it is increasingly obvious that new solutions are needed. There is growing evidence that the solution will lie in more careful use of antibiotics in the future. The golden age of antibiotic therapy has gone, probably for good and prescribers (and society at large) will have to accept that, in future, antibiotics will not be the “cure all” we have been accustomed to. This book addresses many of the key issues taxing our society and hospitals in an era of epidemic resistance and shortage of new antibiotics. Written by internationally renowned experts in the field, this volume will provide practical advice and inform control strategies for the most urgent of problems related to antibiotic resistance epidemic for years to come. Antibiotic Policies: Fighting Resistance is an ideal volume for health professionals with an interest in this field.
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Posted: November 3rd, 2008, 11:52am CET by addebook
Ginseng (Keats Good Herb Guides)
Ginseng (Keats Good Herb Guides)
By Kathi Keville
Publisher: Keats Pub
Number Of Pages: 90
Publication Date: 1996-10
ISBN-10 / ASIN: 0879837314
ISBN-13 / EAN: 9780879837310
Binding: Paperback
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Posted: November 3rd, 2008, 11:51am CET by addebook
Pharma-Ecology: The Occurrence and Fate of Pharmaceuticals and Personal Care Products in the Environment
Pharma-Ecology: The Occurrence and Fate of Pharmaceuticals and Personal Care Products in the Environment
By Patrick K. Jjemba
Publisher: Wiley
Number Of Pages: 314
Publication Date: 2008-08-25
ISBN-10 / ASIN: 0470046309
ISBN-13 / EAN: 9780470046302
Binding: Hardcover
Pharmaceuticals and personal care products—we can’t live without them. Can the environment survive with them?
Pharmaceutical and personal care products (PPCPs) are increasingly being recognized as micropollutants. In this context, pharmaceutical products encompass a diverse range of drugs used to treat various illnesses, and personal care products include everyday items such as soaps, fragrances, cleaning agents, disinfectants, and similar products. Written for professionals from different backgrounds, Pharma-Ecology bridges the knowledge and language gap and critically examines the issue of PPCP micropollutants and how to best minimize their impact on the environment. Organized systematically, it:
Presents a range of pharmaceutical compounds categorized by mode of action and common usage, displaying the volumes (or number of prescriptions) that are dispersed
Discusses the detection of PPCPs in the environment using instrumentation and bioassay techniques, including microarrays
Covers the occurrences of PPCPs in aquatic systems, sediments, soil, and aerial environments
Considers the persistence and degradation of PPCPs in the environment, and links pharmacokinetics/pharmacodynamics with the kinetics of PPCPs in the environment
Explores engineering and treatment techniques that could minimize the impact of PPCPs in the environment
Includes numerous tables and figures that illustrate information
This is an enlightening reference for engineers, toxicologists, ecologists, micro-biologists, and chemists involved in pollution and environmental analysis; policy-makers; professionals in federal and state regulatory agencies; and pharmaceutical professionals. It is also an excellent text for undergraduate and graduate students in related fields.
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Posted: November 3rd, 2008, 11:50am CET by addebook
Quanta, Logic and Spacetime, Second Edition
Quanta, Logic and Spacetime
By S. A. Selesnick
Publisher: World Scientific Publishing Company
Number Of Pages: 488
Publication Date: 2003-12
ISBN-10 / ASIN: 9812386912
ISBN-13 / EAN: 9789812386915
Binding: Hardcover
In this expanded edition of Quanta, Logic and Spacetime, the logical base is greatly broadened and quantum-computational aspects of the approach are brought to the fore. The first two parts of this edition may indeed be regarded as providing a self-contained and logic-based foundation for — and an introduction to — the enterprise known as quantum computing.
The rest of the work takes on the task (as in the first edition) of computing from first principles certain dynamical expressions which turn out to compare favorably with the Lagrangian densities of the (massless) Standard Model, including gravity. The logic of this process is now subject to greater formal rigor than was possible in the first edition, and the central thesis — that quantum physics at a fundamental level may itself be realized as a species of quantum computation — is strongly underscored.
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Posted: November 3rd, 2008, 11:49am CET by addebook
Polymers in Drug Delivery
by Ijeoma F. Uchegbu, Andreas G. Schatzlein (Editors)
Polymers in Drug Delivery
By Ijeoma F. Uchegbu, Andreas G. Schatzlein
Publisher: CRC
Number Of Pages: 280
Publication Date: 2006-05-19
ISBN-10 / ASIN: 0849325331
ISBN-13 / EAN: 9780849325335
Binding: Hardcover
In recent years there has been an explosion in the use of polymers to solve various biomedical problems. Polymers play a crucial role in controlling drug release rate, enhancing drug solubility and uptake, and limiting drug degradation and toxicity. Polymers in Drug Delivery is a state-of-the-art documentation and review of all areas in which polymers are used in drug delivery, including hydrogels, soluble polymer drug conjugates, polymeric vesicles and micelles, microspheres, nanoparticles, polymeric in tissue engineering, and more. It is a readily accessible volume suitable for drug delivery scientists and as reading for advanced pharmaceutics students and others new to the field.
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Posted: November 2nd, 2008, 1:54am CET by addebook
Statistical and Computational Pharmacogenomics (Interdisciplinary Statistics)
Statistical and Computational Pharmacogenomics (Interdisciplinary Statistics)
By Rongling Wu, Min Lin
Publisher: Chapman & Hall/CRC
Number Of Pages: 368
Publication Date: 2008-08-08
ISBN-10 / ASIN: 1584888288
ISBN-13 / EAN: 9781584888284
Binding: Hardcover
Synthesizes the Vast Literature on One of the Hottest Areas in Biomedical Research
Building a bridge between pharmacogenomics and statistics, Statistical and Computational Pharmacogenomics allows researchers to readily familiarize themselves with this promising and revolutionary area of science. It outlines the powerful statistical techniques used in the fast-growing field of pharmacogenomics, which seeks to understand the relationships between interpatient variability in drug response and specific genomic sites. Providing geneticists with the tools needed to understand and model the genetic variations for drug responses, this seminal work also equips statisticians with the motivation and ideas needed to explore genomic data.
Exciting Implications for the Future of Drug Therapies
In addition to providing a synthesis of statistical methodology for the pharmocogenomic study of drug response, this cutting-edge, authoritative text developseach method step-by-step, while keeping theoretical details to a minimum. It also presents detailed, worked examples that outline how to apply the discussed methods and outlines the necessary statistical and computational theories for genetic mapping of dynamic traits.
Indicative of the depth of this groundbreaking, multidisciplinary research and its exciting implications for the future of drug therapies, it is now possible to document, map, and understand the structure and patterns of the human genome linked to drug response. The pioneering process of functional mapping has the potential to revolutionize the use of many medications with tailored treatment plans based on patients’ individual genetic makeup. This will ideally lead to optimal prescriptions, optimal administration times, and optimal dosage scheduling.
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Posted: November 2nd, 2008, 1:53am CET by addebook
Design of Caspase Inhibitors as Potential Clinical Agents (Enzyme Inhibitors)
Design of Caspase Inhibitors as Potential Clinical Agents (Enzyme Inhibitors)
By Tom O’Brien, Steven D. Linton
Publisher: CRC
Number Of Pages: 327
Publication Date: 2008-10-27
ISBN-10 / ASIN: 1420045407
ISBN-13 / EAN: 9781420045406
Binding: Hardcover
Caspases represent one of the most specific protease families described to date. As caspase family members are involved in pro-inflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agents discusses the role of cysteine aspartyl proteases (caspases) in inducing cell death. It reviews recent efforts to develop small molecular inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecular inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.
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Posted: November 2nd, 2008, 1:52am CET by addebook
Duke’s Handbook of Medicinal Plants of Latin America
Duke’s Handbook of Medicinal Plants of Latin America
By James A. Duke
Publisher: CRC
Number Of Pages: 832
Publication Date: 2008-10-24
ISBN-10 / ASIN: 1420043161
ISBN-13 / EAN: 9781420043167
Binding: Hardcover
A Comprehensive Guide Addressing Safety, Efficacy, and Suitability
About a quarter of all the medicines we use come from rainforest plants and more than 1,400 varieties of tropical plants are being investigated as potential cures for cancer. Curare comes from a tropical vine and quinine from the cinchona tree. A comprehensive guide to safety, efficacy, and suitability, Duke’s Handbook of Medicinal Plants of Latin America responds to continuing interest in medicinal plants and the potential remedies they contain.
Determine Which Species Can Be Used for Specific Targets
The author of Green Pharmacy Herbal Handbook and CRC Handbook of Medicinal Herbs, James A. Duke covers roughly 500 of the more important Native Latin American medicinal plants in a highly organized format. After a brief introduction, each entry contains scientific and colloquial names, synonyms, reference to illustrations, notes, biological activities, medicinal indications, dosages, potential hazards, extracts, and references. This format supplies a starting point for determining which species can be used for specific targets.
Better Data Helps You Focus Your Search
Year-round moderate temperatures, abundant rainfall, and rich soils make tropical Latin America home to nearly 100,000 of the world’s 300,000 known species of plants, and therefore home to untold numbers of potential cures. Focusing on 500 of the most well-known and well-studied plants, this book helps you focus your search for ammunition against constantly evolving pathogens and newly emerging diseases.
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Herbs for the Heart: Herbs to Lower Cholesterol and Blood Pressure, Increase Circulation, Prevent Clotting, and Enhance Heart Heath (Keats Good Herb Guide Series)
by C. J. Puotinen
Herbs for the Heart: Herbs to Lower Cholesterol and Blood Pressure, Increase Circulation, Prevent Clotting, and Enhance Heart Heath (Keats Good Herb Guide Series)
By C. J. Puotinen
Publisher: Keats Pub
Number Of Pages: 90
Publication Date: 1997-05
ISBN-10 / ASIN: 0879837969
ISBN-13 / EAN: 9780879837969
Binding: Paperback
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