AAPS PharmSciTech Journal ~ Volume 10, Number 2 June, 2009 pp317-702
by: AAPS
en | American Association of Pharmaceutical Scientists

47 ArticlesFirst | 1-10 | 11-20 | 21-30 | 31-40 | 41-47 | Next
Glycosylation of Aromatic Amines I: Characterization of Reaction Products and Kinetic Scheme
Madhushree Y. Gokhale, William R. Kearney and Lee E. Kirsch
PDF (315.6 KB)HTML
317-328

Physicochemical Properties of Solid Dispersions of Gliclazide in Polyvinylpyrrolidone K90
S. Biswal, J. Sahoo and P. N. Murthy
PDF (163.9 KB)HTML
329-334

Agglomerates Containing Pantoprazole Microparticles: Modulating the Drug Release
Renata P. Raffin, Paolo Colombo, Fabio Sonvico, Alessandra Rossi, Denise S. Jornada, Adriana R. Pohlmann and Silvia S. Guterres
PDF (563.2 KB)HTML
335-345

Polymer–Magnesium Aluminum Silicate Composite Dispersions for Improved Physical Stability of Acetaminophen Suspensions
Thaned Pongjanyakul and Satit Puttipipatkhachorn
PDF (390.5 KB)HTML
346-354

Mechanistic Evaluation of the Effect of Sintering on Compritol® 888 ATO Matrices
Monica Rao, Anuradha Ranpise, Sameer Borate and Kaushik Thanki
PDF (286.3 KB)HTML
355-360

Intranasal Microemulsion of Sildenafil Citrate: In Vitro Evaluation and In Vivo Pharmacokinetic Study in Rabbits
Ahmed H. Elshafeey, Ehab R. Bendas and Osama H. Mohamed
PDF (193.4 KB)HTML
361-367

Characterization and Stability of Emulsion Gels Based on Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer
Giulia Bonacucina, Marco Cespi and Giovanni F. Palmieri
PDF (336.0 KB)HTML
368-375

The Study on the Entrapment Efficiency and In Vitro Release of Puerarin Submicron Emulsion
Peng-Fei Yue, Xiu-Yun Lu, Zeng-Zhu Zhang, Hai-Long Yuan, Wei-Feng Zhu, Qin Zheng and Ming Yang
PDF (268.7 KB)HTML
376-383

Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability
Santo Scalia and Matteo Mezzena
PDF (219.9 KB)HTML
384-390

Hesperidin Gastroresistant Microparticles by Spray-Drying: Preparation, Characterization, and Dissolution Profiles
Francesca Sansone, Alessandra Rossi, Pasquale Del Gaudio, Francesco De Simone, Rita Patrizia Aquino and Maria Rosaria Lauro
PDF (473.7 KB)HTML
391-40

Development of Microsponges for Topical Delivery of Mupirocin
Netal Amrutiya, Amrita Bajaj and Madhu Madan
PDF (210.6 KB)HTML
402-409

Intratumoral Delivery of Paclitaxel in Solid Tumor from Biodegradable Hyaluronan Nanoparticle Formulations
Abeer M. Al-Ghananeem, Ahmad H. Malkawi, Yahya M. Muammer, Justin M. Balko, Esther P. Black, Walid Mourad and Edward Romond
PDF (375.2 KB)HTML
410-417

Colon Specific Delivery of Indomethacin: Effect of Incorporating pH Sensitive Polymers in Xanthan Gum Matrix Bases
Laila F. A. Asghar, Chetan B. Chure and Sajeev Chandran
PDF (241.4 KB)HTML
418-429

Comparison of the Halving of Tablets Prepared with Eccentric and Rotary Tablet Presses
T. Sovány, P. Kása Jr. and K. Pintye-Hódi
PDF (288.2 KB)HTML
430-436

Development and Evaluation of Ethyl Cellulose-Based Transdermal Films of Furosemide for Improved In Vitro Skin Permeation
Dhaval P. Patel, Chitral Mallikarjuna Setty, Gaurav N. Mistry, Santnu L. Patel, Tarun J. Patel, Pritesh C. Mistry, Amar K. Rana, Pritesh K. Patel and Rishabh S. Mishra
PDF (143.3 KB)HTML
437-442

Formulation and Performance Characterization of Radio-Sterilized “Progestin-Only” Microparticles Intended for Contraception
Shivanand Puthli and Pradeep Vavia
PDF (226.7 KB)HTML
443-452

Anhydride Prodrug of Ibuprofen and Acrylic Polymers
Boaz Mizrahi and Abraham J. Domb
PDF (204.8 KB)HTML
453-458

Development and Evaluation of Sustained Release Gastroretentive Minimatrices for Effective Treatment of H. pylori Infection
Atul C. Badhan, Rajashree C. Mashru, Punit P. Shah, Arti R. Thakkar and Nitin B. Dobaria
PDF (294.9 KB)HTML
459-467

Influence of the Selected Antioxidants on the Stability of the Celsior Solution Used for Perfusion and Organ Preservation Purposes
Aneta Ostró偶ka-Cie艣lik, Barbara Doli艅ska and Florian Ryszka
PDF (162.8 KB)HTML
468-475

Microemulsion-Based Vaginal Gel of Clotrimazole: Formulation, In Vitro Evaluation, and Stability Studies
Yogeshwar G. Bachhav and Vandana B. Patravale
PDF (155.2 KB)HTML
476-481

SMEDDS of Glyburide: Formulation, In Vitro Evaluation, and Stability Studies
Yogeshwar G. Bachhav and Vandana B. Patravale
PDF (150.0 KB)HTML
482-487

Effect of Sugars, Surfactant, and Tangential Flow Filtration on the Freeze-Drying of Poly(lactic acid) Nanoparticles
Samuli Hirsjärvi, Leena Peltonen and Jouni Hirvonen
PDF (191.0 KB)HTML
488-494

Disintegration of Highly Soluble Immediate Release Tablets: A Surrogate for Dissolution
Abhay Gupta, Robert L. Hunt, Rakhi B. Shah, Vilayat A. Sayeed and Mansoor A. Khan
PDF (190.3 KB)HTML
495-499

Difference in the Lubrication Efficiency of Bovine and Vegetable-Derived Magnesium Stearate During Tabletting
Abhay Gupta, Mazen L. Hamad, Mobin Tawakkul, Vilayat A. Sayeed and Mansoor A. Khan
PDF (268.7 KB)HTML
500-504

Optimization of Hydrogels for Transdermal Delivery of Lisinopril by Box–Behnken Statistical Design
Ramesh Gannu, Vamshi Vishnu Yamsani, Shravan Kumar Yamsani, Chinna Reddy Palem and Madhusudan Rao Yamsani
PDF (407.0 KB)HTML
505-514

Extended Release Felodipine Self-Nanoemulsifying System
Pradeep R. Patil, Shailesh V. Biradar and Anant R. Paradkar
PDF (204.3 KB)HTML
515-523

Near-Infrared Analysis of Hydrogen-Bonding in Glass- and Rubber-State Amorphous Saccharide Solids
Ken-ichi Izutsu, Yukio Hiyama, Chikako Yomota and Toru Kawanishi
PDF (167.6 KB)HTML
524-529

Formulation and Evaluation of Bioadhesive Buccal Drug Delivery of Tizanidine Hydrochloride Tablets
Gazzi Shanker, Chegonda K. Kumar, Chandra Sekhara Rao Gonugunta, B. Vijaya Kumar and Prabhakar Reddy Veerareddy
PDF (255.7 KB)HTML
530-539

Development and Characterization of 99mTc-timolol Maleate for Evaluating Efficacy of In Situ Ocular Drug Delivery System
Himanshu Gupta, M. Aqil, R. K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal and Sanyog Jain
PDF (161.9 KB)HTML
540-546

Modulation and Optimization of Drug Release from Uncoated Low Density Porous Carrier Based Delivery System
Praveen Sher, Ganesh Ingavle, Surendra Ponrathnam, Pankaj Poddar and Atmaram P. Pawar
PDF (734.6 KB)HTML
547-558

Development of Novel Microemulsion-Based Topical Formulations of Acyclovir for the Treatment of Cutaneous Herpetic Infections
Shishu, Sunita Rajan and Kamalpreet
PDF (309.9 KB)HTML
559-565

Sugar End-Capped Poly-d,l-lactides as Excipients in Oral Sustained Release Tablets
Sirpa Vuorinen, Jyrki Heinämäki, Osmo Antikainen, Mohammed Lahcini, Timo Repo and Jouko Yliruusi
PDF (500.4 KB)HTML
566-573

Formulation Design and Optimization of Novel Taste Masked Mouth-Dissolving Tablets of Tramadol Having Adequate Mechanical Strength
Ashwini R. Madgulkar, Mangesh R. Bhalekar and Rahul R. Padalkar
PDF (192.0 KB)HTML
574-581

Freeze-Dry Microscopy: Impact of Nucleation Temperature and Excipient Concentration on Collapse Temperature Data
Eva Meister, Slobodan Šaši and Henning Gieseler
PDF (320.3 KB)HTML
582-588

Microemulsions Containing Medium-Chain Glycerides as Transdermal Delivery Systems for Hydrophilic and Hydrophobic Drugs
Jaclyn Hosmer, Rachel Reed, M. Vitória L.B. Bentley, Adwoa Nornoo and Luciana B. Lopes
PDF (250.4 KB)HTML
589-596

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems
Emilie Chevalier, Marylène Viana, Aymeric Artaud, Lisette Chomette, Samir Haddouchi, Gille Devidts and Dominique Chulia
PDF (403.9 KB)HTML
597-605

Preparation and Characterization of Co-Grinded Mixtures of Aceclofenac and Neusilin US2 for Dissolution Enhancement of Aceclofenac
Ambarish H. Vadher, Jolly R. Parikh, Rajesh H. Parikh and Ajay B. Solanki
PDF (322.6 KB)HTML
606-614

Investigations on the Physical Structure and the Mechanism of Drug Release from an Enteric Matrix Microspheres with a Near-Zero-Order Release Kinetics Using SEM and Quantitative FTIR
Wasfy M. Obeidat, Safwan M. Obeidat and Nizar M. Alzoubi
PDF (339.6 KB)HTML
615-623

Fabrication of Triple-Layer Matrix Tablets of Venlafaxine Hydrochloride Using Xanthan Gum
Mukesh C. Gohel and Shital H. Bariya
PDF (170.8 KB)HTML
624-630

Preparation and In Vitro Evaluation of Solid Dispersions of Total Flavones of Hippophae rhamnoides L.
Yan Xie, Guowen Li, Xiurong Yuan, Zhenzhen Cai and Rong Rong
PDF (325.7 KB)HTML
631-640

Preparation and Evaluation of Differently Sulfonated Styrene–Divinylbenzene Cross-linked Copolymer Cationic Exchange Resins as Novel Carriers for Drug Delivery
Prasert Akkaramongkolporn, Tanasait Ngawhirunpat and Praneet Opanasopit
PDF (334.2 KB)HTML
641-648

Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies
Farnaz Monajjemzadeh, Davoud Hassanzadeh, Hadi Valizadeh, Mohammad R. Siahi-Shadbad, Javid Shahbazi Mojarrad, Thomas Robertson and Michael S. Roberts
PDF (263.2 KB)HTML
649-659

Enhancement of Oral Bioavailability of Cilostazol by Forming its Inclusion Complexes
Samir G. Patel and Sadhana J. Rajput
PDF (258.8 KB)HTML
660-669

Chitosan–Chondroitin Sulfate Based Matrix Tablets for Colon Specific Delivery of Indomethacin
Jitendra R. Amrutkar and Surendra G. Gattani
PDF (259.5 KB)HTML
670-677

Effect of EDTA and Methionine on Preventing Loss of Viscosity of Cellulose-Based Topical Gel
Junyan A. Ji, Erika Ingham and John Y. Wang
PDF (175.4 KB)HTML
678-683

Fabrication of Modified Transport Fluconazole Transdermal Spray Containing Ethyl Cellulose and Eudragit® RS100 as Film Formers
Mukesh C. Gohel and Stavan A. Nagori
PDF (245.5 KB)HTML
684-691

Dental Mold: A Novel Formulation to Treat Common Dental Disorders
Soma Ghosh, Gopa Roy and Biswajit Mukherjee
PDF (336.3 KB)HTML
692-702

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Basic and Clinical Pharmacology, 11th Edition (LANGE Basic Science)
by: Bertram Katzung, Anthony Trevor, Susan Masters

Basic and Clinical Pharmacology, 11th Edition (LANGE Basic Science)
By Bertram Katzung, Anthony Trevor, Susan Masters

Publisher: McGraw-Hill Medical
Number Of Pages: 1200
Publication Date: 2009-07-31
ISBN-10 / ASIN: 0071604057
ISBN-13 / EAN: 9780071604055

Product Description:

The most trusted and up-to-date pharmacology text in medicine — completely redesigned to make the learning process even more interesting and efficient

Organized to reflect the syllabi in Pharmacology courses, Basic & Clinical Pharmacology covers all the important concepts students need to know about the science of pharmacology and its application to clinical practice. It is acknowledged worldwide as the field’s most current, authoritative, and comprehensive textbook. To be as clinically-relevant as possible, the book features a strong focus on the choice and use of drugs in patients and the monitoring of their effects.

Coverage that spans every important aspect of medical pharmacology:

Basic Principles
Autonomic Drugs
Cardiovascular-Renal Drugs
Drugs with Important Actions on Smooth Muscle
Drugs that Act in the Central Nervous System
Drugs Used to Treat Diseases of the Blood, Inflammation, and Gout
Endocrine Drugs
Chemotherapeutic Drugs
Toxicology
NEW to this edition:

Full-color presentation, including 300 illustrations
Case studies open many chapters
Summary tables at the end of most chapters
Descriptions of important newly released drugs, including new immunopharmacologic agents
Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters

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Dictionary for Clinical Trials
by: Simon Day
en | Wiley

047005817X 9780470058176 9780470319161

Dictionary for Clinical Trials
By Simon Day

Publisher: Wiley
Number Of Pages: 262
Publication Date: 2007-06-11
ISBN-10 / ASIN: 047005817X
ISBN-13 / EAN: 9780470058176

Product Description:

As a result of the expansion in the area of pharmaceutical medicine there is an ever-increasing need for educational resources. The Dictionary of Clinical Trials, Second Edition comprehensively explains the 3000 words and short phrases commonly used when designing, running, analysing and reporting clinical trials.

This book is a quick, pocket reference tool to understand the common and less well-used terms within the discipline of clinical trials, and provides an alternative to the textbooks available. Terms are heavily cross-referenced, which helps the reader to understand how terms fit into the broad picture of clinical trials.

Wide ranging, brief, pragmatic explanations of clinical trial terminology
Scope includes medical, statistical, epidemiological, ethical, regulatory and data management terminology
Thoroughly revised and expanded - increase of 280 terms from First Edition, reference to Cochrane included
From the reviews of the First Edition:

"This invaluable text explains the majority of clinical trial terms, in alphabetical order, that are likely to be found in clinical trial protocols, reports, regulatory guidelines, and published manuscripts… Fully comprehensive - provides definitions of clinical trial terms in one complete volume… Includes extensive use of graphs throughout." LA DOC STI

"…covers a range of subject matter, with emphasis on medical, statistical, epidemiological and ethical terms… a useful adjunct to standard clinical trial texts… a reference source to keep within easy reach." TALANTA

The Dictionary of Clinical Trials, Second Edition is a ‘must-have’ for all pharmaceutical companies who conduct a lot of clinical trials, in all or one therapeutic area. The book is also of interest for public health and health science workers, and for contract research organisations and departments of medicine, where medics are involved with clinical trials.

Summary: Skimpy, minimalist definitions and overpriced
Rating: 1

This is the sort of book that one might expect to receive as a "freebee" from a drug company representative. For $…, it is very overpriced. Considering that for around the same amount of money, one can buy a very thorough medical dictionary, this "book" falls short. Save your money and apply it towards a "real" text.

Summary: I use this every day !
Rating: 5

As a newcomer to the pharmaceutical industry, this book has helped me to understand the jargon that is everyday language for clinical research associates. Explanations are presented simply

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Handbook of Pharmaceutical Manufacturing Formulations: Liquid Products (Volume 3 of 6)
by: Sarfaraz K. Niazi
en | Informa HealthCare

0849317487 9780849317484 9781420048452

Handbook of Pharmaceutical Manufacturing Formulations: Liquid Products (Volume 3 of 6)
By Sarfaraz K. Niazi

Publisher: Informa HealthCare
Number Of Pages: 320
Publication Date: 2004-04-26
ISBN-10 / ASIN: 0849317487
ISBN-13 / EAN: 9780849317484

Product Description:

The third volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers liquid drugs, which include formulations of non-sterile drugs administered by any route in the form of solutions (monomeric and multimeric), suspensions (powder and liquid), drops, extracts, elixirs, tinctures, paints, sprays, colloidons, emulsions, aerosols, and other fluid preparations from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of generic and proprietary formulations. Each entry begins with a fully validated scaleable manufacturing formula and a summary of manufacturing process. The book provides a detailed discussion on the difficulties encountered in formulating and manufacturing liquid drugs, the common elements of formulation. The section on regulatory and manufacturing guidance deals with the topics of changes to approved NDAs and aNDAs, post-approval changes to semisolid drugs, global manufacturing practices and guidelines, compliance program guidance manual for FDA staff covering drug manufacturing inspections program, waiver of in vivo bioavailability studies for immediate release solid drugs based on a biopharmaceutics classification, in addition to providing quick tips on resolving the common problems in formulating uncompressed drugs.

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Pharmaceutical Perspectives of Cancer Therapeutics
by: Yi Lu, Ram I. Mahato

Pharmaceutical Perspectives of Cancer Therapeutics
By Yi Lu, Ram I. Mahato

Publisher: Springer
Number Of Pages: 602
Publication Date: 2009-07-21
ISBN-10 / ASIN: 1441901302
ISBN-13 / EAN: 9781441901309

Product Description:

The goal of our efforts in compiling Pharmaceutical Perspectives of Cancer Therapeutic is to produce a comprehensive yet easy-to-follow review of the principles and current approaches in this ever-growing field. With today’s broad research perspective and technology expertise, the knowledge in the field of cancer research and drug development has become a challenge not only for students who are eager to learn, but also for seasoned professionals who are willing to update. The complexity of cancer demands a comprehensive and integrated understanding from both cancer biology and pharmaceuticaldosage forms and drug delivery in order to warrant a successful therapeutic regimen. However, no book to date combinestogether these two aspects, namely the cancer research and the drug design and delivery from an integrated perspective of cancer treatment. Hence, a book that merges the knowledge from these two aspects is greatly desired.

For the purpose of bridging basic research and clinical application, pharmaceutical drug development processes and regulatory issues, drug design and delivery, laboratory and translational experimentation, marketing and postmarketing surveillance,we have invited international experts with a multi-disciplinary background, including scientists and clinicians from both academia and industries in theirrespective fields to contribute to this book. We intend to convey both an introductory understanding and the latest development in the field so that this book can be useful for both novice students and practicing scientists. With a comprehensive and integrated view of cancer therapeutics, we hope that this book will stimulate a deeper understanding and promote interaction in this integrated field for people with diverse expertise and backgrounds who are working on cancer therapeutics.

We have organized this book to cover a wide variety of topics including strategies to suppress tumor angiogenesis and metastasis, overcome multi-drug resistance in cancer, target telomerase and apoptosis pathways;therapeutic approaches to employ monoclonal antibody and cancer vaccines;introduction of new concepts such as cancer stem cells and new technologies such as nanobiotechnology, RNA interference, microRNA, and cancer cell gene profiling. The use of synthetic carriers, such as lipids, polymers and peptides for delivery and targeting of small molecules, proteins and nucleic acids to cancer cells or specific organs in vivo, as well as targeted delivery of macromolecular drugs to cancer cells, are described in detail. In addition, the utilization of imaging in cancer therapeutics, development and utilization of HIF-1 knockout animal models in cancer study, as well as the principles of developing anticancer drugs and designing clinical trials, are also discussed. In summary, this book provides an in-depth review of various aspects of anticancer strategies and drug delivery approaches from different perspectives, including detailed discussion of several clinical trial cases. The book has a wider and more involved focus on cancer therapy with a good balance on diversity. It integrates cancer therapy approaches (both biological- and small compound molecule-based therapy) with drug delivery. By reading this book, not only bench scientists can have an insight for what physicians desire for their clinical use towards cancer treatment, but also physicians will better understand how the approach and drug are developed and therefore will apply the drug more efficiently and accurately in patients. Moreover, this book summarizes current progress and state-of-the-art of cancer therapeutics, while focusing on the novel ideas that are being explored to overcome the existing challenges. We hope that this book will be served as both a refresher and ready-reference, as well as an educational tool, to both new entrants and seasoned researchers.

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Evidence-based Pharmacy
by: Phil Wiffen
en | Radcliffe Publishing

1857753844 9781857753844 9781417519958

Evidence-based Pharmacy
By Phil Wiffen

Publisher: Radcliffe Publishing
Number Of Pages: 168
Publication Date: 2001-06-29
ISBN-10 / ASIN: 1857753844
ISBN-13 / EAN: 9781857753844

Product Description:

This clear and concise book shows the reader how to answer basic questions such as: / does this treatment work? / What unwanted effects might a treatment give? / What is the best treatment for a given condition? / How can I extract useful information? The book explains the need for evidence-based medicine (EBM) and outlines the best ways to analyse and evaluate published information. It guides the reader in identifying the right evidence and assessing its value in day-to-day practice. The book includes a section on making best use of the Internet, shows the many uses of evidence in pharmacy and gives specific examples to illustrate key points. Useful appendices provide information on website addresses, journals and other publications from the Department of Essential Drugs and Medicines Policy. It is essential reading for pharmacists in hospitals, in the pharmaceutical industry and in the community, and for students of pharmacy.

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Public Relations for Pharmacists
by: Tina L. Pugliese
en | APhA Publications

1582120110 9781582120119 9780585357102

Public Relations for Pharmacists
By Tina L. Pugliese

Publisher: APhA Publications
Number Of Pages: 166
Publication Date: 2000-05-01
ISBN-10 / ASIN: 1582120110
ISBN-13 / EAN: 9781582120119

Product Description:

Equips pharmacy professionals with the tools necessary to advance their practice through public relations. The first book designed specifically for pharmacists, it explains how to work with the media; how to write news releases, public service announcements, and op-ed pieces; how to prepare for media interviews; how to work with PR agencies; and how to become involved in the community. The book contains lists of public relations do’s and don’ts, points to consider, and tips for succeeding. Examples of successful PR activities and campaign and sample news release, public service announcement, op-ed article, and media pitch letter are also included.

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Chemistry, Pharmacy and Revolution in France, 1777–1809 (Science, Technology and Culture, 1700–1945)
by: Jonathan Simon

Chemistry, Pharmacy And Revolution in France, 1777–1809 (Science, Technology and Culture, 1700–1945)
By Jonathan Simon

Publisher: Ashgate Publishing
Number Of Pages: 189
Publication Date: 2005-11-30
ISBN-10 / ASIN: 0754650448
ISBN-13 / EAN: 9780754650447

Product Description:

This book explores the history of pharmacy in France and its relationship to the discipline of chemistry as it emerged at the beginning of the nineteenth century. It argues that an appreciation of the history of pharmacy is essential to a full understanding of the constitution of modern science, in particular the discipline of chemistry. As such, it provides a novel interpretation of the chemical revolution (c. 1770 - 1789) that will, no doubt, generate much debate on the place of the chemical arts in this story, a question that has hitherto lacked sufficient scholarly reflection. Furthermore, the book situates this analysis within the broader context of the French Revolution, from duansci.com arguing that an intimate and direct link can be drawn between the political upheavals and our vision of the chemical revolution. The story of the chemical revolution has usually been told by focusing on the small group of French chemists who championed Lavoisier’s oxygen theory, or else his opponents. Such a perspective emphasises competing theories and interpretations of critical experiments, but neglects the challenging issue of who could be understood as practising chemistry in the eighteenth century. In contrast, this study traces the tradition of pharmacy as a professional pursuit that relied on chemical techniques to prepare medicines, and shows how one of the central elements of the chemical revolution was the more or less conscious disassociation of the new chemistry from this ancient chemical art.

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Metallothioneins in Biochemistry and Pathology
by: Paolo Zatta

Metallothioneins in Biochemistry and Pathology
By Paolo Zatta

Publisher: World Scientific Publishing Company
Number Of Pages: 336
Publication Date: 2008-10-15
ISBN-10 / ASIN: 9812778934
ISBN-13 / EAN: 9789812778932

Product Description:

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.

This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer’s and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Contents: Metallothionein in Neurological Disorders; Metallothionein in Oncology; Metallothionein in Cardiopathy; Metallothionein in Hepatology.

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Japanese Pharmacopeia (Pharmacopoeia of Japan) 15 Ed. 2006
by: Yakuji Nippo Ltd
en | Maruzen Company, Ltd.

4840809747 9784840809740

Japanese Pharmacopeia (Pharmacopoeia of Japan)
By Yakuji Nippo Ltd

Publisher: Maruzen Company, Ltd.
Number Of Pages: 1788
Publication Date: 2006-03
ISBN-10 / ASIN: 4840809747
ISBN-13 / EAN: 9784840809740

Product Description:

This is the English version of the 15th edition of the "Japanese Pharmacopoeia". It provides the official Japanese standard for the description and quality of drug substances and products. It contains over 1,300 articles regarding: general rules for preparations; processes and apparatus; monographs on drugs; and infrared reference spectra and ultraviolet-visible reference spectra.

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Outsourcing Clinical Development: Strategies for Working With CROs And Other Partners
by: Jane E. Winter, Jane Baguley

Outsourcing Clinical Development: Strategies for Working With CROs And Other Partners
By Jane E. Winter, Jane Baguley

Publisher: Gower Publishing Company
Number Of Pages: 170
Publication Date: 2006-01
ISBN-10 / ASIN: 0566086867
ISBN-13 / EAN: 9780566086861

Product Description:

The challenges facing large pharmaceutical companies are stark: sales are slowing and research and development costs are rising. There’s an overwhelming need to reduce development costs by as much as 30-40 per cent, whilst at the same time significantly shortening development cycle times. Pharmaceutical spend on outsourcing faces double-digit growth for the next three to five years and yet, if outsourcing is to meet these challenges, new models of collaborative and cooperative working are needed now. "Outsourcing Clinical Development" offers a guide to these new models and to future clinical outsourcing strategy. There is advice at a strategic level on the basis for an outsourcing strategy and how to work with CROs (clinical research outsourcers); geographical issues, such as low-cost environments. There’s also a detailed guide to selecting candidates, and managing the proposal, negotiation and contract process successfully; as well as reviewing the performance of your outsourcing and developing a strategic relationship in the longer term. The pharmaceutical outsourcing function is as complex and as influential a process as the clinical trials themselves. "Outsourcing Clinical Development", with a powerful mix of perceptive insight from leading lights in the industry, advice on long-term strategic direction and tools for immediate help is a must-have read for pharmaceutical companies and the CROs that support them.

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Forecasting for the Pharmaceutical Industry: Models for New Product And In-market Forecasting And How to Use Them
by: Arthur G., Ph.D. Cook

Forecasting for the Pharmaceutical Industry: Models for New Product And In-market Forecasting And How to Use Them
By Arthur G., Ph.D. Cook

Publisher: Gower Publishing Company
Number Of Pages: 141
Publication Date: 2006-11-18
ISBN-10 / ASIN: 0566086751
ISBN-13 / EAN: 9780566086755

Product Description:

In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month’s production schedule, to market estimates for drugs in the next decade. The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex ‘black box’ equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Art Cook’s highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. "Forecasting for the Pharmaceutical Industry" is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making.

Summary: Too simple
Rating: 2

If you do not know anything about forecasting techniques this is your book. The author give us a big picture about the main steps in the pharmaceutical industry forecasting. How ever if you already took an econometrics course or a business forecasting course this book it is not going to help you.

Summary: Nicely covers the broad areas of forecasting
Rating: 3

Nicely covers the broad areas of forecasting, and thats just what it does. It does not get in to the details. So if you are someone who wants to brush your knowledge then this is for you, but if you are looking to learn new methods then maybe you may want to look at some other options.

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Nanotherapeutics: Drug Delivery Concepts in Nanoscience
by: Alf Lamprecht

Nanotherapeutics: Drug Delivery Concepts in Nanoscience
By Alf Lamprecht

Publisher: Pan Stanford Publishing
Number Of Pages: 292
Publication Date: 2008-07-21
ISBN-10 / ASIN: 9814241024
ISBN-13 / EAN: 9789814241021

Product Description:

An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems allowing for innovative therapeutic approaches. Due to their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers, and intracellular drug delivery.

This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles,from duansci.com with each chapter discussing a specific disease (e.g. diabetes, cancer, inflammation, etc.) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. Written in a concise manner, readers will gain an insight into the basics of nanoparticle preparation as well as a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Contents: General Aspects of Nanotherapeutics: Nanocarriers in Drug Delivery - Design, Manufacture and Physicochemical Properties (C Schmidt & A Lamprecht); Transport Across Biological Barriers (N Nafee et al.); Targeting Approaches (S Cammas-Marion); Disease-Related Approaches by Nanotherapeutics: Nanoscale Cancer Therapeutics (Y Pellequer & A Lamprecht); Nanotherapeutics for Skin Diseases (N Atrux-Tallau et al.); Nanoparticles for Oral Vaccination (J M Irache et al.); Nanoparticles: Therapeutic Approaches for Bacterial Diseases (B Moulari); Nanoparticle Therapy in Parasites Diseases: Possibility and Reality! (M Larabi); Nanocarriers in the Therapy of Inflammatory Disease (A Lamprecht).

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Chemokine Receptors in Cancer (Cancer Drug Discovery and Development)
by: Amy M. Fulton

Chemokine Receptors in Cancer (Cancer Drug Discovery and Development)
By Amy M. Fulton

Publisher: Humana Press
Number Of Pages: 172
Publication Date: 2009-05-27
ISBN-10 / ASIN: 1603272666
ISBN-13 / EAN: 9781603272667

Product Description:

Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells.

Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.

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Drug Delivery Systems in Cancer Therapy (Cancer Drug Discovery and Development)
by: Dennis M. Brown

Drug Delivery Systems in Cancer Therapy (Cancer Drug Discovery and Development)
By Dennis M. Brown

Publisher: Humana Press
Number Of Pages: 400
Publication Date: 2003-11-15
ISBN-10 / ASIN: 0896038882
ISBN-13 / EAN: 9780896038882

Product Description:

Comprehensively reviews the drug delivery systems for cancer chemotherapy. Discusses the convention as well as the unconventional methods of drug administration and provides an overview of opportunities for future drug development. Focuses primarily on small molecule delivery. DNLM: Drug Delivery Systems–methods.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)
by: Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)
By Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

Publisher: Wiley
Number Of Pages: 480
Publication Date: 2009-07-27
ISBN-10 / ASIN: 0470227346
ISBN-13 / EAN: 9780470227343

Product Description:

This book gathers present knowledge on the involvement of ABC transporters in drug transport and resistance. Bringing together updated information from an otherwise-scattered field of scientific literature, this resource helps researchers in pharmaceutical science in discovering drugs able to counteract multidrug resistance in diseases like cancer. It examines ABC transporters not only at the cancer cell, but also in other important physiological localizations. This book covers these topics as well as the pharmaceutical and medicinal modulation and inhibition of ABC transporters, helping pharmaceutical researchers discover drugs to counteract multidrug resistance in diseases like cancer.

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Manufacturing of Pharmaceutical Proteins: From Technology to Economy
by: Stefan Behme

Manufacturing of Pharmaceutical Proteins: From Technology to Economy
By Stefan Behme

Publisher: Wiley-VCH
Number Of Pages: 404
Publication Date: 2009-03-16
ISBN-10 / ASIN: 3527324445
ISBN-13 / EAN: 9783527324446

Product Description:

This comprehensive introduction covers all aspects of biopharmaceutical manufacturing, including technology and facilities, GMP and regulatory issues, as well as costing and timeline aspects for supply chain implementation.

Written by a leading expert at one of the largest pharmaceutical companies worldwide, this practical text is aimed at a wide audience ranging from libraries, via biotech companies to students and technicians planning to enter biopharmaceutical manufacturing. In addition, it is well suited for academic teaching as well as internal training within larger biotech or pharmaceutical companies.

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New Bacterial Vaccines (Medical Intelligence Unit)
by: Ronald W. Ellis, Bernard R. Brodeur

New Bacterial Vaccines (Medical Intelligence Unit)
By Ronald W. Ellis, Bernard R. Brodeur

Publisher: Springer
Number Of Pages: 376
Publication Date: 2003-11-30
ISBN-10 / ASIN: 0306478323
ISBN-13 / EAN: 9780306478321

Product Description:

New Bacterial Vaccinesfocuses upon unfulfilled needs for bacterial vaccines. The increase in drug resistance among many bacterial species has increased the need for new bacterial vaccines. This book serves as a comprehensive reference on the major aspects of developing new bacterial vaccines. The distinctive feature of this book is that it focuses upon new vaccines now under development by reviewing key issues for each vaccine target and new technologies being applied to developing new vaccines. This book should prove useful for students in the life sciences, scientists, developers of vaccines and biotechnology products, clinicians, regulators, and health-care practitioners.

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Drug Toxicokinetics (Drug and Chemical Toxicology)
by: Welling
en | Informa HealthCare

0824790197 9780824790196 9780585399867

Drug Toxicokinetics (Drug and Chemical Toxicology)
By Welling

Publisher: Informa HealthCare
Number Of Pages: 432
Publication Date: 1993-05-13
ISBN-10 / ASIN: 0824790197
ISBN-13 / EAN: 9780824790196

Product Description:

This reference/text examines the importance of toxicokinetics on drug disposition and outlines its practical applications in drug development - helping readers incorporate the most up-to-date findings into their own work.;Consolidating research from international authorities in the fields of toxicology, pharmacokinetics, metabolism and biochemistry to illustrate the interdisciplinary nature of toxicokinetic situations, Drug Toxicokinetics: covers regulatory guidelines for conducting toxicokinetic studies to obtain maximum information for safety assessment and clinical use of drug candidates; illustrates the principles of linear and nonlinear pharmacokinetics and compares them to toxicokinetics; displays relationships between the time-span of drug concentrations in the body and the appearance of toxic effects; and spotlights problems and solutions regarding metabolism impact in toxicology as well as the bioactivation of drugs.;Containing over 950 literature citations, figures and tables, Drug Toxicokinetics is intended as a reference for pharmacists; organic and medicinal chemists; industrial, academic and government pharmacologists and toxicologists; pharmacokineticists; safety-evaluation scientists; pathologists and biochemists. It should also be a useful guide for personnel in public health, risk assessment, chemical industry, drug metabolism and drug regulatory affairs as well as for clinical and preclinical drug development scientists. The book should also serve as a useful text for upper-level undergraduate and graduate students in these disciplines.

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Pharmacy Case Studies
by: Soraya Dhillon, Rebekah Raymond

Pharmacy Case Studies
By Soraya Dhillon, Rebekah Raymond

Publisher: Pharmaceutical Press
Number Of Pages: 458
Publication Date: 2009-02-28
ISBN-10 / ASIN: 0853697248
ISBN-13 / EAN: 9780853697244

Product Description:

Whilst most pharmacy undergraduate texts are subject specific, "Pharmacy Case Studies" encourages students to take an integral approach to pharmacy via a series of pharmacy cases. Knowledge gained within the individual areas of law and ethics, pharmaceutics, pharmacology and pathology are tested by each example, bringing together all areas taught on the degree course. Each chapter contains five case studies, starting with uncomplicated cases and increasing in complexity as they expand.

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Martindale’s Drugs Restricted in Sport 2009 Pocket Companion
by: Sean Sweetman

Martindale’s Drugs Restricted in Sport 2009 Pocket Companion
By Sean Sweetman

Publisher: Pharmaceutical Press
Number Of Pages: 528
Publication Date: 2009-03-31
ISBN-10 / ASIN: 0853698708
ISBN-13 / EAN: 9780853698708

Product Description:

This is a unique guide to drugs restricted in sport. This is an A-Z guide by drug name (INN) of over 450 drugs restricted in sport. Each drug monograph has a regular structure containing a list of synonyms, drug profile (medical use), World Anti-Doping Agency (WADA) classification; restriction in sport (in and out of competition); and a list of single and multi-ingredient proprietary preparations containing the drug from 40 countries worldwide (Martindale data).

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British National Formulary 57: March 2009
by: Joint Formulary Committee

British National Formulary 57: March 2009
By Joint Formulary Committee

Publisher: Pharmaceutical Press
Number Of Pages: 978
Publication Date: 2009-04-02
ISBN-10 / ASIN: 0853698457
ISBN-13 / EAN: 9780853698456

Product Description:

This is the authoritative guide to prescribing, dispensing and administering medicines for all health care professionals. Nobody working in health care can afford to be without the latest edition of "BNF". Compiled with the advice of clinical experts and continually updated to reflect the latest evidence from all credible sources worldwide, this essential reference provides up-to-date guidance on prescribing, from duansci.com dispensing, administering, and monitoring medicines. Not only does the "BNF" include the widely accepted framework for the drug management of common diseases, it also includes details of medicines prescribed in the UK, with special reference to their uses, cautions, contraindications, side-effects, dosage and relative costs. This allows treatment to be tailored to the individual needs of each patient. Updated in print every six months by an expert team of pharmacists, with guidance and validation from a network of leading clinicians, and oversight by a Joint Formulary Committee with representatives from all spheres of clinical practice. "The BNF" reflects current best practice as well as legal and professional guidelines relating to the use of medicines. As a result it is used widely as a touchstone reference, and cited in Parliaments and courts as a source of authority. This title is available online as part of MedicinesComplete, on PDA and on CD-ROM for intranets.

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Physicochemical Principles of Pharmacy, 4th Edition
by: A. T. Florence, David Attwood

Physicochemical Principles of Pharmacy, 4th Edition
By A. T. Florence, David Attwood

Publisher: Pharmaceutical Press
Number Of Pages: 492
Publication Date: 2005-12-30
ISBN-10 / ASIN: 085369608X
ISBN-13 / EAN: 9780853696087

Product Description:

Physical chemistry is the basis of rational pharmaceutical formulation and processing, and is fundamental to understanding the complexities of drug delivery and drug absorption. This textbook presents the physiochemical principles useful to the modern pharmaceutical scientist and pharmacist.

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G Protein-Coupled Receptors in Drug Discovery (Methods in Molecular Biology, 552)
by: Wayne R. Leifert

G Protein-Coupled Receptors in Drug Discovery (Methods in Molecular Biology)
By Wayne R. Leifert

Publisher: Humana Press
Number Of Pages: 376
Publication Date: 2009-06-29
ISBN-10 / ASIN: 1603273166
ISBN-13 / EAN: 9781603273169

Product Description:

The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, experts in the field provide a range of classic and cutting-edge laboratory protocols developed for GPCR research, as well as several current review articles relevant to the area of high throughput GPCR screening, from duansci.com with discussion on GPCR structure and GPCR signalling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy to use, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols serves to aid all those who wish to further the vital research in their GPCR drug discovery programs.

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Davis’s Pocket Clinical Drug Reference
by: Shamim Tejani, PharmD, Cynthia Sanoski

Davis’s Pocket Clinical Drug Reference
By Shamim Tejani, PharmD, Cynthia Sanoski

Publisher: F A Davis Co
Number Of Pages: 225
Publication Date: 2009-02-28
ISBN-10 / ASIN: 0803620780
ISBN-13 / EAN: 9780803620780

Product Description:

Make sure your students rely on a trusted reference! This handy pocket guide shows them how to safely administer medications to their adult, pediatric, and geriatric patients, as well as pregnant and lactating women, and those with renal impairments.

Every detail is designed to make it easy for your students to find the information they need in a snap. And, they can count on it for accuracy because it s drawn from Davis s Drug Guide database.

OUTSTANDING FEATURES

*4 x 7 size fits in a scrub pocket.
*Nearly 1,000 abbreviated drug monographs, organized alphabetically by generic name, deliver must-know
information, including…
Trade name
Indications
Drug class
Pregnancy categories
Contraindications
Adverse drug reactions and side effects
Interactions
Dosing information for adult, pediatric, and geriatric patients, pregnant and lactating women, and renal impairment
Generic availability
Monitoring information
*Very important or life-threatening information, such as FDA black box warnings or adverse drug reactions, appears in red type.
*A colored thumb tab makes it easy for your students to find information quickly.
*The appendices features Cytochrome P450 enzyme table, Pediatric IV, immunization guidelines, and more.
*Abbreviations key appears in the front of the book and at the bottom of each page.*
Notes section covers patient safety information.
*Index provides generic and trade drug names.

Summary: Davis’s Drug Reference
Rating: 5

Super reference well structured and well written as a handy reference. Good for those at all levels who need rapid answers. Useful to for publishers to consider an online version.

eyedaktari

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Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2007
by: United Nations
en | United Nations

9211482259 9789211482256 9781435644151

Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2007
By United Nations

Publisher: United Nations
Number Of Pages: 92
Publication Date: 2008-05-03
ISBN-10 / ASIN: 9211482259
ISBN-13 / EAN: 9789211482256

Product Description:

To prevent the diversion of precursor chemicals for use in the illicit manufacture of drugs, governments must have adequate legislation in line with the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances as well as effective working mechanisms and procedures for information feedback between the authorities involved in the control of precursor chemicals. duansci.com The International Narcotics Control Board in its annual report examines actions taken recently and highlights both successful results and shortcomings.

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Handbook of Herbs and Spices - Volume 3
by: K.V. Peter
en | Woodhead Publ / CRC

1845690176 9781845690175 9781845691714 1845691717 9780849391552 0849391555

Handbook of Herbs and Spices:Volume
By K.V. Peter

Publisher: Woodhead Publishing
Number Of Pages: 568
Publication Date: 2006-08-30
ISBN-10 / ASIN: 1845690176
ISBN-13 / EAN: 9781845690175
Introduction:
Herbs and spices play a pivotal role in the day-to-day life of mankind as important
flavouring agents in foods, beverages and pharmaceuticals and also as ingredients in
perfumes and cosmetics. The manufacturers of foods, beverages, cosmetics and
pharmaceuticals are responding to the growing wave of consumer resistance and
legislative limitations set for products containing chemical additives. Spices as sources
of natural colours and flavours present welcome opportunities in the international
market. The nutritional, antioxidant, antimicrobial and medicinal properties of spices
also have widespread applications.

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Handbook of Herbs and Spices, Volume 1 (Woodhead publishing in food science and technology)

Handbook of Herbs and Spices (Woodhead publishing in food science and technology)
By K.V. Peter

Publisher: Woodhead Publishing Ltd
Number Of Pages: 336
Publication Date: 2001-07
ISBN-10 / ASIN: 1855735628
ISBN-13 / EAN: 9781855735620
Binding: Hardcover

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Handbook of Herbs and Spices - Volume 2
by: K V Peter
en | CRC / Woodhead Publ

9780849325359 9781855737211 9781855738355 0849325358 1855737213

Handbook of Herbs and Spices
By K.V. Peter

——————————————————————————–

Publisher: Woodhead Publishing Ltd
Number Of Pages: 376
Publication Date: 2004-04
ISBN-10 / ASIN: 1855737213
ISBN-13 / EAN: 9781855737211
Binding: Hardcover
Hardcover: 376 pages
Publisher: Woodhead Publishing Ltd; 2Rev Ed edition (April 2004)
ISBN-10: 1855737213
ISBN-13: 978-1855737211

Alternate ISBNs:

Woodhead Publishing ISBN 1 85573 721 3 (book)
ISBN: 1 85573 835 X (e-book)
CRC Press ISBN 0-8493-2535-8
CRC Press order number: WP2535

Summary:

Herbs and spices are among the most versatile and widely used ingredients in food processing. As well as their traditional role in flavouring and colouring foods, they have increasingly been used as natural preservatives and for their potential health-promoting properties. The Handbook of Herbs and Spices Volume 2 provides an essential reference for manufacturers wishing to make the most of these important ingredients. The main body of the handbook consists of 15 chapters covering key spices and herbs. Chapters cover key issues from definition and classification to chemical structure, cultivation, uses in food processing, functional properties and quality issues.

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The Practice of Medicinal Chemistry, Third Edition
by: Camille Georges Wermuth
en

0123741947 9780123741943 9780080568775

The Practice of Medicinal Chemistry, Third Edition
By Camille Georges Wermuth

Publisher: Academic Press
Number Of Pages: 982
Publication Date: 2008-07-23
ISBN-10 / ASIN: 0123741947
ISBN-13 / EAN: 9780123741943
Binding: Hardcover

Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery/development phases more quickly. This third edition still stands as the only source for practical aspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery.

NEW TO THIS EDITION:
* Focus on chemoinformatics and drug discovery
* Enhanced pedagogical features
* New chapters including:
- Drug absorption and transport
- Multi-target drugs
* Updates on hot new areas:
NEW! Drug discovery and the latest techniques
NEW! How potential drugs can move through the drug discovery/ development phases more quickly
NEW! Chemoinformatics

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Introduction to Medicinal Chemistry : How Drugs Act and Why
by: Alex Gringauz

Introduction to Medicinal Chemistry: How Drugs Act and Why
By Alex Gringauz

——————————————————————————–

Publisher: Wiley-VCH
Number Of Pages: 736
Publication Date: 1996-12-27
ISBN-10 / ASIN: 0471185450
ISBN-13 / EAN: 9780471185451
Binding: Hardcover

——————————————————————————–

Book Description:

This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today’s pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents.

——————————————————————————–

Summary: minimal coverage of medicinal chemistry
Rating: 2

Anyone wishing a more comprehensive treatment should utilize Foye’s Medicinal Chemistry or Goodman and Gillmans work.

Summary: Almost Perfect!
Rating: 4

This book is very good introduction in the major aspects of the chemistry of the drugs. It explains with good schemes the reactions of drugs and others important mechanisms. But in my opinion it is necessary a chapter to explains the analytical methods that are being used nowadays in this field like HPLC,NMR,Mass spectroscopy and so on, for searching the drugs process thru the living system.

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An Introduction to Medicinal Chemistry
by: Graham L. Patrick
en

0198558724 9780198558729

Presents a complex subject in a clear, readable manner. In places, it even manages to be amusing.

Editorial Reviews

Review
`Review from previous edition …presents a complex subject in a clear, readable manner. In places, it even manages to be amusing.’ New Scientist

`… informative, easy to read and the illustrations are particularly instructive … mathematical principles are handled sympathetically and with more clarity than I have seen elsewhere … this is a well produced, informative and readable book, and provides excellent value for money.’ Education in Chemistry, November 1995

"(The book is distinguished by) Professor Glenn’s enormous breadth of knowledge about the great legal traditions of the world…the genuine effort towards an understanding of other cultures, and the great capacity of the author to express (himself) clearly and directly." Verfassung und Recht in Ubersee Summer 2001

"Of interest not only to students of law, but to anyone concerned with intercultural dialogue." Verfassung und Recht in Ubersee Summer 2001

"This book can be warmly recommended to students as an affordable introduction to medicinal chemistry". The Royal Society of Chemistry, 2002.

"Through appropriate graphics and very good explanations, this book allows the student to acquire a sound understanding of the development of medicines, even without having a previous strong grounding in biochemistry." Reto Mueller, Organische Chemie.

Book Description
NEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * adrenergics * drug discovery and drug development

Book Info
St. George’s Hospital Medical School, London, U.K. Softcover version. –This text refers to the Paperback edition.

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Constituents of Medicinal Plants: An introduction to the chemistry and therapeutics of herbal medicine
by: Kerry Bone
en

0851998070 9780851998077

Taschenbuch: 184 Seiten
Verlag: Cabi; Auflage: 2nd (29. April 2004)
Sprache: Englisch
ISBN-10: 0851998070
ISBN-13: 978-0851998077

During recent years herbal medicine has become an increasingly scientifically based system of healing. Due to demands from both the public and medical establishments, studies leading to the scientific explanation of plant therapeutic capabilities are allowing this practice to gain increasing credibility and acceptance within the medical community. This book draws on the recent research and provides an introduction to the complex area of plant constituents and the therapeutic activities associated with them. Plants covered are those commonly used by herbalists throughout Europe, North America and Australasia.

During recent years herbal medicine has become an increasingly scientifically based system of healing. Due to demands from both the public and medical establishments, studies leading to the scientific explanation of plant therapeutic capabilities are allowing this practice to gain increasing credibility and acceptance within the medical community. This book draws on the recent research and provides an introduction to the complex area of plant constituents and the therapeutic activities associated with them. Plants covered are those commonly used by herbalists throughout Europe, North America and Australasia.

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Virtual Screening for Bioactive Molecules (Methods and Principles in Medicinal Chemistry)
by: Hans-Joachim Böhm, Gisbert Schneider, Hugo Kubinyi, Raimund Mannhold, Hendrik Timmerman
en

3527301534 9783527301539 9783527613090

Virtual Screening for Bioactive Molecules (Methods and Principles in Medicinal Chemistry)
By Hans-Joachim Böhm, Gisbert Schneider, Hugo Kubinyi, Raimund Mannhold, Hendrik Timmerman

Publisher: Wiley-VCH
Number Of Pages: 325
Publication Date: 2000-11-21
ISBN-10 / ASIN: 3527301534
ISBN-13 / EAN: 9783527301539
Binding: Hardcover

Recent progress in high-throughput screening, combinatorial chemistry and molecular biology has radically changed the approach to drug discovery in the pharmaceutical industry. New challenges in synthesis result in new analytical methods. At present, typically 100,000 to one million molecules have to be tested within a short period and, therefore, highly effective screening methods are necessary for today’s researchers - preparing and characterizing one compound after another belongs to the past. Intelligent, computer-based search agents are needed and "virtual screening" provides solutions to many problems. Such screening comprises innovative computational techniques designed to turn raw data into valuable chemical information and to assist in extracting the relevant molecular features.

This handbook is unique in bringing together the various efforts in the field of virtual screening to provide the necessary methodological framework for more effective research. Leading experts give a thorough introduction to the state of the art along with a critical assessment of both successful applications and drawbacks. The information collated here will be indispensable for experienced scientists, as well as novices, working in medicinal chemistry and related disciplines

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Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (Methods and Principles in Medicinal Chemistry)
by: Klaus Wanner, Georg Höfner
en

3527314563 9783527314560 9783527610914

Publisher: Wiley-VCH
Number Of Pages: 460
Publication Date: 2007-04-20
Sales Rank: 1874931
ISBN / ASIN: 3527314563
EAN: 9783527314560
Binding: Hardcover
Manufacturer: Wiley-VCH
Studio: Wiley-VCH

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of www.duansci.com/read multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory.
Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands — all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

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Midwives, Society and Childbirth: Debates and Controversies in the Modern Period
by: Hilary Marland (Editor), Anne Marie Rafferty (Editor)
en | Routledge

0203435893 9780203435892

Midwives, Society and Childbirth: Debates and Controversies in the Modern Period
By Hilary Marland (Editor), Anne Marie Rafferty (Editor)

Publisher: Routledge
Publication Date: 1997-07-01
ISBN-10 / ASIN: 0203435893
ISBN-13 / EAN: 9780203435892

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Secrets of Methamphetamine Manufacture, Third Edition

Secrets of Methamphetamine Manufacture, Third Edition
By Uncle Fester

Publisher: Festering Publications
Number Of Pages: 214
Publication Date: 2005-02-15
ISBN-10 / ASIN: 0970148569
ISBN-13 / EAN: 9780970148568
Binding: Paperback

This classic of clandestine chemistry is back in all its glory in a 7th edition. Virtually every possible way to make meth is covered in detail, with some emphasis given to the popular methods starting with decongestant pills. Hardware store sources of many of the required chemicals are detailed along with low profile methods of obtaining other needed ingredients. I also include an update sheet with the book to keep it up to date in this rapidy changing field.

Summary: "The Secrets of How To Kill Yourself"
Rating: 1

Maybe some day the author of this book will hit rock bottom and find himself ripping out his decaying teeth with a pair of channel locks in the back shed of his trailer and realize how he has completely wasted his life and many of the other lives that this sham of a book has come in contact with.

Summary: Interesting for the curious, but way too advanced for anyone without chemist experience
Rating: 3

I just got the book because I was curious about how it was made (I’m curious about a lot of things that I would never actually make). The new TV series ‘Breaking Bad’ is what piqued my curiosity (a great show, by the way).

Now, just to give you an idea what you’d be getting here if you order this book, let me give you some info on me… I have an IQ of 130, and graduated with a 4.0 from college many years ago (electronics major), and currently work in computer security for a extremely large international company. I aced college-prep chemistry in high school, but did not take any in college.

I could follow enough of this book to satisfy my general curiosity, but there’s no way I could actually make the stuff from reading this book alone (even if I’d wanted). It would definitely take some college level chemistry to follow the book well enough to actually make the stuff without killing yourself. (There are some safety things not mentioned in this book, that are assumed anyone with college chemistry should know… thangs that could literally kill you if you don’t know).

Thus my 3 star averaged rating….
It is ‘great’ if you have a chemistry background… ‘good’ if you are very smart and just curious (but no chemistry background)…. and ‘poor’ if you are a layperson thinking this book will help you cook up something illegal.

Summary: very professional, easy to follow
Rating: 5

If you dont have at least a year of organic chem to your name, or are looking for a quick recipe, dont buy this book. It wont be of any use to you. As for myself, I am a chemistry major and am currently in the midst of my third year of organic chemistry. I find this book easy to follow, all of the procedures in this book that I have preformed worked nicely, and produced product of the highest quality. There are a few unforeseen events that will occur in the labwork, but are easily sidestepped by a good chemist. Most, or all of the lab equipment can be purchased on ebay for very reasonable prices; he also shows you how to manufacture all of your starting materials that would otherwise be almost impossible to purchase. Fester also shows you how to remove from you dope-the pollutants that ruin the finer aspects of methamphetamine. If you dont want to spend months going through the journal of the american chemical society, you should buy this book, which is basically a compilation and expansion of these journals. I highly recommend this book to the experienced dope cook that wants to feel what it’s like to pump out his first 400 gram batch of high quality drugs

Summary: Great info
Rating: 5

This book is full of great info if you want to spend large amounts of time in prison and ruin peoples lives with addictive poison.

Summary: DISAPPOINTED
Rating: 1

I was a bit disappointed with the content of this manual. I thought that it would have given me instructions and recipes in layman terms. These book is designed only chemist, and the trained professional chemist at that.

I work for a drug rehab center in the Virgin Islands and I want my patients to actually see what caustic items go into their systems when they use this stuff

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Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, and Other Psychedelic Amphetamines
by: Fester Uncle Fester

Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, and Other Psychedelic Amphetamines
By Uncle Fester

Publisher: Loompanics Unlimited
Number Of Pages: 213
Publication Date: 2005-03
ISBN-10 / ASIN: 1559502428
ISBN-13 / EAN: 9781559502429
Binding: Paperback

For nearly 20 years now I have been training champions, the champions of the field of clandestine chemistry. This book is their training ground.

I cover virtually every possible method of making that "food of the God’s" - meth along with how to make it from commonplace materials. I also give coverage of the history of this field, so that newcomers can quickly feel like old pros.

Beyond that, I also supply news inserts with the books so that the latest patents don’t leave you in the dust in this rapidly evolving field. This is the place to get up to speed and up to date in this hot area of study.

——————————————————————————–

Summary: Needs more work
Rating: 2

I think the book lacked proper illustrations. In one instance the author refers to a black and white sketch when he says "Making a claisen adapter, as shown in figure 5, is self explanatory". It looks like there is a cork on one end but what material is the rest made of? When working with chemicals, the material your equiptment is made of can be crucial or lifesaving.The author often gets sidetracked with different versions of a recipe. Maybe a different edition would be better?

Summary: Can’t Find Book Read This
Rating: 5

This is a great book that is a little inaccessible to newby chemists, but it’s about as simple as the process can be explained. And if you can’t understand it you’re liable to blow yourself up so I would try something else, theoretically speaking. Since Amazon wont sell this I would direct all interested parties to the Loompanics Unlimited catalog. That’s a great catalog in general, and it sells the most updated edition of this book plus others by the author. It also has several other great books. Cheers.

Summary: Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, and Other Psychedelic Amphetamines
Rating: 3

while the info is really in this book, it is very hard to read an I feel could be written in more of a layman’s term.

Summary: Study hard…
Rating: 5

Finally a resource for the "cooks" out there who know absolutely nothing about what they are doing and end up blowing up their house, or worse yet, their children. "Joe Blow" next door decides he’s gonna make some meth and then the cash will roll in, ignoring the fact that the chemicals he’s bringing into the neighborhood could very well kill. Maybe, just maybe, this book can cut the casualties of production.

Summary: Secrets of Methamphetamine Manufacture
Rating: 5

This is a wonderful compilation of valuable information by one the great american pioneers of our time! Uncle Fester is the reigning king of the underground enthusiast!

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Tyler’s Herbs of Choice: The Therapeutic Use of Phytomedicinals, Third Edition (Tylers Herbs of Choice)
by: Dennis V.C. Awang

Tyler’s Herbs of Choice: The Therapeutic Use of Phytomedicinals, Third Edition (Tylers Herbs of Choice)
By Dennis V.C. Awang

Publisher: CRC
Number Of Pages: 296
Publication Date: 2009-05-04
ISBN-10 / ASIN: 0789028093
ISBN-13 / EAN: 9780789028099

Product Description:

Today’s health care professionals are increasingly confronted with patients who are using herbal supplements to treat various conditions. Providing an authoritative introduction to botanical medicine for these professionals, this book combines the various scientific fields of herbal medicine, phytomedicine, and pharmacognosy with the modern clinical trials that support the rationale for using plant products in health care. This third edition features new information on herb-drug interactions as well as on diabetes, migraine headaches and the common cold, and flu. With updated references, the text presents the latest organic chemical reporting, including nomenclature, and plant taxonomy.

Summary: A "must" for all herbal remedies reference collections.
Rating: 5

Tyler’s Herbs of Choice provides an important treatise on the therapeutic use of phytomedicinals (herbal remedies) and provide important information on the most effective herbs, what they do, how they work. This is not for the casual reader: technical medical descriptions of common conditions and treatments cover details doctors will need to know and provide explanations of how the herbs interact with the body, and what constitutes acceptable levels of dosage.

Summary: An old school viewpoint?
Rating: 3

Written by two pharmacognosists at Perdue University, this book is an update to the original volume in 1994, describing the safe use of the most widely available medicinal herbs. They address recent developments in the use of herbal medicines in a manner that is easy to read and without unnecessary jargon. They include some updated references for most plants, encompassing the clinical literature, known chemical constituents, and the history of their use. Introductory essays describe the basic principles of herbal medicine and problems that the regulatory authorities have had in attempting to deal with these products, especially since the passage of the Dietary Supplement Health and Education Act (DSHEA). The chapters are arranged by general therapeutic indication and discuss the herbs used to treat various ailments and their reported efficacy based on clinical or preclinical results.

One obvious distinction of the book is the clear message that classical pharmacognosy is the only valid scientific viewpoint. There is still in this updated edition, the strong notion that there is a magic bullet within each plant that we only need identify and standardize. But this is seldom as straightforward as it may appear. For example, in the basic principles section there is praise of standardized preparations of hypericum, yet no acknowledgment that standardization based on hypericin is probably not useful, since it is no longer believed to be essential for the antidepressant activity of St. John’s Wort. Standardization and pharmacology of the currently favored constituent, hyperforin, was not mentioned. Publication in a scientific journal does not make a particular finding (e.g. hypericin inhibition of MAO) a "fact." Subsequent studies showed no MAO inhibition with pure hypericin. Conclusions and extrapolations drawn from results of in vitro studies are based on the conventional wisdom, which is often incorrect. While proposing a mechanism of action is a worthy goal, it must be remembered that true drug mechanisms (even the synthetic ones) are still beyond our medical understanding in most cases, particularly for psychotherapeutic medications. For example, while SSRI’s are known to act by blocking reuptake of serotonin, the connection between serotonin uptake and antidepressant action still remote.

Also mentioned as "pseudoscience" is the notion that whole herbs are more effective than their isolated active constituents. The basic principles section states that for every example in support of this statement that there is at least one denying it. While a 50:50 ratio hardly seems in itself a reasonable criterion for pseudoscience, I think one would be hard pressed to give one example of constituents being more effective than the whole herb for every example of the inverse. While I completely agree that hyperbole and sometimes outright fabrication are seen in the marketing of herbals, we shouldn’t be too quick to categorically discount what herbal practitioners have been saying for so long, but rather to weight them with the same standards as ideas that the "scientists" have generated.

Summary: Wait for the paperback or use the older version
Rating: 3

I have been waiting for an update of this classic book. However, for most health care professionals or herb users, I don’t feel the $40 price tag makes this book worth it. Wait for the paperback of this updated version or get the paperback 1994 version.

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Drug Targeting: Strategies, Principles, and Applications (Methods in Molecular Medicine)
by: G. E. Francis (Editor), Cristina Delgado (Editor)
en

089603531X 9780896035317 9780585395098

Drug Targeting: Strategies, Principles, and Applications (Methods in Molecular Medicine)
By G. E. Francis

Publisher: Humana Press
Number Of Pages: 320
Publication Date: 2000-04-01
ISBN-10 / ASIN: 089603531X
ISBN-13 / EAN: 9780896035317

Product Description:

G. E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today’s emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

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Opioid Research: Methods and Protocols (Methods in Molecular Medicine)
by: Zhizhong Z. Pan
en

158829059X 9781588290595 9781592593798

Publisher: Humana Press
Number Of Pages: 308
Publication Date: 2003-04-08
Sales Rank: 3520261
ISBN / ASIN: 158829059X
EAN: 9781588290595
Binding: Hardcover
Manufacturer: Humana Press
Studio: Humana Press
Average Rating: 0
Total Reviews: 0

This comprehensive collection of the major cross-disciplinary methods and protocols used in current opioid research covers topics ranging from molecular and genetic techniques, to behavioral analyses of animal models and to clinical practices. The well-practiced authors describe their best molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways, as well as for mapping the distribution and detecting the expression levels of opioid receptors, opioid peptides, and their messages in both brain tissues and individual cells. Also included are methods for the creation of in vitro and in vivo animal models to study opioid functions, as well as the clinical applications in the treatment of pain and opioid addiction.

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Vaccine Adjuvants: Preparation Methods and Research Protocols (Methods in Molecular Medicine)
by: Derek T. O’Hagan
en

0896037355 9780896037359 9781592590834

Publisher: Humana Press
Number Of Pages: 352
Publication Date: 2000-04-15
Sales Rank: 1841149
ISBN / ASIN: 0896037355
EAN: 9780896037359
Binding: Hardcover
Manufacturer: Humana Press
Studio: Humana Press

Derek T. O’Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today’s researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.

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Inside Dope: How Drugs Are the Biggest Threat to Sports, Why You Should Care, and What Can Be Done About Them
by: Richard W. Pound

Inside Dope: How Drugs Are the Biggest Threat to Sports, Why You Should Care, and What Can Be Done About Them
By Richard W. Pound

Publisher: Wiley
Number Of Pages: 248
Publication Date: 2006-09-29
ISBN-10 / ASIN: 0470837330
ISBN-13 / EAN: 9780470837337

Product Description:

An IOC insider speaks out on creating a drug-free sports culture

With doping charges leveled at athletes in baseball, cycling, and in the Olympics, cheating has, to many onlookers, become the norm in pro sports. With implications far beyond the sports arena, Inside Dope examines the genesis of doping in sports as well as in the world of doctors and trainers; drug testing and the battle to stay ahead of users; drug companies and big business; and the role of the World Anti-Doping Agency (WADA) as watchdog. Written by a former Olympian, an IOC official, and a passionate advocate of fair play in sports, this eye-opening book takes a candid look at testing standards and the future of doping and sports and the larger issue of how doping affects the public perception of athletes.

Summary: Bad
Rating: 1

Little insight, boring writing and a lack of any intelligible point. Save your money on this overpriced collection of paper.

Summary: Inside Dope: Not even close
Rating: 1

If you are interested in the wide-spread doping in professional (and amateur?) cycling, Pound’s book doesn’t even come close to an account that will inform, save for one point. Pound raises, albeit indirectly, the question for all professional atheletes: if one is to perform in order to win, and winning is the only consideration, then one has to chose to dope or run clean. Pound spends about 80% of the book sidestepping that issue while pontificating and lecturing from psuedo-case studies that are not really relevant to the cycling issues. The remaining 20% of the book was a lecture from an all-knowing elder who has never participated in cycling or running at a high level of competition: don’t do this, don’t do this, etc. I was interested in what Pound had to say at the beginning, but by the end I felt this book was a waste of time and money. I think Pound should stick to the WADA issues that could actually improve testing and oversight of all sport, specifically cycling.

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LSD, my problem child
by: Albert Hofmann

LSD, my problem child
By Albert Hofmann

Publisher: McGraw-Hill
Number Of Pages: 209
Publication Date: 1980
ISBN-10 / ASIN: 0070293252
ISBN-13 / EAN: 9780070293250

Product Description:

This is the story of LSD told by a concerned yet hopeful father, organic chemist Albert Hofmann. He traces LSD’s path from a promising psychiatric research medicine to a recreational drug sparking hysteria and prohibition.

We follow Dr. Hofmann’s trek across Mexico to discover sacred plants related to LSD, and listen in as he corresponds with other notable figures about his remarkable discovery.

Underlying it all is Dr. Hofmann’s powerful conclusion that mystical experience may be our planet’s best hope for survival. Whether induced by LSD, meditation, or arising spontaneously, such experiences help us to comprehend "the wonder, the mystery of the divine‹in the microcosm of the atom, in the macrocosm of the spiral nebula, in the seeds of plants, in the body and soul of people."

More than sixty years after the birth of Albert Hofmann’s problem child, his vision of its true potential is more relevant, and more needed, than ever.

Summary: Enlightening but not Riveting
Rating: 3

While this book does share some of the background on the development of LSD and investigations into other natural physchedelics by Hofmann et.al., the book is as eloquent as you would expect a translated book originally written by a German chemist. Hofmann also shares his and many other peoples’ personal trials with LSD, and delves into the spiritual mysticism of the drug. I would recommend it for the more science-minded individuals.

Summary: a third way through book. fascinating. RIP Albert
Rating: 5

Clears up a lot of the misconceptions. Got book through drug legalization lobby I give money to. What a Brilliant guy!!

Summary: The Ultimate Perscription
Rating: 5

There are a few books in the world that are touchstones for our psyches. This is one of them. It should be read by all young people coming of age, regardless of their position on the use of mind altering substances. It should be re-read every 10 years or so as they mature and their world view evolves. For those experienced with exploring internal frontiers it should be checked in with every 10 years or so as well. In just 209 pages of straight forward text some of the fundamental first principles of reality, and our relationship to it, are spilled out onto us without the need for preaching, screeching, moralizing, or deciphering obscure philosophical and scientific texts.

It should be read by every political leader in the world, and you won’t find too many people who’d disagree with that!

Summary: Who Better?
Rating: 5

I first read this book when it was first published, maybe 25 years ago. The book still holds up well all these years later, as it is a calm, rational history from the Center of the Cyclone (if I might borrow the title from Dr. John Lilly). Clearly, Dr. Hoffman was no stranger to realms of what many these days call entheogens, often experimenting himself with other "new" substances he discovered in other organic plants that found their way to him as a result of his monumental inadvertant destiny in "discovering" LSD. While some of the other substances he writes on were very new at the time, and therefore might read a little dated, on the whole, there is no one better qualified or in a better position to tackle such a significant topic.

Summary: problem children can do great things
Rating: 5

an elegant and substantive discourse on the curious ways in which science has coalesced with spirituality through the last several decades. This man’s mind is truly unique and his monumental discoveries, combined with his spectacular longevity and health, command respect.

Publish a great book and give all the proceeds to a worthwhile cause: you cannot go wrong here.

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Nanotechnology in Drug Delivery (Biotechnology: Pharmaceutical Aspects)
by: Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon

Nanotechnology in Drug Delivery (Biotechnology: Pharmaceutical Aspects)
By Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon

Publisher: Springer
Number Of Pages: 662
Publication Date: 2008-10-27
ISBN-10 / ASIN: 0387776672
ISBN-13 / EAN: 9780387776675

Product Description:

The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

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Handbook of Drug-Eluting Stents
by: Patrick W. Serruys, Anthony H. Gershlick
en | Informa HealthCare

1841841323 9781841841328 9780203640265

Handbook of Drug-Eluting Stents
By Patrick W. Serruys, Anthony H. Gershlick

Publisher: Informa HealthCare
Number Of Pages: 336
Publication Date: 2005-06-14
ISBN-10 / ASIN: 1841841323
ISBN-13 / EAN: 9781841841328

Product Description:

Over the past few years, the focus in interventional cardiology research has centered on reducing restenosis with the use of antiproliferative pharmacological agents. The use of these drugs, hitherto, has failed, most probably because of low active drug levels at the target site. This problem led to the development of local drug delivery using stents, since they can serve as a reservoir for local drug administration and are in immediate contract with the coronary artery wall, thus ensuring maximum delivery of the pharmacological agent. Drug-eluting stents provide an entirely new spectrum of potential therapies for restenosis. Handbook of Drug-Eluting Stents, under the editorial direction of Patrick Serruys, one of the world’s leading interventional cardiologists, and Tony Gershlick, a pioneer in the field of drug-eluting stents, provides the reader with up-to-date information on which stents and pharmacological agents in use or about to be launched, the kinetics of the drugs involved, and what the future may hold. Short Contents

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Saponins (Chemistry and Pharmacology of Natural Products)
by: K. Hostettmann, A. Marston
en | Cambridge University Press

9780521329705 0521329701 0521020174 9780521020176

Saponins (Chemistry and Pharmacology of Natural Products)
By K. Hostettmann, A. Marston

Publisher: Cambridge University Press
Number Of Pages: 560
Publication Date: 1995-05-26
ISBN-10 / ASIN: 0521329701
ISBN-13 / EAN: 9780521329705

Product Description:

This book is a timely incursion into the field and provides information about occurrence and distribution, structural types, isolation, analysis and structure determination of saponins. Biological and pharmacological activities are discussed, as are aspects of commerical and industrial use. Numerous examples are presented, providing a valuable source of data for the different classes of compound.

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Saponins (Chemistry and Pharmacology of Natural Products)
by: K. Hostettmann, A. Marston
en | Cambridge University Press

9780521329705 0521329701 0521020174 9780521020176

Saponins (Chemistry and Pharmacology of Natural Products)
By K. Hostettmann, A. Marston

Publisher: Cambridge University Press
Number Of Pages: 560
Publication Date: 1995-05-26
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Product Description:

This book is a timely incursion into the field and provides information about occurrence and distribution, structural types, isolation, analysis and structure determination of saponins. Biological and pharmacological activities are discussed, as are aspects of commerical and industrial use. Numerous examples are presented, providing a valuable source of data for the different classes of compound.

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