Technological Innovation Comparing Development of Drugs, Devices, and Procedures in Medicine
by: by Annetine C. Gelijns.
en | National Academy Press

9780309577472

Contents
Preface
1. Introduction: An Initial Conceptualization of the Development Process 1
2. The Development of Drugs 8
3. The Development of Medical Devices 23
4. The Development of Clinical Procedures 34
5. Improving the Translation of Research Findings into Clinical Practice: Some Opportunities for Change 40
Appendix 53
References 55
CONTENTS v
About this

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British Pharmacopoeia 2009
by: British Pharmacopoeia Commission

British Pharmacopoeia 2009
By British Pharmacopoeia Commission

Publisher: Stationery Office (U.K.)
Number Of Pages: 3500
Publication Date: 2008-08-15
ISBN-10 / ASIN: 011322799X
ISBN-13 / EAN: 9780113227990

Product Description:

"The British Pharmacopoeia" ("BP") 2009 is the authoritative, current collection of standards for UK medicinal substances and the official source of all UK pharmaceutical quality standards. It is an essential reference for anyone involved in pharmaceutical research, development, manufacture and testing, and plays a vital role in ensuring that all medicinal substances on the UK market meet standards of safety, quality and efficacy.The "BP" comprises monographs, which set out the mandatory standards for active substances, excipients and formulated preparations, together with supporting General Notices, Appendices (test methods, reagents, etc) and Reference Spectra. Detailed information and guidance on various aspects of current pharmacopoeial policy and practice are provided in the Supplementary Chapters of the "BP".The "BP" is supplied in a variety of formats designed for ease of use and a wide range of applications. The hard copy edition comprises a five-volume boxed set containing the "BP" in four volumes and the "BP" (Veterinary) volume, plus single user access to the "BP" Online, the dedicated BP website. The online format is easy to network, allowing access for a specified number of users or across an entire organisation site.Following registration - using the ID code supplied with the hard copy - customers will be granted a single user licence to access BP on-line and will have the option to receive the CD-ROM, which contains the whole of the current "British Pharmacopoeia".It is effective as of 1 January 2009. It includes: a significant number of new UK monographs; all "European Pharmacopoeia 6th Edition" material up to and including "Supplement 6.2" integrated into the text of "BP 2009"; new and revised monographs for Complementary, Herbal and Homoeopathic medicines with their own section in Volume III; and networking with full technical support from TSO, the publisher of the "BP". The on-line version delivers the complete text of the "British Pharmacopoeia and European Pharmacopoeia" standards to your PC. The new features include an alphabetical index, user-friendly search interface design, and a facility to create a ‘My BP’ section." British Pharmacopoeia 2009" eBook - "The complete British Pharmacopoeia 2009" is now available exclusively to "BP 2009" purchasers in an innovative new format. The eBook is greatly suited to this large reference text making the information contained within it available to all of those who wish to access it on the move and away from their desks.British Pharmacopoeia 2009 Concurrent Licence (Online) - "The British Pharmacopoeia" is available as a network licence which can be used on a concurrent user basis. It allows a designated number of staff simultaneous access to the online version of the "British Pharmacopoeia 2009". Once set up, your workforce can then start using the BP at their convenience.

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The Engines of Hippocrates: From the Dawn of Medicine to Medical and Pharmaceutical Informatics (Wiley Series on Technologies for the Pharmaceutical Industry)
by: Barry Robson, O. K. Baek

The Engines of Hippocrates: From the Dawn of Medicine to Medical and Pharmaceutical Informatics (Wiley Series on Technologies for the Pharmaceutical Industry)
By Barry Robson, O. K. Baek

Publisher: Wiley
Number Of Pages: 616
Publication Date: 2009-06-22
ISBN-10 / ASIN: 0470289538
ISBN-13 / EAN: 9780470289532

Product Description:

A unique, integrative look at information-based medicine

The convergence of medical science, biology, pharmacology, biomedical engineering, healthcare, and information technology is revolutionizing medical and scientific practice, and has broader social implications still being understood. The Engines of Hippocrates provides a unique, integrative, and holistic look at the new paradigm of information-based medicine, covering a broad range of topics for a wide readership.

The authors take a comprehensive approach, examining the prehistory, history, and future of medicine and medical technology and its relation to information; how history led to such present-day discoveries as the structure of DNA, the human genome, and the discipline of bioinformatics; and what the future results of these discoveries may hold. Their far-ranging views are their own and not necessarily those of the IBM Corporation or other employers.

The Engines of Hippocrates helps readers understand:

Forces shaping the pharmaceutical and biomedical industries today, including personalized medicine, genomics, data mining, and bionanotechnology
The relationship between pharmaceutical science today and other disciplines such as philosophy of health, history, economics, mathematics, and computer science

The integrated role alternative and non-Western medicines could play in a new, information-based medicine

Practical, ethical, organizational, technological, and social problems of information-based medicine, along with a novel data-centric computing model and a self-adaptive software engineering model, and corresponding information technology architectures, including perspectives on sharing remote data efficiently and securely for the common good

An unmatched, cross-disciplinary perspective on the big picture of today and tomorrow’s medicine, The Engines of Hippocrates provides a reference to interested readers both inside and outside the pharmaceutical and medical communities, as well as a peerless classroom supplement to students in a wide variety of disciplines.

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Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development
by: H. John Smith, Claire Simons
en | CRC

0415273498 0203219171 9780415273497 9780203694855 9780203219171

Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development
By H. John Smith, Claire Simons

Publisher: CRC
Number Of Pages: 440
Publication Date: 2002-03-28
ISBN-10 / ASIN: 0415273498
ISBN-13 / EAN: 9780415273497

Product Description:

Proteinase and Peptidase Inhibition presents a series of up-to-date progress reports on the characterization of a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs. The classification of target enzymes by structural similarity, rather than by pharmacological effects, provides a new and coherent platform for understanding how inhibition of different targets can lead to the same therapeutic outcomes.

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The 2002 World Market Forecasts for Imported Medicaments including Veterinary Medicaments
by: Philip M. Parker

This series was created for international firms who rely on foreign export markets for a
substantial portion of their business or who might be threatened by foreign trade competition.
The estimates given in this report were created using a methodology developed by and under the
direct supervision of Professor Philip M. Parker, the Eli Lilly Chaired Professor of Innovation,
Business and Society, at INSEAD. The methodology, relying on historical figures of economic
growth and trade flows, estimates the market shares of some 150 countries for over 500 industrial
or product categories. The figures should be seen as market estimates, as opposed to historical
records, as these are projected for the current year of trade.

Publisher: Icon Group International, Incorporated
Publication Date: 2002-01-01
ISBN-10 / ASIN: 0597983526
ISBN-13 / EAN: 9780597983528

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Plant Drug Analysis: A Thin Layer Chromatography Atlas
by: Hildebert Wagner, Sabine Bladt

Plant Drug Analysis: A Thin Layer Chromatography Atlas
By Hildebert Wagner, Sabine Bladt

Publisher: Springer
Number Of Pages: 384
Publication Date: 2003-02-28
ISBN-10 / ASIN: 3540586768
ISBN-13 / EAN: 9783540586760

Product Description:

This second edition of Plant Drug Analysis includes more than 200 updated color photographs of superb quality demonstrating chromatograms of all relevant standard drugs. The atlas will be a useful reference for analyzing plant drugs, identifying unknown drugs or monitoring the purity or constituents of a given drug. All drugs presented meet the standard of the official pharmacopoeia and originate from well-defined botanical sources. With this guide the technique of thin layer chromatography can be easily used without previous pharmacognostic training. Only commercially available equipment and reagents are needed, the sources as well as all practical details are given.

Summary: Useful
Rating: 4

I found this book very useful for the professionals involved in the extraction of raw materials from natural sources. Since you have the opportunity to browse the index, you can check first if the book contains information about the specific compound or subject that you are looking for. The book is very well illustrated.

Summary: Plant Drug Analysis
Rating: 5

About this atlas

This second edition of Plant Drug Analysis includes more than 200 updated color photographs of superb quality demonstrating chromatograms of all relevant standard drugs. The atlas will be a useful reference for analyzing plant drugs, identifying unknown drugs or monitoring the purity or constituents of a given drug. All drugs presented meet the standard of the official pharmacopoeia and originate from well-defined botanical sources. With this guide the technique of thin layer chromatography can be easily used without previous pharmacognostic training. Only commercially available equipment and reagents are needed, the sources as well as all practical details are given.

Written for:

Researchers, Analytical Pharmacists, Pharmaceutical Companies

Keywords:

Alkaloide

Alkaloids

Balsams

Coumarin

Drogenanalyse

Drug

Ginkgo bilboba

Ginkgo biloba

Glycoside drugs

Pflanzeninhaltsstoffe

Terpene

Terpenes

Summary: Comments on H Wagner’s book "Plant Drug Analysis:……….
Rating: 5

I used to have a copy of the book until I lended to someone. It was an excelent refference for quality control of medicinal plants an for preparing monographs. The presentation of the coloured T.L.C. traces is impressing, the information can be trusted and it is clearly and concisely presented.

Summary: help need
Rating: 3

I want to check a method in that book. That method is very helpful to do my experiment.In our library, this book was borrowed our. But I want to know this method in a hurry. So I am eager to read this book.

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A guide for pharmacists (丿賱賷賱 廿乇卮丕丿賷 賱賱氐賷丕丿賱丞)
by:

this is a research (graduation project)
is made by students form the university of Damascus - faculty of pharmacy
under supervision prof dr Mohammad amer mardini
thusis work done by - Mary kudsi - mayes rahmoun - valentina bitar - okba rahhal
and with pharmacist iyas aldib

it is a guide for pharmacists for daily practice in Arabic language

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Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition
by: H. John Smith

Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition
By H. John Smith

Publisher: CRC
Number Of Pages: 720
Publication Date: 2004-07-15
ISBN-10 / ASIN: 0415288770
ISBN-13 / EAN: 9780415288774

Product Description:

As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states.Smith and Williams’ Introduction to the Principles of Drug Design and Action, 4th Edition provides a thorough introduction to the principles of rational drug design, including both novel and established approaches. The fourth edition of this popular textbook adopts a ‘from the bench to the marketplace’ approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added

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Vitamins and Hormones: Advances in Research and Applications: v. 24
by:
en | Academic Press Inc.,U.S.

0127098240 9780127098241 9780080866215

Vitamins and Hormones: Advances in Research and Applications: v. 24
By

Publisher: Academic Press Inc.,U.S.
Number Of Pages: 746
Publication Date: 1966-12
ISBN-10 / ASIN: 0127098240
ISBN-13 / EAN: 9780127098241

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The Art of Drug Synthesis
by: Douglas S. Johnson, Jie Jack Li
en

0471752150 9780471752158 9780470134962

Publisher: Wiley-Interscience
Number Of Pages: 276
Publication Date: 2007-07-09
Sales Rank: 286635
ISBN / ASIN: 0471752150
EAN: 9780471752158
Binding: Hardcover
Manufacturer: Wiley-Interscience
Studio: Wiley-Interscience

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.

Edited by prominent scientists working in drug discovery for Pfizer
Meets the needs of a growing community of researchers in pharmaceutical R&D
Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students
An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

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Vitamins and Hormones: Advances in Research and Applications: v. 20
by:
en | Academic Press Inc.,U.S.

0127098208 9780127098203 9780080866178

Vitamins and Hormones: Advances in Research and Applications: v. 20
By

Publisher: Academic Press Inc.,U.S.
Number Of Pages: 707
Publication Date: 1963-12
ISBN-10 / ASIN: 0127098208
ISBN-13 / EAN: 9780127098203

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Principles and Practice of Pharmacology for Anaesthetists, 5th edition
by Norman Calvey, Norton Williams

Principles and Practice of Pharmacology for Anaesthetists
By Norman Calvey, Norton Williams

Publisher: Wiley-Blackwell
Number Of Pages: 376
Publication Date: 2008-03-14
ISBN-10 / ASIN: 1405157275
ISBN-13 / EAN: 9781405157278
Binding: Hardcover

This fifth edition of Principles and Practice of Pharmacology for Anaesthetists continues to provide a comprehensive scientific basis and a readable account of the principles of pharmacology, as well as practical guidance in the use of drugs that is relevant to clinical anaesthesia.
With these concepts in mind:

Every chapter in this new edition has been thoroughly revised and updated

An additional chapter on Adverse Drug Reactions is included

For ease of reference, the structures of many commonly used agents are featured, with their sites of isomerism, when appropriate

Recommended International Non-proprietary Names (rINNs) are generally used for generic agents, although preference has been given to the current nomenclature for adrenaline and noradrenaline.

As in previous editions, a comprehensive glossary covering abbreviations and acronyms is included to aid the reader.

Principles and Practice of Pharmacology for Anaesthetists is an invaluable resource, both for candidates of professional examinations in anaesthesia and the practising anaesthetist wishing to refresh their pharmacological knowledge.

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VITAMINS AND HORMONES V16
by:
en | Elsevier

012709816X 9780127098166 9780080866130

VITAMINS AND HORMONES V16
By

Publisher: Elsevier
Number Of Pages: 437
Publication Date: 1958-01-01
ISBN-10 / ASIN: 012709816X
ISBN-13 / EAN: 9780127098166

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HPLC Methods for Recently Approved Pharmaceuticals
by: George Lunn
en

0471669415 9780471669418 9780471711674

HPLC Methods for Recently Approved Pharmaceuticals
By George Lunn

Publisher: Wiley-Interscience
Number Of Pages: 744
Publication Date: 2005-04-18
ISBN-10 / ASIN: 0471669415
ISBN-13 / EAN: 9780471669418

Product Description:

An indispensable resource for busy researchers

Your time is valuable-too valuable to spend hunting through the technical literature in search of the right HPLC assay techniques for your projects. With HPLC Methods for Recently Approved Pharmaceuticals, you’ll quickly identify and replicate the ideal procedures for your project needs, without having to refer to original source publications. More of your time can then be spent in the lab, not the library.

Covering the relevant world literature through 2003, this book picks up where Dr. Lunn’s acclaimed HPLC Methods for Pharmaceutical Analysis left off. It arms you with established HPLC assay techniques for hundreds of newly approved drugs, as well as drugs for which assay methods were only recently developed. Combining detailed descriptions of procedures with specially annotated references, this practical handbook gives you:
* HPLC methods for 390 commonly prescribed pharmaceutical compounds
* Various procedures for each drug listed together-making it easy to mix and match for customized approaches
* Methods for drugs in biological fluids and for bulk and formulated drugs
* Chemical structures, molecular weights and formulas, and CAS Registry Numbers
* Cross-references to The Merck Index
* Retention times of other drugs that can be assayed using the same methods

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Chromatography of Antibiotics (Journal of Chromatography Library)
by: Gerald H. Wagman, Marvin Joseph Weinstein

Chromatography of Antibiotics (Journal of Chromatography Library)
By Gerald H. Wagman, Marvin Joseph Weinstein

Publisher: Elsevier Science Ltd
Number Of Pages: 247
Publication Date: 1973-10
ISBN-10 / ASIN: 0444411062
ISBN-13 / EAN: 9780444411068
CHROMATOGRAPHIC CLASSIFICATION OF ANTIBIOTICS
Over the years many investigators have devised numerous procedures for classification
and identification of antibiotics by use of chromatographic techniques. In earlier years,
these various chromatographc systems were quite usuable because of the relatively small
number of antibiotics compared to the present. With the thousands of antibiotics
currently known, systematic chromatographic classification of this large number of
compounds is extremely difficult. It is possible to group many of these substances, but in
order to identify very closely related antibiotics in a particular group the use of many
additional chromatographic systems may be required. This book is not written as a means
of systematic chromatography but hopefully as an aid in identifying very similar compounds
by use of specific chromatographic techniques. A number of methods proposed for
classification of antibiotics into groups and within groups will be reviewed for use in the
preliminary or presumptive identification of some of these compounds. More definitive
identification should be possible by selective use of the index comprising the body of the
book.
In 1959 Miyazaki et al. described a method of grouping antibiotics according to their
salting out chromatograms. The antibiotics were examined by means of ascending paper
chromatography. As solvents, distilled water and increasing concentrations of ammonium
chloride (0.5 to 20% and saturated solution) were used. Location of the antibiotic zones
were determined by bioautographic methods. Using this technique the antibiotics were
divided into four major groups. In group A the Rf values were not correlated with the
concentration of the ammonium chloride solution, identical values being found at all
concentrations and in distilled water. Group B consisted of the antibiotics which had an
Rf value of 0 in distilled water and increasing Rf values with increasing concentrations of
ammonium chloride. Group C displayed the highest Rf value in distilled water and lowered
values with increasing concentration of the ammonium chloride solution. G ~ o u pD
consisted of antibiotics which did not display any movement whatever in the solvent
from the starting point. This systematic method was extended by Uri’ who added two
additional groups. Group E consisted of antibiotics which had an Rf value of 0 in
distilled water and an initial increase with rising concentrations of ammonium chloride
with the maximum (Rf approximately 1) in 5% salt solution. Beyond this a decrease
occurred. This type of paper chromatogram was typical for the macrolides such as
oleandomycin, erythromycin, and carbomycin. Within the macrolide group further
differentiation was possible. An additional grouping, F, was made, which at that time
consisted of only one antibiotic, desertomycin. By connecting the Rf values using a
variety of concentrations of ammonium chloride solution paraboloid curves were obtained
which were different for different antibiotics.
Paris and Theallet3 were able to separate 23 antibiotics which were described in the
French Pharmacopia into seven groups utilizing paper and TLC as well as electrophoresis.
The groups were as follows: (1) penicillin and derivatives, (2) heterocyclic compounds
containing amino groups such as the aminoglycosides, (3) macrolides, (4) tetracyclines,
( 5 ) chloramphenicol and viomycin, (6) polypeptides, and (7) polyenes.
into five groups according to a chromatographic scheme.
Blinov and co-workers4 in 1969 were able t o separate over 300 antibacterial preparations
into five groups according to a chromatographic scheme.

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Triumph of the Heart: The Story of Statins
by: Jie Jack Li

Triumph of the Heart: The Story of Statins
By Jie Jack Li

Publisher: Oxford University Press, USA
Number Of Pages: 224
Publication Date: 2009-04-03
ISBN-10 / ASIN: 0195323572
ISBN-13 / EAN: 9780195323573

Product Description:

Over 25 million people in the U.S. alone have benefited from statins–such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines–in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.

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The Psilocybin Solution
by: Simon G. Powell

PROLOGUE: Who or What Killed Einstein? - In which the fierce and ultimately fatal face of
Nature is outlined. It appears that each of us, temporarily orchestrated out of physics, chemistry
and biology, be enmeshed within a relentlessly sophisticated evolutionary process, a process which,
for some reason, the Universe was always poised to sustain. Along with Mr Einstein (before Nature
consumed him), we bravely ask why the Universe should be endowed with such a remarkable
capacity? Why on Earth should Nature have facilitated the eventual emergence of consciousness?
What kind of a phenomenal tease is this? We rightly demand that Nature provide us with some
answers! The seed of a new idea is here planted - namely that altered states of consciousness
derived from wholly natural environmental resources can allow us to interface more intimately
with such a user-friendly reality process. In this way, we might really get some answers as to the
point of it all……

CHAPTER ONE: Consuming God’s Flesh - When you go down to the woods today be sure you
know your shamanic history. Introducing our main man Robert Gordon Wasson and his extensive
ethnobotanical research into the historical use of entheogenic fungi and how he eventually came to
unearth the extraordinary vision-inducing Mexican psilocybin mushroom in the 1950’s. This
adventurous man thus warms us up for the main features to come. Nature, by jove, turns out to be
wilder than we could possibly imagine, and, more importantly, inherently transcendental. The
natural alchemical substance psilocybin, an alkaloid still new to Western science, reveals itself as a
potential key to unlocking the mysteries of consciousness.

CHAPTER TWO: An Ancient Form of Communion - Details concerning the use of psilocybin
mushrooms by the once mighty Aztec and Mayan civilisations. The alluring conjecture that the
spiritual impulse originated from our ancestors’ ingestion of vision-inducing plants is also
introduced.

CHAPTER THREE: Psilocybin flows in and out of the Western Mind - The true story of how the
60’s got rolling on the back of an entheogenic mushroom.

CHAPTER FOUR: Investigating the Earth’s Alchemical Skin - We learn more about the shamanic
use of entheogenic plants as well as previewing the second wave of human-based psychedelic
science.

CHAPTER FIVE: The Mushroom and the Synapse - In which we delve into the neuronal
architecture of the brain so as to comprehend more fully the nature and potential dynamics of
consciousness. Meet the neuron, the synapse, the neurotransmitter, and the cunning route through
which psilocybin operates.

CHAPTER SIX: The Stuff of Consciousness - The mystery of the mutable human mind is cracked
open and served up on a plate of profound implications. We see how the symbolic visionary
dialogue induced by entheogenic agents represents the coalescence and integration of vast amounts
of information. The felt presence of the transcendental Other is then delineated in informational
terms.

CHAPTER SEVEN: A Universe of Information - The mind/body dualism of Descartes is laid to
rest, as information reveals itself as the fundamental stuff of Nature with consciousness itself
representing a particular pattern of information embodied within the neuronal substrate of the
brain. An attempt is then made to conquer an understanding of the essential nature of information.

CHAPTER EIGHT: Does the Universe Compute? - If the entire reality process can be understood
as a dynamic flow of information (consciousness included), then what on Earth governs the ongoing
evolution of such an informational system or computation as it must surely be? We boldly
investigate.

CHAPTER NINE: Wrestling with Reality - The mystery of our smart and obligingly intelligible
Universe is openly debated. Evolution by natural selection is re-interpreted as being the
manifestation of Natural Intelligence, a property of Nature which ensures that information is
continually integrated and organised. It thus emerges that a smart algorithmic code be inherent in
the very contextual fabric of Nature. Upon reflection, it would appear that we have never had it so
good, especially once we begin to apprehend our true situation at the hands of Natural Intelligence.

CHAPTER TEN: A Neo-Shamanic Climax - A casual word on the Omega Point and the surprise
lurking at the end of history. In particular, are we the means through which the transcendental
Other awakens?

EPILOGUE: Trick or Treat? - A practical guide to ascertaining the truth of my fantastic claims
for, Goddess knows, I could have been wrong all along.

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The Psilocybin Solution
by: Simon G. Powell

PROLOGUE: Who or What Killed Einstein? - In which the fierce and ultimately fatal face of
Nature is outlined. It appears that each of us, temporarily orchestrated out of physics, chemistry
and biology, be enmeshed within a relentlessly sophisticated evolutionary process, a process which,
for some reason, the Universe was always poised to sustain. Along with Mr Einstein (before Nature
consumed him), we bravely ask why the Universe should be endowed with such a remarkable
capacity? Why on Earth should Nature have facilitated the eventual emergence of consciousness?
What kind of a phenomenal tease is this? We rightly demand that Nature provide us with some
answers! The seed of a new idea is here planted - namely that altered states of consciousness
derived from wholly natural environmental resources can allow us to interface more intimately
with such a user-friendly reality process. In this way, we might really get some answers as to the
point of it all……

CHAPTER ONE: Consuming God’s Flesh - When you go down to the woods today be sure you
know your shamanic history. Introducing our main man Robert Gordon Wasson and his extensive
ethnobotanical research into the historical use of entheogenic fungi and how he eventually came to
unearth the extraordinary vision-inducing Mexican psilocybin mushroom in the 1950’s. This
adventurous man thus warms us up for the main features to come. Nature, by jove, turns out to be
wilder than we could possibly imagine, and, more importantly, inherently transcendental. The
natural alchemical substance psilocybin, an alkaloid still new to Western science, reveals itself as a
potential key to unlocking the mysteries of consciousness.

CHAPTER TWO: An Ancient Form of Communion - Details concerning the use of psilocybin
mushrooms by the once mighty Aztec and Mayan civilisations. The alluring conjecture that the
spiritual impulse originated from our ancestors’ ingestion of vision-inducing plants is also
introduced.

CHAPTER THREE: Psilocybin flows in and out of the Western Mind - The true story of how the
60’s got rolling on the back of an entheogenic mushroom.

CHAPTER FOUR: Investigating the Earth’s Alchemical Skin - We learn more about the shamanic
use of entheogenic plants as well as previewing the second wave of human-based psychedelic
science.

CHAPTER FIVE: The Mushroom and the Synapse - In which we delve into the neuronal
architecture of the brain so as to comprehend more fully the nature and potential dynamics of
consciousness. Meet the neuron, the synapse, the neurotransmitter, and the cunning route through
which psilocybin operates.

CHAPTER SIX: The Stuff of Consciousness - The mystery of the mutable human mind is cracked
open and served up on a plate of profound implications. We see how the symbolic visionary
dialogue induced by entheogenic agents represents the coalescence and integration of vast amounts
of information. The felt presence of the transcendental Other is then delineated in informational
terms.

CHAPTER SEVEN: A Universe of Information - The mind/body dualism of Descartes is laid to
rest, as information reveals itself as the fundamental stuff of Nature with consciousness itself
representing a particular pattern of information embodied within the neuronal substrate of the
brain. An attempt is then made to conquer an understanding of the essential nature of information.

CHAPTER EIGHT: Does the Universe Compute? - If the entire reality process can be understood
as a dynamic flow of information (consciousness included), then what on Earth governs the ongoing
evolution of such an informational system or computation as it must surely be? We boldly
investigate.

CHAPTER NINE: Wrestling with Reality - The mystery of our smart and obligingly intelligible
Universe is openly debated. Evolution by natural selection is re-interpreted as being the
manifestation of Natural Intelligence, a property of Nature which ensures that information is
continually integrated and organised. It thus emerges that a smart algorithmic code be inherent in
the very contextual fabric of Nature. Upon reflection, it would appear that we have never had it so
good, especially once we begin to apprehend our true situation at the hands of Natural Intelligence.

CHAPTER TEN: A Neo-Shamanic Climax - A casual word on the Omega Point and the surprise
lurking at the end of history. In particular, are we the means through which the transcendental
Other awakens?

EPILOGUE: Trick or Treat? - A practical guide to ascertaining the truth of my fantastic claims
for, Goddess knows, I could have been wrong all along.

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Dielectric Analysis of Pharmaceutical Systems
by: Craig Duncan Q. M.
en | Taylor & Francis, Inc.

0203302575 9780203302576 9780203354452

Dielectric Analysis of Pharmaceutical Systems
By Craig Duncan Q. M.

Publisher: Taylor & Francis, Inc.
Publication Date: 1995-11-01
ISBN-10 / ASIN: 0203302575
ISBN-13 / EAN: 9780203302576

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Dielectric Analysis of Pharmaceutical Systems
by: Craig Duncan Q. M.
en | Taylor & Francis, Inc.

0203302575 9780203302576 9780203354452

Dielectric Analysis of Pharmaceutical Systems
By Craig Duncan Q. M.

Publisher: Taylor & Francis, Inc.
Publication Date: 1995-11-01
ISBN-10 / ASIN: 0203302575
ISBN-13 / EAN: 9780203302576

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Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects
by: Gideon Maxwell Polya
en | Taylor & Francis, Inc.

0203013719 9780203013717 9780203351383

Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects
By Gideon Maxwell Polya

Publisher: Taylor & Francis, Inc.
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ISBN-10 / ASIN: 0203013719
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Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects
by: Gideon Maxwell Polya
en | Taylor & Francis, Inc.

0203013719 9780203013717 9780203351383

Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects
By Gideon Maxwell Polya

Publisher: Taylor & Francis, Inc.
Publication Date: 2003-05-01
ISBN-10 / ASIN: 0203013719
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Progress in Medicinal Chemistry
by: G P Ellis, Geoffrey Buckle West
en | Butterworth

0408700130 9780408700139 9780080862552

Progress in Medicinal Chemistry
By G P Ellis, Geoffrey Buckle West

Publisher: Butterworth
Number Of Pages: 212
Publication Date: 1970-07
ISBN-10 / ASIN: 0408700130
ISBN-13 / EAN: 9780408700139

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Progress in Medicinal Chemistry
by: G P Ellis, Geoffrey Buckle West
en | Butterworth

0408700130 9780408700139 9780080862552

Progress in Medicinal Chemistry
By G P Ellis, Geoffrey Buckle West

Publisher: Butterworth
Number Of Pages: 212
Publication Date: 1970-07
ISBN-10 / ASIN: 0408700130
ISBN-13 / EAN: 9780408700139

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Progress in Medicinal Chemistry, Volume 28
by: G. P. Ellis
en | Not Avail

044481275X 9780444812759

Progress in Medicinal Chemistry, Volume 28
By G. P. Ellis

Publisher: Not Avail
Number Of Pages: 360
Publication Date: 1991-06
ISBN-10 / ASIN: 044481275X
ISBN-13 / EAN: 9780444812759

Product Description:

The six reviews in this volume cover once again a most comprehensive range of topics. The anti-malarial activity of the 8-aminoquinolines is examined, with an eye to the development of a single, broad-spectrum drug. Chelation, important in removal of toxic metals from the body, is reviewed for tripositive elements. A new and promising approach to total parenteral nutrition is described. Our indebtedness to the plant origins of many modern drugs is noted in the context of new chemicals. Heterosteroids and receptor-specific opioid peptides constitute two further topics, each case highlighting the wide range of relevant biologically active compounds. Yet another volume challenging the staggering diversity of the field of medicinal chemistry.

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Progress in Medicinal Chemistry, Volume 28
by: G. P. Ellis
en | Not Avail

044481275X 9780444812759

Progress in Medicinal Chemistry, Volume 28
By G. P. Ellis

Publisher: Not Avail
Number Of Pages: 360
Publication Date: 1991-06
ISBN-10 / ASIN: 044481275X
ISBN-13 / EAN: 9780444812759

Product Description:

The six reviews in this volume cover once again a most comprehensive range of topics. The anti-malarial activity of the 8-aminoquinolines is examined, with an eye to the development of a single, broad-spectrum drug. Chelation, important in removal of toxic metals from the body, is reviewed for tripositive elements. A new and promising approach to total parenteral nutrition is described. Our indebtedness to the plant origins of many modern drugs is noted in the context of new chemicals. Heterosteroids and receptor-specific opioid peptides constitute two further topics, each case highlighting the wide range of relevant biologically active compounds. Yet another volume challenging the staggering diversity of the field of medicinal chemistry.

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Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells (Methods in Molecular Medicine)
by: Mark J. Jaroszeski

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells (Methods in Molecular Medicine)
By Mark J. Jaroszeski

Publisher: Humana Press
Number Of Pages: 512
Publication Date: 2000-02-18
ISBN-10 / ASIN: 0896036065
ISBN-13 / EAN: 9780896036062

Product Description:

Univ. of South Florida, Tampa. Provides reviews of critical aspects of the subject, including the history, current state, and future implications of work using electric fields to deliver molecules in vivo. Also focuses on protocols used for the delivery of molecules into cells and through the skin.

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Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells (Methods in Molecular Medicine)
by: Mark J. Jaroszeski

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By Mark J. Jaroszeski

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Progress in Medicinal Chemistry : Volume 30
by: G. P. Ellis
en | Elsevier Science Pub Co

Progress in Medicinal Chemistry : Volume 30
By G. P. Ellis

Publisher: Elsevier Science Pub Co
Number Of Pages: 404
Publication Date: 1993-08-01
ISBN-10 / ASIN: 0444899898
ISBN-13 / EAN: 9780444899897

Product Description:

In this volume, the medicinal chemistry of the rapidly expanding family of retinoids, of promising semi-synthetic erythromycins and of the multifaceted amidines is reviewed. Another chapter continues the coverage of inorganic elements which have a medical role; recent studies on the various biological roles of manganese are also examined. Inhibition of enkephalin-degrading enzymes is reviewed, as are studies of the digitalis recognition site which are expected to lead to the development of more highly selective inotropic drugs. This work should be of value to medicinal chemists, pharmacists and pharmacologists. It should also be appreciated by all newcomers, as well as those who wish to be kept up to date with recent work on these topics.

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Progress in Medicinal Chemistry : Volume 30
by: G. P. Ellis
en | Elsevier Science Pub Co

Progress in Medicinal Chemistry : Volume 30
By G. P. Ellis

Publisher: Elsevier Science Pub Co
Number Of Pages: 404
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In this volume, the medicinal chemistry of the rapidly expanding family of retinoids, of promising semi-synthetic erythromycins and of the multifaceted amidines is reviewed. Another chapter continues the coverage of inorganic elements which have a medical role; recent studies on the various biological roles of manganese are also examined. Inhibition of enkephalin-degrading enzymes is reviewed, as are studies of the digitalis recognition site which are expected to lead to the development of more highly selective inotropic drugs. This work should be of value to medicinal chemists, pharmacists and pharmacologists. It should also be appreciated by all newcomers, as well as those who wish to be kept up to date with recent work on these topics.

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Vitamins and Hormones: Advances in Research and Applications: v. 8
by:
en | Academic Press Inc.,U.S.

0127098089 9780127098081 9780080866055

Vitamins and Hormones: Advances in Research and Applications: v. 8
By

Publisher: Academic Press Inc.,U.S.
Number Of Pages: 342
Publication Date: 1950-12
ISBN-10 / ASIN: 0127098089
ISBN-13 / EAN: 9780127098081

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Vitamins and Hormones: Advances in Research and Applications: v. 8
by:
en | Academic Press Inc.,U.S.

0127098089 9780127098081 9780080866055

Vitamins and Hormones: Advances in Research and Applications: v. 8
By

Publisher: Academic Press Inc.,U.S.
Number Of Pages: 342
Publication Date: 1950-12
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Psychotropic Substances: Statistics for 2004-assessments of Annual Medical And Scientific Requirements for Substances in Schedules Ii, III And IV
by: United Nations

Psychotropic Substances: Statistics for 2004-assessments of Annual Medical And Scientific Requirements for Substances in Schedules Ii, III And IV
By

Publisher: United Nations Pubns
Number Of Pages: 344
Publication Date: 2006-04
ISBN-10 / ASIN: 9210481097
ISBN-13 / EAN: 9789210481090

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Developing a National Registry of Pharmacologic and Biologic Clinical Trials: Workshop Report
by: Committee on Clinical Trial Registries

Developing a National Registry of Pharmacologic and Biologic Clinical Trials: Workshop Report
By Committee on Clinical Trial Registries

Publisher: National Academies Press
Number Of Pages: 124
Publication Date: 2006-06-16
ISBN-10 / ASIN: 030910078X
ISBN-13 / EAN: 9780309100786

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Provides workshop report of the Committee on Clinical Trial Registries Board on Health Sciences Policy held June 27, c2005. Topics include the need for clinical trial registries, current registry activities, content of a clinical trial registry, implementation issues, and more. For researchers. Softcover.

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2006 World Drug Report, Volume 1: Analysis
by: United Nations Office for Drug Control and Crime Prevention Staff

2006 World Drug Report, Volume 1: Analysis
By United Nations Office for Drug Control and Crime Prevention Staff

Publisher: United Nations Publications
Publication Date: 2006-01-01
ISBN-10 / ASIN: 9211482143
ISBN-13 / EAN: 9789211482140

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Pharmacracy: Medicine and Politics in America
by: Thomas Szasz

Pharmacracy: Medicine and Politics in America
By Thomas Szasz

Publisher: Praeger Trade
Number Of Pages: 240
Publication Date: 2001-07
ISBN-10 / ASIN: 0275971961
ISBN-13 / EAN: 9780275971960

Product Description:

In recent decades, American medicine has become increasingly politicized and politics has become increasingly medicalized. Behaviors previously seen as virtuous or wicked, wise or unwise are now dealt with as "healthy" or "sick"–unwanted behaviors to be controlled as if they were public health issues. The modern penchant for transforming human problems into "diseases" and judicial sanctions into "treatments," replacing the rule of law with the rule of medical discretion, leads to a type of government social critic Thomas Szasz calls "pharmacracy." This insidious political development is eroding our personal liberties while distorting our approach to both health care and politics.

Summary: Quack!
Rating: 1

Szasz and the reviewers fo this book have obviously never suffered from nor known anyone who suffers from a serious mental illness. Far from being just bad or unwanted behaviors or ‘fake diseases’, mental illness is a devastating disease that ruins lives and often kills its victims.
After years of denial and attemps to control my own behavior, my life spun out ot control and I went from a respected professional in my community to a manic-depressive psychotic, roaming the streets delusional, completely out of touch with reality. It took commitment to the state mental hospital to give me some insight into my problem.
Thanks to the drugs that Szasz and others find so questionable, I am now able to lead a normal, stable life. Without the progress made in pharmacology in the last thirty years many people like me would be confined to mental institutions for extended periods or permanently.
This book is nothing more than a rant by an elderly doctor who needs to catch up with the real world. There is much still to be learned about brain function and the mechanisms of these disorders, but the fact that we don’t have all the answers yet doesn’t mean that they aren’t out there. Or should I say in there?
Unless you don’t want to be pulled back into the ninteenth century, steer clear of this book. Szasz is quackers!

Summary: The Politics of Medicine
Rating: 5

This is a great book for laying to rest some orthodox but wrong ideas about our mental health. Szasz shows us that the orthodox way is not necessarily the right way. Certainly our own doctors are not going to blow the whistle on themselves, are they? This revolutionary psychiatrist shows us the real path to health, pointing us away from the wrong direction that the pharmaceutical companies have been leading us, and unfortunately, leading our doctors as well. It’s a case of the fox guarding the henhouse.
Do you care that a psychiatrist is a doctor who prescribes drugs to change people’s brains without ever actually examining those people’s brains? Do you worry that nobody knows exactly what the long-term effect of these drugs are that we are now being given for bi-polar disorder, for attention deficit disorder, for depression or for anxiety; or even if they are really doing us more harm than good? Do you know how doctors today are becoming more and more controlled and subverted by the pharmaceutical industry? Do you think that unwanted behavior and unwanted feelings like anxiety and depression are diseases that can be cured by drugs? If you do, you should read the latest book by this world renowned psychiatrist.
"Psychiatrists have a long history of systematically validating fake diseases as real diseases, and getting away with it," says Szasz. They can get away with it because it serves everybody: the family whose medical insurance will pay only for certain diagnoses and not for others; the government officials who can allocate more and more federal funds for their universities and laboratories; and the doctors who can service many more patients in the "service station" atmosphere that has us all believing that everything can be made right with the right pill. The only person whom fake diagnoses and powerful drugs are not serving is the health of the individual who is having his birthright sold for a pharmaceutical mess of pottage.
We are confusing, warns Szasz, bodily diseases which are physiochemical phenomena located in the body and understood by cellular pathology with unwanted personal habits or behaviors which are located in the social context of society and understood by the interconnecting relationships. We are confusing the mind with the brain. And finally, we are confusing medicine with politics and social agenda. In so doing we are becoming less and less the land of the free and the brave and more and more the land of the mentally ill and deluded. Szasz makes a good case for a new look at the insidious subversion of our medical care by the politics of pharmaceutical managed care.

Summary: this book could save your life
Rating: 5

Pharmacracy

Do you care that a psychiatrist is a doctor who prescribes drugs to change people’s brains without ever actually examining those people’s brains? Do you worry that nobody knows exactly what the long-term effect of these drugs are that we are now being given for bi-polar disorder, for attention deficit disorder, for depression or for anxiety; or even if they are really doing us more harm than good? Do you know how doctors today are becoming more and more controlled and subverted by the pharmaceutical industry? Are unwanted behavior and unwanted feelings like anxiety and depression diseases that can be cured by drugs? If you think they are, please run as fast as you can and get this book. It could save your life.

Summary: Thomas Szasz Does It Again
Rating: 5

Dr. Szasz, now 81 years old, has done it again: explained what’s going on in the minds of psychiatrists and their adulators from the Surgeon General on down. And why.

For example, he tells us how doctors are really paid and explains the corrupting effect of third party reimbursement by DRG (Diagnosis Related Groups)on the most important and the kindest thing any doctor can do: make an accurate diagnosis.

There are new insights, new quotes and the usual entertaining anecdotes and fastidious footnotes.

Psychiatric obscurantism is impacting every American every time he or she is misinformed: "Depression is a disease like diabetes - ask your Doctor about…." And that’s just TV.

What kills me is how the parrots of psychobaffle preen themselves on their courage at having broken through the mind body barrier - as if obliterating one of childhood’s most important lessons - that thinking doesn’t make it so - is an accomplishment to squawk over: "Look Mom, I can fly."

How dumb can we get? Read this book and find out. The bamboozlement of Mental Health already is to the 21st Century what the propaganda of Communism and National Socialism were to the 20th. Immunize yourself now.

Dr. Szasz has been one of the clearest thinkers and writers for 50 years and this book is another brilliant facet to the immense diamond which is his life’s work.

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Pharmaceutical Biotechnology
by: Daan J.A. Crommelin, Robert D. Sindelar
en | CRC

0415285003 9780415285001 0415285011 9780415285018 020330103X 0203355466

Pharmaceutical Biotechnology
By Daan J.A. Crommelin, Robert D. Sindelar

Publisher: CRC
Number Of Pages: 600
Publication Date: 2002-12
ISBN-10 / ASIN: 0415285003
ISBN-13 / EAN: 9780415285001
Review
Conceiving an up-to-date pharmaceutical biotechnology textbook that trains next-generation pharmacy students, as well as updating pharmacists and pharmaceutical scientists … is a formidable challenge, and one which the editors … have accomplished to a high standard … . … [Many chapters] contain industrial case-studies of blockbuster drugs, thus giving this textbook an industrial scope that is difficult to find elsewhere. All the chapters are easy to read and well illustrated to aid understanding of the interdisciplinary content. Each chapter is authored by experts in the field and contains a good introductory section and an in-depth discussion of each topic.
- Drug Discovery Today, Vol. 8, No. 17, Sept. 2003

Product Description
The field of pharmaceutical biotechnology is a rapidly evolving subject. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for a spectrum of serious diseases such as cancer, viral infections, cardiovascular and hereditary disorders. In addition, we are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy.
Completely revised and updated, this introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use.

About the Author
Daan J.A. Crommelin is at Utrecht University in The Netherlands. Robert D. Sindelar is at the University of Mississippi School of Pharmacy in the USA.

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Pharmaceutical Analysis (Sheffield Analytical Chemistry Series)
by:
en

184127335X 9781841273358

Pharmaceutical Analysis (Sheffield Analytical Chemistry Series)
By

Publisher:
Number Of Pages: 384
Publication Date:
ISBN-10 / ASIN: 184127335X
ISBN-13 / EAN: 9781841273358

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Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, & Other Psychedelic Amphetamines
by: Fester, Uncle Fester, Uncle Fester

Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, & Other Psychedelic Amphetamines
By Fester, Uncle Fester, Uncle Fester

Publisher: Loompanics Unlimited
Number Of Pages: 183
Publication Date: 1999-09
ISBN-10 / ASIN: 1559501820
ISBN-13 / EAN: 9781559501828

Product Description:

For nearly 20 years now I have been training champions, the champions of the field of clandestine chemistry. This book is their training ground.

I cover virtually every possible method of making that "food of the God’s" - meth along with how to make it from commonplace materials. I also give coverage of the history of this field, so that newcomers can quickly feel like old pros.

Beyond that, I also supply news inserts with the books so that the latest patents don’t leave you in the dust in this rapidly evolving field. This is the place to get up to speed and up to date in this hot area of study.

Summary: Needs more work
Rating: 2

I think the book lacked proper illustrations. In one instance the author refers to a black and white sketch when he says "Making a claisen adapter, as shown in figure 5, is self explanatory". It looks like there is a cork on one end but what material is the rest made of? When working with chemicals, the material your equiptment is made of can be crucial or lifesaving.The author often gets sidetracked with different versions of a recipe. Maybe a different edition would be better?

Summary: Can’t Find Book Read This
Rating: 5

This is a great book that is a little inaccessible to newby chemists, but it’s about as simple as the process can be explained. And if you can’t understand it you’re liable to blow yourself up so I would try something else, theoretically speaking. Since Amazon wont sell this I would direct all interested parties to the Loompanics Unlimited catalog. That’s a great catalog in general, and it sells the most updated edition of this book plus others by the author. It also has several other great books. Cheers.

Summary: Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, and Other Psychedelic Amphetamines
Rating: 3

while the info is really in this book, it is very hard to read an I feel could be written in more of a layman’s term.

Summary: Study hard…
Rating: 5

Finally a resource for the "cooks" out there who know absolutely nothing about what they are doing and end up blowing up their house, or worse yet, their children. "Joe Blow" next door decides he’s gonna make some meth and then the cash will roll in, ignoring the fact that the chemicals he’s bringing into the neighborhood could very well kill. Maybe, just maybe, this book can cut the casualties of production.

Summary: Secrets of Methamphetamine Manufacture
Rating: 5

This is a wonderful compilation of valuable information by one the great american pioneers of our time! Uncle Fester is the reigning king of the underground enthusiast!

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Annual Review of Pharmacology and Toxicology Volume 45, 2005 (Annual Review of Pharmacology and Toxicology)
by: Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Horace H. Loh

Annual Review of Pharmacology and Toxicology Volume 45, 2005 (Annual Review of Pharmacology and Toxicology)
By Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Horace H. Loh

Publisher: Annual Reviews
Number Of Pages: 787
Publication Date: 2005-02-10
ISBN-10 / ASIN: 0824304454
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Side Effects of Drugs Annual 14, 1990: A Worldwide Yearly Survey of New Data and Trends (v. 14)
by: M. N. G. Dukes

Side Effects of Drugs Annual 14, 1990: A Worldwide Yearly Survey of New Data and Trends (v. 14)
By M. N. G. Dukes

Publisher: Not Avail
Number Of Pages: 504
Publication Date: 1990-12
ISBN-10 / ASIN: 0444813462
ISBN-13 / EAN: 9780444813466

Product Description:

The expert team of authors and editors working on the series have once again critically reviewed the vast amount of data on adverse drug reactions appearing annually. The Side Effects of Drugs Annual provides a complete overview of all known side effects of drugs, both major and obscure.

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Research Strategies for Assessing Adverse Events Associated with Vaccines
by: Kathleen R. Stratton, Cynthia J. Howe, Richard B. Johnston(eds.)
en | NATIONAL ACADEMY PRESS

Title: Research Strategies for Assessing Adverse Events Associated with Vaccines
Authors: Kathleen R. Stratton, Cynthia J. Howe, Richard B. Johnston(eds.)
Publisher: National Academy Press
Date: 1994
Pages: 30

In sum, there was agreement that more consideration needs to be given
to the use and utility of case reports, including those submitted to passive
surveillance systems, that the role of clinical trials (including postmarketing
studies) is limited due to frequent lack of randomization and small sample
size, and that LLDBs show great but not unlimited promise. Vaccine safety
must be studied on an ongoing basis and with a variety of tools, including
basic research.

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Handbook of Microbiological Quality Control in Pharmaceuticals and Medical Devices (Taylor & Francis Series in Pharmaceutical Sciences)
by: Rosamund M. Baird, Norman A. Hodges, Stephen P. Denyer.
en | Taylor & Francis

9780203305195 9780203351925 0203305191 0203351924 074840614X

Handbook of Microbiological Quality Control in Pharmaceuticals and Medical Devices (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES)
By Rosamund M. Baird, Norman A. Hodges, Stephen P. Denyer

Publisher: CRC
Number Of Pages: 280
Publication Date: 2000-08-17
ISBN-10 / ASIN: 074840614X
ISBN-13 / EAN: 9780748406142

Product Description:

This book will be a practical guide to techniques used in microbial quality assurance in the pharmaceutical industry. It aims to fill the gap in the literature between food and medical microbiology techniques books.

Summary: Microbiology
Rating: 5

Handbook of methods for microbiological quality control in pharmaceutical and medical devices

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LSD-25 & Tryptamine Syntheses Overview & Reference Guide for
by: Otto Snow

LSD-25 & Tryptamine Syntheses Overview & Reference Guide for
By Otto Snow

Publisher: Thoth Press
Number Of Pages: 131
Publication Date: 1998-06-02
ISBN-10 / ASIN: 0966312813
ISBN-13 / EAN: 9780966312812

Product Description:

is the most comprehensive reference guide on the syntheses of LSD-25. Reactions are described including a review of the Task Force Report: Narcotics and Drug Abuse, Annotations and Consultants’ Papers. Many of the reactions include: Synthesis of N,N-dialkyl substututed lysergamides. The Curtis Reaction. Preparation of d-iso-lysergic acid hydrazide; d-iso-lysergic acid azide; d-iso-LSD.

The Garbrecht Synthesis. Epimerization of d-iso-LSD into d-LSD. Fractional crystallization of LSD-25. Separation of d-lysergamides from d-iso-lysergamides. Alternative syntheses of lysergamides. Ergoline alkaloids from Rivea Corymbosa; morning glories; Argyreia nervosa. Life history and poisonus properties of Claviceps paspali. Host plants to Claviceps paspali. Host plants resistant to artificial inoculation of Claviceps paspali. Developing Claviceps purpurea. Claviceps purpurea cultivation and strain selection. Preparation of media. Inoculation of cultures. Alkaloid production by Claviceps cultures. More fermentations. Alkaloid extraction from cultures. Recrystallization of lysergic acid. Lysergic acid from Claviceps culture. Field inoculation of rye with Claviceps purpurea. Preparation of ethylamine and diethylamine. Preparation of ethyl bromide. Preparation of hydrazine sulfate and anhydrous hydrazine. Tablet manufacture. Molded tablets. Tablet machine. Compressed tablets. Preparation of "Clearlight" Carrier: "sheeting". Blotter carrier. N,N-Dialkyltryptamines and substituted alpha-alkyl and N,N-dialkyltryptamines. Psilocin from psilocybin containing mushrooms. Increasing psilocybin & psilocin content of cultivated mushrooms using tryptamine. Preparation of N,N-dialkyltryptamines. Preparation of tryptamine from tryptophan. Preparation of alpha, alpha-dialkyltryptamines. Electrolytic reduction of 3-(2-nitro-vinyl)indole to prepare tryptamine. Syntheses of gramine and analogs. Alternative syntheses of tryptamines. Preparation of substituted indoles. Melatonin. Adrenoglomerulotropin. Harman; harmaline; harmalol; harmine; harmol. Neurotoxic tryptamines. Future research. Over 225 references to scientific and medical journal articles. Indexed.

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Encyclopedia of Pharmaceutical Technology, Volume 20
by: James Swarbrick, James C. Boylan

Encyclopedia of Pharmaceutical Technology, Volume 20
By James Swarbrick, James C. Boylan

Publisher: Informa HealthCare
Number Of Pages: 500
Publication Date: 2000-12-05
ISBN-10 / ASIN: 082472819X
ISBN-13 / EAN: 9780824728199
Product Description
AAI, Inc., Wilmington, NC. An encyclopedia of pharmaceutical technology, offering a collection of entries on a number of subjects, from drug delivery to process chemistry in the pharmaceutical industry. Lists the contents for all 20 volumes in the set. DNLM: Chemistry, Pharmaceutical-encyclopedias.

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Magic Molecules: How Drugs Work
by: Susan Aldridge
en | Cambridge University Press

0521584140 9780521584142 9780511001307

Magic Molecules: How Drugs Work
By Susan Aldridge

Publisher: Cambridge University Press
Number Of Pages: 284
Publication Date: 1998-09-28
ISBN-10 / ASIN: 0521584140
ISBN-13 / EAN: 9780521584142

Product Description:

We have all been drug users at one time or another. Drugs can be used as medicines, as food additives, for pleasure, and to protect our long-term health. With so many new drugs on the market and an ever-widening definition of what exactly makes a drug a drug, we should all be well informed about the drugs we use–how they work, their benefits, and their risks. This book is a unique guide for the general reader to the drugs of everyday life–from commonly prescribed medicines to recreational drugs (including illicit ones) and food supplements. The author examines how drugs interact with their targets in the body, where drugs come from, how they are developed, and what new kinds of drugs are on the horizon. She reviews all the major pharmaceutical medicines–painkillers, antibiotics, anti-cancer drugs, anti-depressants, heart drugs, tranquilizers, and hormones. Much more than a consumer handbook, this volume conveys the fascinating science behind drugs in an easily accessible way.

Amazon.com Review:

Almost all of us have used medical drugs at some point to help make us well, or at least to help us feel better while we endure our illnesses. Yet most of them are mysterious to us, even those that are thoroughly understood by scientists. Susan Aldridge wrote Magic Molecules: How Drugs Work as a guide for scientifically literate consumers to help us understand these chemicals and their effects on our bodies. Looking at painkillers, antibiotics, cancer therapies, "smart drugs," and many others, she uses clear, plain language and illustrations to describe the mechanisms of these medications.

But Magic Molecules is no encyclopedia. Aldridge includes fascinating discussions of related topics such as viral diseases, clinical trials, and the history of drug use, interwoven with her descriptions of the drugs we use each day. How does ibuprofen differ from aspirin? Why does chemotherapy make us sick? How come pregnant women have to be so careful with their medications? These questions and more are answered in this book that combines the usefulness of a reference text with the delightful charm of the best scientific works. –Rob Lightner

Summary: A review of Magic Molecules
Rating: 4

This book is to be commended for its, clarity of thought ,and flowing prose in its treatment of a subject both broad in scope ,and complex in nature. The Author is able to give the reader an accessible overview of the of the most common diseases affecting mankind, and the of the pharmacological approaches used to combat these illnesses in a manner that deftly maneuvers in level from the molecular to the practical. The only reason that I didn’t give this book 5 stars is because that I reserve such a rating in this genre for a masterpiece such as "Creating Mind:How the Brain Works"

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Drug Discovery: A History
by: Walter Sneader
en

0471899798 9780471899792 9780470015520

Drug Discovery: A History
By Walter Sneader

Publisher: Wiley
Number Of Pages: 472
Publication Date: 2005-06-23
Sales Rank: 1381677
ISBN / ASIN: 0471899798
EAN: 9780471899792
Binding: Hardcover
Manufacturer: Wiley
Studio: Wiley
Average Rating:
Total Reviews:

——————————————————————————–

Book Description:

Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.

This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society.

Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research.

Hallmark features:

Up-to-the-minute information in drug research
Vignettes of special and unusual information, and anecdotes
Discusses drug prototypes from all sources
More comprehensive than other volumes on history of drug discovery
From the reviews:

"…an excellent bibliographic resource for those interested in the background papers that serve as the foundation for discovery of specific drug entities." JOURNAL OF MEDICAL CHEMISTRY, June 2006

"…a very comprehensive overview of drug development. It should be on the shelf on any aspiring pharmacist, medicinal chemist, or person interested in the history of therapeutic agents." JOURNAL OF CHEMICAL EDUCATION, February 2006

"…a very readable and closely researched book…" CHEMISTRY & INDUSTRY, October 2005

Download Description:

Written by a leading authority with an excellent reputation, and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures. This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society. Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research. Features: Up-to-the-minute information in drug research Vignettes of special and unusual information, and anecdotes Discusses drug prototypes from all sources More comprehensive than other volumes on history of drug discovery Also available in paperback.

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The Antioxidant Vitamins C and E
by: L. Packer, M.G. Traber, K. Kraemer, B. Frei

The Antioxidant Vitamins C and E
By Lester Packer

Publisher: AOCS Publishing
Number Of Pages: 298
Publication Date: 2002-01-30
ISBN-10 / ASIN: 1893997294
ISBN-13 / EAN: 9781893997295

Clearly, the areas of greatest interest for both the public and the scientific community are the roles of vitamins C and E in disease prevention, in retarding the progression of age-related chronic and degenerative disorders, and in promoting healthy aging. The introductory chapters provide a concise historical background of vitamins C and E and summarize many important discoveries concerning their biological functions and their roles in prevention of dietary deficiency, chronic disease and oxidative stress. Other chapters detail current research on the biological actions of vitamins C and E in biochemical, cell and physiological systems, and their roles in antioxidative stress-related diseases and disorders. These latter chapters highlight the importance of vitamins C and E in metabolic and inflammatory disorders, in agerelated diseases and in healthy aging.

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Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy (Practical Spectroscopy)
by: Emil W. Ciurczak, III, James K. Drennen,
en

0824794532 9780824794538 9780585408088

By Emil W. Ciurczak, III, James K. Drennen,

Publisher: CRC
Number Of Pages: 208
Publication Date: 2002-02-08
Sales Rank: 1445594
ISBN / ASIN: 0824794532
EAN: 9780824794538
Binding: Hardcover
Manufacturer: CRC
Studio: CRC
Average Rating:
Total Reviews:

This book discusses the theory, instrumentation, validation, and implementation of near-infrared spectroscopy for pharmaceutical and medical applications. It showcases a diverse range of contemporary methods for the production, screening, and analysis of new drug products and pharmaceuticals. Presents current approaches in near-infrared spectroscopy (NIR) to monitor and control multiple phases of the drug manufacturing process.

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Burger’s Medicinal Chemistry and Drug Discovery, Nervous System Agents (Volume 6)
by: Donald J. Abraham

Burger’s Medicinal Chemistry and Drug Discovery, Nervous System Agents (Volume 6)
By Donald J. Abraham

Publisher: Wiley-Interscience
Number Of Pages: 1104
Publication Date: 2003-03-07
ISBN-10 / ASIN: 0471274011
ISBN-13 / EAN: 9780471274018

Product Description:

This is Volume 6: Nervous System Agents, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Alzheimer’s Disease: Search for Therapeutics, Cognition Enhancers and Drugs to Treat Eating and Body Weight Disorders.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.

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Burger’s Medicinal Chemistry and Drug Discovery, Chemotherapeutic Agents (Volume 5)
by: Donald J. Abraham

Burger’s Medicinal Chemistry and Drug Discovery, Chemotherapeutic Agents (Volume 5)
By Donald J. Abraham

Publisher: Wiley-Interscience
Number Of Pages: 1152
Publication Date: 2003-03-06
ISBN-10 / ASIN: 0471370312
ISBN-13 / EAN: 9780471370314

Product Description:

This is Volume 5: Chemotherapeutic Agents, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Molecular Biology of Cancer, Synthetic Anti-angiogenic Agents and Selective Toxicities.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.

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Burger’s Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1)
by: Donald J. Abraham

Burger’s Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1)
By Donald J. Abraham

Publisher: Wiley-Interscience
Number Of Pages: 960
Publication Date: 2003-01-17
ISBN-10 / ASIN: 0471270903
ISBN-13 / EAN: 9780471270904

Product Description:

This is Volume 1: Drug Discovery, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.

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Burger’s Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2)
by: Donald J. Abraham

Burger’s Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2)
By Donald J. Abraham

Publisher: Wiley-Interscience
Number Of Pages: 832
Publication Date: 2003-01-23
ISBN-10 / ASIN: 0471370282
ISBN-13 / EAN: 9780471370284

Product Description:

This is Volume 2: Drug Discovery and Drug Development, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.

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Burger’s Medicinal Chemistry and Drug Discovery, 6 Volume Set
by: Donald J. Abraham
en

0471370320 9780471370321

Burger’s Medicinal Chemistry (Volume 1-6)
5568 pages Wiley-Interscience; 6 edition

Book Description
An essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research.†Journal of Medicinal Chemistry on the Fifth Edition This new edition of Dr. Alfred Burgers internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred in the field, this latest edition brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery now in use around the world. This Sixth Edition of Burgers Medicinal Chemistry and Drug Discovery has been expanded to six volumes:

Volume 1: Drug Discovery
Volume 2: Drug Discovery and Drug Development
Volume 3: Cardiovascular Agents and Endocrines
Volume 4: Autocoids, Diagnostics, and Drugs from New biology
Volume 5: Chemotherapeutic Agents
Volume 6: Nervous System Agents

Saludos
Daniel

posted by reilly 476 days ago Alternate ISBN found March 23, 2006 by snsnsnsn
Book Properties
ISBN: 0471370320
Title: Burger’s Medicinal Chemistry and Drug Discovery, 6 Volume Set
Author: by Donald J. Abraham (Editor)
Publisher: Wiley-Interscience
Publication Date: 2003-03-07
Number Of Pages: 5568
Average Amazon Rating: 5.0

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Burger’s Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines (Volume 3)
by: Donald J. Abraham

Burger’s Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines (Volume 3)
By Donald J. Abraham

Publisher: Wiley-Interscience
Number Of Pages: 912
Publication Date: 2003-02-20
ISBN-10 / ASIN: 0471370290
ISBN-13 / EAN: 9780471370291

Product Description:

This is Volume 3: Cardiovascular Agents and Endocrines, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Endogenous Vasoactive Peptides, Iron Chelators and Therapeutic Uses, and Fundamentals of Steroid Chemistry and Biochemistry.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.

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Electrically Assisted Transdermal and Topical Drug Delivery
by: Ajay K Banga

Electrically Assisted Transdermal and Topical Drug Delivery
By Ajay K Banga

Publisher: CRC
Number Of Pages: 172
Publication Date: 1998-09
ISBN-10 / ASIN: 0748406875
ISBN-13 / EAN: 9780748406876

Product Description:

This volume provides coverage assisted transdermal and topical delivery by mechanisms of iontophoresis, electroosmosis and electroporation. Other topics discussed are human and clinical studies with iontophoresis, such As Delivery Of Peptides, Proteins And Oligonucleotides, And Other developments.

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Burger’s Medicinal Chemistry and Drug Discovery, Autocoids, Diagnostics, and Drugs from New Biology (Volume 4)
by: Donald J. Abraham

Burger’s Medicinal Chemistry and Drug Discovery, Autocoids, Diagnostics, and Drugs from New Biology (Volume 4)
By Donald J. Abraham

Publisher: Wiley-Interscience
Number Of Pages: 720
Publication Date: 2003-02-20
ISBN-10 / ASIN: 0471370304
ISBN-13 / EAN: 9780471370307

Product Description:

This is Volume 4: Autocoids, Diagnostics, and Drugs from New Biology, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Peptide and Protein Hormones, Peptide Neurotransmitters, and Therapeutic Agents, Vitamins and SNPs: Single Nucleotide Polymorphisms and Pharmacogenomics.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.

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Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy (Practical Spectroscopy)
by: Emil W. Ciurczak, III, James K. Drennen,
en

0824794532 9780824794538 9780585408088

By Emil W. Ciurczak, III, James K. Drennen,

Publisher: CRC
Number Of Pages: 208
Publication Date: 2002-02-08
Sales Rank: 1445594
ISBN / ASIN: 0824794532
EAN: 9780824794538
Binding: Hardcover
Manufacturer: CRC
Studio: CRC

This book discusses the theory, instrumentation, validation, and implementation of near-infrared spectroscopy for pharmaceutical and medical applications. It showcases a diverse range of contemporary methods for the production, screening, and analysis of new drug products and pharmaceuticals. Presents current approaches in near-infrared spectroscopy (NIR) to monitor and control multiple phases of the drug manufacturing process.

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Transporters as Targets for Drugs (Topics in Medicinal Chemistry)
by: Susan Napier, Matilda Bingham

Transporters as Targets for Drugs (Topics in Medicinal Chemistry)
By Susan Napier, Matilda Bingham

Publisher: Springer
Number Of Pages: 253
Publication Date: 2009-06-01
ISBN-10 / ASIN: 3540879110
ISBN-13 / EAN: 9783540879114

Product Description:

Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied ‘flavours’ of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field.

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Transporters as Targets for Drugs (Topics in Medicinal Chemistry)
by: Susan Napier, Matilda Bingham

Transporters as Targets for Drugs (Topics in Medicinal Chemistry)
By Susan Napier, Matilda Bingham

Publisher: Springer
Number Of Pages: 253
Publication Date: 2009-06-01
ISBN-10 / ASIN: 3540879110
ISBN-13 / EAN: 9783540879114

Product Description:

Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied ‘flavours’ of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field.

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AAPS PharmSciTech Journal ~ Volume 10, Number 1 / March, 2009 pp1-315
by: Springer

Article
Indinavir-Loaded pH-Sensitive Microparticles for Taste Masking: Toward Extemporaneous Pediatric Anti-HIV/AIDS Liquid Formulations with Improved Patient Compliance
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Article
Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation
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Article
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J. Sahoo, P. N. Murthy, S. Biswal and Manik
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27-33

Article
Radiosterilization of Fluoroquinolones and Cephalosporins: Assessment of Radiation Damage on Antibiotics by Changes in Optical Property and Colorimetric Parameters
Babita Singh, D. V. Parwate and S. K. Shukla
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34-43

Article
Downscaling Drug Nanosuspension Production: Processing Aspects and Physicochemical Characterization
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44-53

Article
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Article
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62-68

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69-76

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Shahrzad Missaghi, Kurt A. Fegely and Ali R. Rajabi-Siahboomi
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77-80

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Physicochemical Characterization of Efavirenz–Cyclodextrin Inclusion Complexes
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81-87

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88-97

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98-103

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104-112

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Crystal Morphology Engineering of Pharmaceutical Solids: Tabletting Performance Enhancement
Sabiruddin Mirza, Inna Miroshnyk, Jyrki Heinämäki, Osmo Antikainen, Jukka Rantanen, Pia Vuorela, Heikki Vuorela and Jouko Yliruusi
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113-119

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Physicomechanical Properties of Naproxen-Loaded Microparticles Prepared from Eudragit L100
M. Maghsoodi
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120-128

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Initial Characterization of Micafungin Pulmonary Delivery via Two Different Nebulizers and Multivariate Data Analysis of Aerosol Mass Distribution Profiles
Shuai Shi, Elizabeth S. Dodds Ashley, Barbara D. Alexander and Anthony J. Hickey
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129-137

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138-146

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147-157

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158-165

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Article
Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid
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199-210

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211-219

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Uracha Ruktanonchai, Piyawan Bejrapha, Usawadee Sakulkhu, Praneet Opanasopit, Nuntavan Bunyapraphatsara, Varaporn Junyaprasert and Satit Puttipipatkhachorn
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J. P. Mitchell, M. W. Nagel, V. Avvakoumova, H. MacKay and R. Ali
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243-251

Article
The Abbreviated Impactor Measurement (AIM) Concept: Part II—Influence of Evaporation of a Volatile Component—Evaluation with a “Droplet-Producing” Pressurized Metered Dose Inhaler (pMDI)-Based Formulation Containing Ethanol as Cosolvent
J. P. Mitchell, M. W. Nagel, V. Avvakoumova, H. MacKay and R. Ali
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252-257

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258-265

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266-269

Article
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Erina Pretorius and Patrick J. D. Bouic
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270-275

Article
Preformulation Study of the Inclusion Complex Irbesartan-β-Cyclodextrin
Rajashree Hirlekar and Vilasrao Kadam
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276-281

Article
Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist
Natalja Genina, Heikki Räikkönen, Jyrki Heinämäki, Osmo Antikainen, Simo Siiriä, Peep Veski and Jouko Yliruusi
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282-288

Article
Preparation and Evaluation of Miconazole Nitrate-Loaded Solid Lipid Nanoparticles for Topical Delivery
Mangesh R. Bhalekar, Varsha Pokharkar, Ashwini Madgulkar, Nilam Patil and Nilkanth Patil
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289-296

Article
Studies of the Crystallization of Amorphous Trehalose Using Simultaneous Gravimetric Vapor Sorption/Near IR (GVS/NIR) and “Modulated” GVS/NIR
Abigail Moran and Graham Buckton
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297-302

Article
Psychrometric Analysis of the Environmental Equivalency Factor for Aqueous Tablet Coating
John C. Strong
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303-309

Article
Development and In Vivo Floating Behavior of Verapamil HCl Intragastric Floating Tablets
Anand Patel, Moin Modasiya, Dushyant Shah and Vishnu Patel
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Freeze-Drying of Pharmaceuticals and Biopharmaceuticals: Principles and Practice
by: Felix Franks

Freeze-Drying of Pharmaceuticals and Biopharmaceuticals: Principles and Practice
By Felix Franks

Publisher: Royal Society of Chemistry
Number Of Pages: 136
Publication Date: 2007-04-04
ISBN-10 / ASIN: 0854042687
ISBN-13 / EAN: 9780854042685

Product Description:

This book describes the technology of freeze-drying with particular emphasis on the properties of the material to be processed, pre-freezing (formulation) and post-drying (stability and shelf life). Materials science principles of glasses, as applied to the study of dried, mainly protein-based biopharmaceuticals and analytical methods are also covered.

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Drug Discovery and Development for Alzheimer’s Disease (2000)
by: Howard M. Fillit MD, Alan W. O’Connell PhD

Drug Discovery and Development for Alzheimer’s Disease (2000)
By Howard M. Fillit MD, Alan W. O’Connell PhD

Publisher: Springer Publishing Company
Number Of Pages: 280
Publication Date: 2001-12-15
ISBN-10 / ASIN: 082611542X
ISBN-13 / EAN: 9780826115423

Product Description:

(Institute for the Study of Aging) First volume in a new annual series presents the latest findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors to the use of telephonic screening and MRIs. DNLM: Alzheimer Disease–diagnosis–Congresses.

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Carbohydrate-based Drug Discovery, 2 Vol Set
by: Chi-Huey Wong

Carbohydrate-based Drug Discovery
By Chi-Huey Wong

Publisher: Wiley-VCH
Number Of Pages: 980
Publication Date: 2003-11-14
ISBN-10 / ASIN: 3527306323
ISBN-13 / EAN: 9783527306329

Product Description:

This handbook presents the latest knowledge on carbohydrate chemistry and biochemistry so as to exploit the full potential of this diverse compound class for the development of novel active substances. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following:

Chemical synthesis of carbohydrates
Carbohydrate biosynthesis and metabolism
Carbohydrate analysis
Cellular functions of carbohydrates
Development of carbohydrate-based drugs
A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world’s leading carbohydrate chemists.

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Technetium: Chemistry and Radiopharmaceutical Applications
by: Klaus Schwochau

Technetium: Chemistry and Radiopharmaceutical Applications
By Klaus Schwochau

Publisher: Wiley-VCH
Number Of Pages: 446
Publication Date: 2000-05-15
ISBN-10 / ASIN: 3527294961
ISBN-13 / EAN: 9783527294961

Product Description:

This unique handbook provides a comprehensive survey of the present status of Technetium chemistry and its radiopharmaceutical applications. All Technetium aspects such as
· natural and artificial occurence in the environment,
· isotopes and isomers,
· analytical chemistry and electrochemistry,
· thermodynamic data, stability and reactivity,
· intermetallic and binary compounds, and predominantly
· complex chemistry, and
· radiopharmacy
are presented in an clear and precise manner. This outstanding presentation allows both experts and non-experts a quick access to the subject. Therefore this handbook is an indispensable reference for researchers at universities and research centers, in the nuclear medicine and radiopharmaceutical industries as well as consultants in government and environmental agencies.

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NMR Spectroscopy in Pharmaceutical Analysis
by: Iwona Wawer, Bernd Diehl, Ulrike Holzgrabe
en

0444531734 9780444531735 9780080558196

NMR Spectroscopy in Pharmaceutical Analysis
By Iwona Wawer, Bernd Diehl, Ulrike Holzgrabe

Publisher: Elsevier Science
Number Of Pages: 528
Publication Date: 2008-10-10
ISBN-10 / ASIN: 0444531734
ISBN-13 / EAN: 9780444531735
Binding: Hardcover

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized.
Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis.
Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.

combines theory, techniques, and concrete applicationsall of which closely resemble the laboratory experience
considers international pharmacopoeias, addressing the concern for licensing
features the work of academics and researchers, appealing to a broad readership

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Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition
by: G.O. Evans

Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition
By G.O. Evans

Publisher: CRC
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Assembling information widely dispersed throughout the literature, the second edition of this work focuses on information of relevance to experimental toxicology as separate from human medicine. It presents background information on the selection and application of biochemical tests in safety assessment studies. In addition to chapters which discuss the assessment of toxicity in specific organs, such as the liver, kidney and thyroid, the book also covers pre-analytical variables, regulatory requirements, and statistical approaches, while highlighting some of the major differences between humans and various laboratory animals.

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Handbook of Radiopharmaceuticals
by: Michael J. Welch, Carol S. Redvanly (Editors)
en

0471495603 9780471495604 9780470851937

By Michael J. Welch, Carol S. Redvanly (Editors)

Publisher: Wiley
Number Of Pages: 500
Publication Date: 2002-06-15
Sales Rank: 162509
ISBN / ASIN: 0471495603
EAN: 9780471495604
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A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field.
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The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 200er year, and many drug companies are utilising PET and other forms of
radiopharmaceutical imaging to evaluate products.

Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations
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Handbook of Radiopharmaceuticals
by: Michael J. Welch, Carol S. Redvanly (Editors)
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0471495603 9780471495604 9780470851937

By Michael J. Welch, Carol S. Redvanly (Editors)

Publisher: Wiley
Number Of Pages: 500
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Sales Rank: 162509
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EAN: 9780471495604
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A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field.
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The HIV-1 envelope glycoproteins: folding, function and vaccin design
by: Rogier W. Sanders

The HIV-1 envelope glycoproteins: folding, function and vaccin design
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The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and are therefore major targets for vaccine design. The first part of this thesis describes research aimed at understanding the folding and function of the HIV-1 envelope glycoproteins and their properties underlying the effective viral immune evasion. The second part of the thesis describes the design of modifications of the envelope glycoproteins that should improve their properties as vaccine antigens.

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The Discovery, Use and Impact of Platinum Salts as Chemotherapy Agents for Cancer (Wellcome Witnesses to Twentieth Century Medicine Vol 30)
by: D, A Christie, E, M Tansey

The Discovery, Use and Impact of Platinum Salts as Chemotherapy Agents for Cancer (Wellcome Witnesses to Twentieth Century Medicine Vol 30)
Edited by D.A. Christie and E.M. Tansey. Introduction by Matti Aapro

Product Details

* ISBN: 0854841121
* ISBN-13: 9780854841127
* Format: Paperback, 148pp
* Publisher: Wellcome Institute for the History of Medicine
* Pub. Date: October 2007
* Series: Wellcome Witnesses to Twentieth Century Medicine
* Vol: 30

Proposed by Dr Mark Walport (Wellcome Trust) this Seminar examined the discovery, use and impact of platinum salts as chemotherapy agents for cancer. Organized with the assistance of Professor Paul Andrews (St George’s Hospital Medical School) and Dr Tony Woods (Wellcome Trust) and chaired by Professor Sir Kenneth Calman (Durham) the Seminar discussed the serendipitous emergence of platinum salts as widely used anticancer agents from a chance observation in a microbiology laboratory; through their use especially for the treatment of previously untreatable solid tumours such as those of the testes and ovary; and their significance in the development of antiemetic agents for chemotherapy patients. Participants included chemists, oncologists, and academic and industrial pharmacologists who devised, in particular, the 5HT3 receptor antagonists.

Participants included: Professor Kenneth Bagshawe, Dr Penelope Brock, Professor Hilary Calvert, Professor David Grahame-Smith, Professor Richard Gralla, Professor Kenneth Harrap, Dr James Hoeschele, Professor Ian Judson, Mr Wesley Miner, Professor Robert Naylor, Mrs Brenda Reynolds, Dr John Rudd, Dr Gareth Sanger, Dr David Tattersall, Professor Andrew Thomson, Professor Robert Williams and Dr Eve Wiltshaw.

Contents
Cover
Title Page
Copyright Page
Contents
Illustrations And Credits
Abbreviations
Acknowledgements
History Of Twentieth Century Medicine Witness Seminars,
Witness Seminars:
Published Meetings
Introduction
Transcripts
Participants
Appendix 1 In Praise of Methotrexateby Professor Sir Kenneth Calman
Appendix 2 Structures of some 5HT receptor antagonists
Appendix 3 Components of the emetic reflex
References
Biographical Notes
Glossary
Index: Subject
Index Names
Key to cover photographs

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Clinical Pharmacology in the UK, c.1950-2000: Influences and institutions (Wellcome Witnesses to Twentieth Century Medicine Vol 33)
by: L A Reynolds, E M Tansey (Editors)

Clinical Pharmacology in the UK, c.1950-2000: Influences and institutions (Wellcome Witnesses to Twentieth Century Medicine Vol 33)
Edited by L.A Reynolds and E.M. Tansey. Introduction by Mark Walport.

Product Details

* ISBN: 0854841172
* ISBN-13: 9780854841172
* Format: Paperback, 168pp
* Publisher: WT Centre for the History of Medicine at UCL
* Pub. Date: November 2008
* Series: Wellcome Witnesses to Twentieth Century Medicine
* Vol: 33

The history of clinical pharmacology in the UK over the last half of the twentieth century is largely untold. Many important new drugs were developed and brought to market in the 1950s and 1960s ensuring the need for more systematic knowledge of drug effects in humans and also providing new career opportunities in teaching, research and practice. The 30th anniversary of the British Journal of Clinical Pharmacology in 2004 and the 75th anniversary of the British Pharmacological Society in 2006 had prompted reflections from practicing clinical pharmacologists. It was timely, therefore, to bring together clinical pharmacologists and others who have shaped the discipline, to promote historical analysis and debate. Chaired by Professor Rod Flower, the meeting considered such questions as: What was/is clinical pharmacology? Which were the main centres of influence? Who and what were the main drivers? Who became clinical pharmacologists and why? What was the significance of specialized societies, meetings and journals?

Participants: Dr Stuart Anderson, Dr Jeffrey Aronson, Professor David Barnett, Dr Linda Beeley, Professor Sir James Black, Professor Morris Brown, Professor Mark Caulfield, Sir Iain Chalmers, Professor Donald Davies, Professor Robin Ferner, Dr Arthur Fowle, Professor Sir Charles George, Professor David Gordon, Professor David Grahame-Smith, Dr Andrew Herxheimer, Dr Kenneth Hunter, Professor Trevor Jones, Professor Desmond Laurence, Professor Denis McDevitt, Professor Walter Nimmo, Professor Michael Orme, Dr Anthony Peck, Professor Laurie Prescott, Professor Brian Prichard, Professor John Reid, Professor James Ritter, Professor Philip Routledge, Professor TilliTansey, Professor Geoffrey Tucker, Professor Patrick Vallance, Professor Duncan Vere, Professor Owen Wade, Professor David Webb and Professor Frank Woods.

Contents
Cover
Clinical Pharmacology in the UK, c.1950-2000: Influences and institutions
Title Page
Copyright Page
Contents
Illustrations And Credits
Witness Seminars:
Acknowledgements
History Of Twentieth Century Medicine Witness Seminars,
Published Meetings
Introduction
Clinical Pharmacology in the UK, c.1950-2000: Influences and institutions Transcripts
Participants
Appendix 1
References
Biographical Notes
Glossary
Index Subject
Index: Names
Key To Cover Photographs

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Clinical Pharmacology in the UK, c. 1950-2000: Industry and regulation (Wellcome Witnesses to Twentieth Century Medicine Vol 34)
by: L A Reynolds, E M Tansey (Editors)

Clinical Pharmacology in the UK, c. 1950-2000: Industry and regulation (Wellcome Witnesses to Twentieth Century Medicine Vol 34)
Edited by L.A Reynolds and E.M. Tansey. Introduction by Parveen Kumar.

Product Details
* ISBN: 0854841180
* ISBN-13: 9780854841189
* Format: Paperback, 148pp
* Publisher: WT Centre for the History of Medicine at UCL
* Pub. Date: December 2008
* Series: Wellcome Witnesses to Twentieth Century Medicine
* Vol: 34

Clinical pharmacology in the UK in the 1950s and 1960s was an exciting profession. Many important new drugs were developed and brought to market and a more systematic knowledge of drug effects in humans was needed, as well as ensuring the safety and efficacy of new and existing drugs, especially following the unexpected problems arising from the use of thalidomide. This Witness Seminar followed an earlier meeting on the history of the general development of clinical pharmacology and focuses on the development of clinical pharmacology in pharmaceutical companies and drug regulation. Professor Rod Flower chaired the meeting of clinical pharmacologists and others who shaped the discipline, which discussed the main centres of influence; the attraction to clinical pharmacologists of working in industry; whether the decline in the number of academic clinical pharmacologists was paralleled in drug companies; what drove drug regulation; and the relationships between companies and regulatory authorities.

Participants included Dr Jeffrey Aronson, Professor Nigel Baber, Sir Alasdair Breckenridge, Sir Iain Chalmers, Professor Joe Collier, Professor Donald Davies, Dr Peter Fletcher, Dr Arthur Fowle, Professor Sir Charles George, Professor David Grahame-Smith, Professor John Griffin, Dr Andrew Herxheimer, Professor Ray Hill, Dr Peter Lewis, Dr Tim Mant, Professor Denis McDevitt, Professor Michael Orme, Dr Anthony Peck, Professor Brian Prichard, Professor Sir Michael Rawlins, Professor John Reid, Professor Philip Routledge, Dr Julian Shelley, Dr Robert Smith, Professor Cameron Swift, Professor Tilli Tansey, Dr Duncan Vere, and the late Professor Owen Wade.

Contents
Cover
Clinical Pharmacology in the UK, C. 1950-2000
Title Page
Copyright Page
Contents
Illustrations And Credits
Abbreviations
Witness Seminars:
Acknowledgements
History Of Twentieth Century Medicine Witness Seminars,
Published Meetings
Introduction
Clinical Pharmacology in the UK, C. 1950-2000 Transcripts
Participants
References
Biographical Notes
Glossary
Index Subject
Index: Names
Key To Cover Photographs

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Clinical Pharmacology in the UK, c. 1950-2000: Industry and regulation (Wellcome Witnesses to Twentieth Century Medicine Vol 34)
by: L A Reynolds, E M Tansey (Editors)

Clinical Pharmacology in the UK, c. 1950-2000: Industry and regulation (Wellcome Witnesses to Twentieth Century Medicine Vol 34)
Edited by L.A Reynolds and E.M. Tansey. Introduction by Parveen Kumar.

Product Details
* ISBN: 0854841180
* ISBN-13: 9780854841189
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* Pub. Date: December 2008
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Clinical pharmacology in the UK in the 1950s and 1960s was an exciting profession. Many important new drugs were developed and brought to market and a more systematic knowledge of drug effects in humans was needed, as well as ensuring the safety and efficacy of new and existing drugs, especially following the unexpected problems arising from the use of thalidomide. This Witness Seminar followed an earlier meeting on the history of the general development of clinical pharmacology and focuses on the development of clinical pharmacology in pharmaceutical companies and drug regulation. Professor Rod Flower chaired the meeting of clinical pharmacologists and others who shaped the discipline, which discussed the main centres of influence; the attraction to clinical pharmacologists of working in industry; whether the decline in the number of academic clinical pharmacologists was paralleled in drug companies; what drove drug regulation; and the relationships between companies and regulatory authorities.

Participants included Dr Jeffrey Aronson, Professor Nigel Baber, Sir Alasdair Breckenridge, Sir Iain Chalmers, Professor Joe Collier, Professor Donald Davies, Dr Peter Fletcher, Dr Arthur Fowle, Professor Sir Charles George, Professor David Grahame-Smith, Professor John Griffin, Dr Andrew Herxheimer, Professor Ray Hill, Dr Peter Lewis, Dr Tim Mant, Professor Denis McDevitt, Professor Michael Orme, Dr Anthony Peck, Professor Brian Prichard, Professor Sir Michael Rawlins, Professor John Reid, Professor Philip Routledge, Dr Julian Shelley, Dr Robert Smith, Professor Cameron Swift, Professor Tilli Tansey, Dr Duncan Vere, and the late Professor Owen Wade.

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Cover
Clinical Pharmacology in the UK, C. 1950-2000
Title Page
Copyright Page
Contents
Illustrations And Credits
Abbreviations
Witness Seminars:
Acknowledgements
History Of Twentieth Century Medicine Witness Seminars,
Published Meetings
Introduction
Clinical Pharmacology in the UK, C. 1950-2000 Transcripts
Participants
References
Biographical Notes
Glossary
Index Subject
Index: Names
Key To Cover Photographs

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Narcotic Drugs/Stupefiants/Estupefacientes: Estimated World Requirements for 2007/Evaluations des besoins du monde pour 2007/Previsiones de las necesidades mundiales para 2007
by: United Nations Publications

Narcotic Drugs/Stupefiants/Estupefacientes: Estimated World Requirements for 2007/Evaluations des besoins du monde pour 2007/Previsiones de las necesidades mundiales para 2007 : Statistics for 2
By United Nations Publications

Publisher: United Nations Publications
Number Of Pages: 350
Publication Date: 2007-04
ISBN-10 / ASIN: 9210481135
ISBN-13 / EAN: 9789210481137

Notes:
Part one provides general information for users of the present technical report on narcotic drugs. It consists of a section
entitled “Introduction”, a section entitled “Remarks on the statistical tables” and three indexes:
(a) A French-English index of names of countries and non-metropolitan territories;
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(c) An English-French-Spanish index of names of narcotic drugs.
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in English alphabetical order.
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stupéfiants. Elle comprend une section intitulée “Introduction”, une section intitulée “Observations sur les tableaux
statistiques” et trois index:
a) Un index français-anglais des noms de pays et de territoires non métropolitains;
b) Un index espagnol-anglais des noms de pays et de territoires non métropolitains;
c) Un index des noms de stupéfiants en anglais, espagnol et français.
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ayant été apportées à la structure et au contenu du présent rapport.
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statistiques qui figurent dans les deuxième, troisième, quatrième et cinquième parties de la publication.
Les index facilitent les références, étant donné que, dans les tableaux, les pays, les territoires non métropolitains et les
stupéfiants sont indiqués dans l’ordre alphabétique anglais.
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a) Un índice francés-inglés de los nombres de los países y los territorios no metropolitanos;
b) Un índice español-inglés de los nombres de los países y los territorios no metropolitanos;
c) Un índice inglés-francés-español de los nombres de los estupefacientes.
En la “Introducción” se explican la finalidad del informe técnico y las principales modificaciones introducidas en la
estructura y el contenido del informe preparado este año.
La sección titulada “Observaciones sobre los cuadros estadísticos” contiene aclaraciones de carácter general sobre los
cuadros estadísticos que figuran en las partes segunda, tercera, cuarta y quinta de la publicación.
Los índices facilitan la consulta, ya que los países, los territorios y los estupefacientes se enumeran en los cuadros
siguiendo el orden alfabético inglés.
Se utiliza papel de distinto color para diferenciar las cinco partes de la publicación.
2

CONTENTS
Page
Part one. General information. . . . . . . . . . . . . . . . . . . . . . . 1
Introduction… . . . . . . . . . . . . . . . . 3
Remarks on the statistical tables..3
French-English index of names of countries and non-metropolitan territories.. . . . . . . . 9
Spanish-English index of names of countries and non-metropolitan territories.. . . . . . . 13
English-French-Spanish index of names of narcotic drugs. . . 17
Part two. Status of adherence to international conventions on narcotic drugs and receipt of
statistics (2005) and estimates (2007). . . . . 19
Notes.. . 20
Table.. . 21
Part three. Estimated requirements of narcotic drugs.. . . . . . . . . . . . . . . . . . . . 31
Notes.. . 32
Table A. Estimated world requirements of narcotic drugs for 2007.. . . . . . . . . . . . . 35
Table B. World totals of estimates, 2002-2007. . . . . . . . . . 64
Part four. Statistical information on narcotic drugs. . . 67
Notes.. . 69
Comments on the reported statistics on narcotic drugs. . . . . . 71
Supply of opiate raw materials and demand for opiates for medical and scientific purposes . . . . . . . . . . . . . . . . . . 92
Tables of reported statistics… . . . 159
Table I. Cultivation of Papaver somniferum for the production of opium, 2001-2007 . . . . . . . . . . . . . . . . . 171
Table II. Cultivation of Papaver somniferum for purposes other than the production of opium, 2001-2007 172
Table III. Extraction of alkaloids from opium, 2001-2005.. . . . . . . . . . . . . . . . . . 176
Table IV. Extraction of morphine from poppy straw (M), 2001-2005.. . . . . . . . 178
Table V. Extraction of thebaine from poppy straw (M and T), 2001-2005.. . . . 182
Table VI. Conversion of morphine, 2001-2005. . . . . . . 184
Table VII. Conversion of thebaine, 2001-2005. . . . . . . . 189
Table VIII. Manufacture of alkaloids contained in concentrate of poppy straw, 2001-2005 . . . . . . . . . . . . . . . 192
Table IX. Manufacture of the principal narcotic drugs, 2001-2005.. . . . . . . . . . . 194
Table X. Manufacture of other narcotic drugs. . . . . . . 200
1. Derivatives of opium alkaloids, 2001-2005. . . . . . . 200
2. Synthetic opioids, 2001-2005. . . . . . . . . . . . . . . . . . 200
Table XI. Production, utilization, imports and exports of coca leaf and manufacture of cocaine, 2001-2005 . . 201
Table XII. Consumption of the principal narcotic drugs, 2001-2005.. . . . . . . . . . 204
Table XIII. Consumption of other narcotic drugs, 2001-2005… . . . . . . . . . . . . . . . 230
1. Fentanyl, principal fentanyl analogues and piritramide, 2001-2005.. . . . . . . . 230
2. Other derivatives of opium alkaloids, 2001-2005. . 249
3. Other synthetic opioids, 2001-2005. . . . . . . . . . . . . 249
Table XIV. Levels of consumption of narcotic drugs. . . 250
1. Average consumption of narcotic drugs, in defined daily doses for statistical purposes per million
inhabitants per day, excluding preparations listed in Schedule III, 2003-2005 . . . . . . . . . . . . . . . . . . . . . . 250
2. Global average levels of utilization of narcotic drugs for the manufacture of preparations listed in
Schedule III, in defined daily doses for statistical purposes per million inhabitants per day, 2001-2005 259
Table XV. Total stocks of narcotic drugs, 2001-2005. . 260
Table XVI. World trade… . . 262
1. Exports of opiate raw materials, 2003-2005. . . . . . 262
2. Imports of opiate raw materials, 2003-2005. . . . . . 264
3. Exports of the principal narcotic drugs, 2003-2005.. . . . . . . . . . . . . . . . . . . . 266
4. Imports of the principal narcotic drugs, 2003-2005.. . . . . . . . . . . . . . . . . . . . 272
Table XVII. Seizures of selected narcotic drugs, 2005. . . 289
Part five. Comparative statement of estimates and statistics for 2005.. . . . . 295
Notes.. . 296
Table.. . 298

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Receptor - Based Drug Design (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)
by: Paul Leff
en

0824701623 9780824701628 9780585157900

Receptor - Based Drug Design (Drugs and the Pharmaceutical Sciences)
By Paul Leff

Publisher: CRC
Number Of Pages: 400
Publication Date: 1998-04-01
ISBN-10 / ASIN: 0824701623
ISBN-13 / EAN: 9780824701628

Product Description:

Employs a wide range of examples from G protein-coupled receptors and ligand-gated ion channels. Illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors.

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Advanced Practical Medicinal Chemistry
by: Ashutosh Kar

Advanced Practical Medicinal Chemistry
By Ashutosh Kar

Publisher: New Age International (P) Ltd.
Number Of Pages: 332
Publication Date: 2004
ISBN-10 / ASIN: 8122415393
ISBN-13 / EAN: 9788122415391
Advanced Practical Medicinal Chemistry
Kar, Ashutosh , Professor and Head of Pharmacy Shri R.N.S. College of Pharmacy Gormi, Bhind (M.P.)
ISBN : 978-81-224-1539-1
Publication Year : 2004
Edition : 1st
Reprint : Jan, 2009
Pages : 330
Price : $ 15
Binding : Paperback

About the Book:
The present compendium on Advanced Practical Medicinal Chemistry is designed specifically to serve as a text-cum-reference book not only intended for the advanced undergraduate and graduate students of Pharmacy specializing in pharmaceutical chemistry but also for the bulk-drug industrial researchers and academics who work intimately with medicinal compounds. It mainly comprises of four comprehensive chapters. First chapter is entirely devoted to Safety in Chemical Laboratory, which is an absolute must for each medicinal chemist. Second chapter is on Drug Synthesis and concentrates on three vital aspects, namely : conceptualization of a synthesis, reaction variants, and stereochemistry. Third chapter exclusively deals with Performing the Reactions and entails the wide range of latest laboratory techniques used in a good chemical laboratory to facilitate synthesis of drugs.

Fourth chapter is particularly focused and earmarked to Synthesis of Medicinal Compounds, and essentially include various cardinal aspects, such as :types of chemical reactions, organic name reactions (ONRs), and selected medicinal compounds. A galaxy of eighty carefully chosen medicinal compounds have been presented in an original unique style comprising of: chemical structure, synonym (s)/chemical name(s) theory chemicals required procedure precautions recrystallization theoretical yield/practical yield physical parameters uses, and questions for viva-voce.

It is hoped that Advanced Practical Medicinal Chemistry would certainly help to bridge existing gap and fill up the long needed vacuum in the synthesis of drugs in pharmaceutical chemistry departments, academics and bulk-drug industries, and may provide the basis for meaningful productive group discussions of synthetic problems on a broader perspective.

About the Author:
Ashutosh Kar is a well-known Professor of Pharmaceutical Chemistry, presently, teaching at Shri RNS College of Pharmacy, Gormi, Bhind (M.P.). He has to his credit twenty-seven years teaching experience at undergraduate and graduate levels both in Indian Universities and abroad. He has published more than twenty research papers based on pharmacological studies on natural and synthetic drugs in international and national scientific journals. He has taught at School of Pharmacy, Addis Ababa University, Addis Ababa (Ethiopia) (2002-2005); Guru Jhambheshwar University, Hisar (India) (1999-2002); Al-Arab Medical University, Benghazi, (Libya) (1997-1998); College of Pharmacy (University of Delhi), Delhi (India) (1990-1994); Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka (Nigeria) (1976-1987).

Professor Kar has an excellent track record in academic institutions of high repute, and actively engaged in teaching, research, administration, and service to his profession. He has to his credit more than fifty research papers, and guided several PG/Ph.D., students in Nigeria, India, and Ethiopia. He has bagged the University Gold Medal in B. Pharm., and M. Pharm., examinations from the University of Saugar, Saugor (M.P.) and completed his Ph.D. He is the life member of several national professional bodies like: APTI, IPGA, and ISTE.

Professor Kar has been conferred with “Lifetime Achievement Award, 2008“, by the Indian Association of Pharmaceutical Scientists and Technologists, Kolkata for his immerse contribution in the Indian Pharmacy Profession on the 19th January, 2008. Professor Kar has completed nine textbooks, namely: Medicinal Chemistry (4th/edn: 2006); Pharmaceutical Drug Analysis (2nd/edn: 2005); Pharmacognosy and Pharmacobiotechnology (2nd/edn: 2006); Advanced Practical Medicinal Chemistry (2004); Pharmaceutical Biotechnology [2005 (HB) & 2006 (PB)]; Pharmaceutical Microbiology (2006); Pharmaceutical Pharmacology (2009); Pharmaceutical Analysis Vol. I (2007); and Pharmaceutical Analysis Vol. II (2009) Besides, Professor Kar`s ten year stint of industrial experience in Public Limited Companies as: General Manager (R&D), Production Manager (Food), and Research and Development Officer has inculcated in him a tremendous in-built stimulus of sophisticated research academic laboratories both in the African Continent and top-notch Indian Universities.

Contents:
Safety in a Chemistry LaboratoryDrug SynthesisPerforming the ReactionsSynthesis of Medicinal CompoundsIndex.

Audience: Chemistry,Bestsellers,Pharmacy

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Handbook for Synthesizing Qualitative Research
by: Margarete Sandelowski PhD RN FAAN, Julie Barroso PhD ANP APRN

Handbook for Synthesizing Qualitative Research
By Margarete Sandelowski PhD RN FAAN, Julie Barroso PhD ANP APRN

Publisher: Springer Publishing Company
Number Of Pages: 312
Publication Date: 2006-07-24
ISBN-10 / ASIN: 0826156940
ISBN-13 / EAN: 9780826156945

Product Description:

Written for graduate-level students and faculty in health care science disciplines, this handbook will help integrate the findings in reports of primary qualitative studies as well as extrapolate the methods and techniques used to create a qualitative research synthesis. Using reports of studies in two domains of research and across behavior, social science, and practice disciplines, this handbook helps: * Locate qualitative research synthesis in qualitative research, research synthesis, research utilization, and evidence-based practice * Locate the qualitative research synthesis enterprise in reading and writing practices * Differentiate qualitative research synthesis from other forms of inquiry * Formulate significant research problems and purposes for a qualitative research synthesis study * Design credible qualitative research synthesis studies that fit available resources * Conduct comprehensive searches for primary qualitative research reports in a target domain of inquiry * Conduct judicious appraisals of these qualitative research reports * Compare and classify findings across qualitative research reports * Select methodological approaches appropriate to the content and form of the qualitative research findings * Use qualitative metasummary and metasynthesis techniques to integrate qualitative research findings * Optimize the validity of qualitative research synthesis studies * Present the results of qualitative research synthesis studies in effective, audience-appropriate ways

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Formulation and Analytical Development for Low-Dose Oral Drug Products
by: Jack Zheng

Formulation and Analytical Development for Low-Dose Oral Drug Products
By Jack Zheng

Publisher: Wiley
Number Of Pages: 461
Publication Date: 2009-02-09
ISBN-10 / ASIN: 0470056096
ISBN-13 / EAN: 9780470056097

Product Description:

There are unique challenges in the formulation, manufacture, analytical chemistry, and regulatory requirements of low-dose drugs. This book provides an overview of this specialized field and combines formulation, analytical, and regulatory aspects of low-dose development into a single reference book. It describes analytical methodologies like dissolution testing, solid state NMR, Raman microscopy, and LC-MS and presents manufacturing techniques such as granulation, compaction, and compression. Complete with case studies and a discussion of regulatory requirements, this is a core reference for pharmaceutical scientists, regulators, and graduate students.

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The Khat Controversy: Stimulating the Debate on Drugs (Cultures of Consumption)
by: David A. Anderson, Susan Beckerleg, Degol Hailu, Axel Klein
en | Berg Publishers

1845202503 9781845202507 1845202511 9781845202514

The Khat Controversy: Stimulating the Debate on Drugs (Cultures of Consumption)
By David A. Anderson, Susan Beckerleg, Degol Hailu, Axel Klein

Publisher: Berg Publishers
Number Of Pages: 256
Publication Date: 2007-08-21
ISBN-10 / ASIN: 1845202503
ISBN-13 / EAN: 9781845202507

Product Description:

Khat is a natural substance that, in the Middle East, is as ubiquitous as coffee in the West. It is hugely popular in some African and Arab populations. But critics contend that it is a seriously addictive stimulant that damages the cardiovascular system. In a groundbreaking study, the authors go behind the veil of the drug, questioning its availability and its affect on its Red Sea producers. Interwoven with case studies from Djibouti to Rome, The Khat Controversy goes deeper to explore contemporary issues relating to globalization, ethnicity and culture. The first study of this contested drug, Khat provides a concise introduction to the issues surrounding Khat usage and suggests how policymakers should address them.

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by: United Nations

Narcotic Drugs: Estimated World Requirements for 2006 (Statistics for 2004)
By United Nations

Publisher: United Nations Publications
Number Of Pages: 360
Publication Date: 2006-04-07
ISBN-10 / ASIN: 9210481089
ISBN-13 / EAN: 9789210481083

Product Description:

This publication provides analysis of recent trends and statistics for estimated requirements and actual movements of narcotic drugs. Data is provided for specific groups of drugs and countries. This trilingual publication is in English, French and Spanish.

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Towards Drugs of the Future: Key Issues in Lead Finding and Lead Optimization - Volume 9 Solvay Pharmaceuticals Conferences
by: C.G. Kruse

Towards Drugs of the Future: Key Issues in Lead Finding and Lead Optimization - Volume 9 Solvay Pharmaceuticals Conferences
By C.G. Kruse

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Number Of Pages: 130
Publication Date: 2009-01-15
ISBN-10 / ASIN: 1586039490
ISBN-13 / EAN: 9781586039493

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The scope of this book is that the pharmaceutical industry must change the way it operates. The editors of this book feel that the current business model is economically unsustainable and incapable to meet expectations of modern society. The number of novel medications in the global industry pipeline is insufficient to suffice demand of the markets, the financial performance of several companies is declining, sales and marketing costs are rising, regulatory constraints are increasingly challenging and overall reputation of industry is tarnishing. Unmet medical needs must be better addressed and tangible benefits need to be exposed in order to be rewarded by healthcare payers. In addition, the focus is shifting from simple treatment of the ill to preventative measures and health management. This volume addresses newest development in synthetic and medicinal chemistry with the emphasis on global challenges. One of the goals is to ensure that new chemistry develops novel technologies in which system biology approach or target approach is computer simulated, testing is performed in silico on rat or human digital models and synthesis of molecules is restricted to intelligent synthesis of treatments based on simulations. Implementation of such new technologies requires the pharmaceutical industry to rethink and adopt the current business model in order to contribute value to the healthcare systems of the future.

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