Metallothioneins in Biochemistry and Pathology
by: Paolo Zatta

Metallothioneins in Biochemistry and Pathology
By Paolo Zatta

Publisher: World Scientific Publishing Company
Number Of Pages: 336
Publication Date: 2008-10-15
ISBN-10 / ASIN: 9812778934
ISBN-13 / EAN: 9789812778932

Product Description:

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.

This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer’s and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Contents: Metallothionein in Neurological Disorders; Metallothionein in Oncology; Metallothionein in Cardiopathy; Metallothionein in Hepatology.

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Japanese Pharmacopeia (Pharmacopoeia of Japan) 15 Ed. 2006
by: Yakuji Nippo Ltd
en | Maruzen Company, Ltd.

4840809747 9784840809740

Japanese Pharmacopeia (Pharmacopoeia of Japan)
By Yakuji Nippo Ltd

Publisher: Maruzen Company, Ltd.
Number Of Pages: 1788
Publication Date: 2006-03
ISBN-10 / ASIN: 4840809747
ISBN-13 / EAN: 9784840809740

Product Description:

This is the English version of the 15th edition of the "Japanese Pharmacopoeia". It provides the official Japanese standard for the description and quality of drug substances and products. It contains over 1,300 articles regarding: general rules for preparations; processes and apparatus; monographs on drugs; and infrared reference spectra and ultraviolet-visible reference spectra.

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Outsourcing Clinical Development: Strategies for Working With CROs And Other Partners
by: Jane E. Winter, Jane Baguley

Outsourcing Clinical Development: Strategies for Working With CROs And Other Partners
By Jane E. Winter, Jane Baguley

Publisher: Gower Publishing Company
Number Of Pages: 170
Publication Date: 2006-01
ISBN-10 / ASIN: 0566086867
ISBN-13 / EAN: 9780566086861

Product Description:

The challenges facing large pharmaceutical companies are stark: sales are slowing and research and development costs are rising. There’s an overwhelming need to reduce development costs by as much as 30-40 per cent, whilst at the same time significantly shortening development cycle times. Pharmaceutical spend on outsourcing faces double-digit growth for the next three to five years and yet, if outsourcing is to meet these challenges, new models of collaborative and cooperative working are needed now. "Outsourcing Clinical Development" offers a guide to these new models and to future clinical outsourcing strategy. There is advice at a strategic level on the basis for an outsourcing strategy and how to work with CROs (clinical research outsourcers); geographical issues, such as low-cost environments. There’s also a detailed guide to selecting candidates, and managing the proposal, negotiation and contract process successfully; as well as reviewing the performance of your outsourcing and developing a strategic relationship in the longer term. The pharmaceutical outsourcing function is as complex and as influential a process as the clinical trials themselves. "Outsourcing Clinical Development", with a powerful mix of perceptive insight from leading lights in the industry, advice on long-term strategic direction and tools for immediate help is a must-have read for pharmaceutical companies and the CROs that support them.

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Forecasting for the Pharmaceutical Industry: Models for New Product And In-market Forecasting And How to Use Them
by: Arthur G., Ph.D. Cook

Forecasting for the Pharmaceutical Industry: Models for New Product And In-market Forecasting And How to Use Them
By Arthur G., Ph.D. Cook

Publisher: Gower Publishing Company
Number Of Pages: 141
Publication Date: 2006-11-18
ISBN-10 / ASIN: 0566086751
ISBN-13 / EAN: 9780566086755

Product Description:

In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month’s production schedule, to market estimates for drugs in the next decade. The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex ‘black box’ equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Art Cook’s highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. "Forecasting for the Pharmaceutical Industry" is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making.

Summary: Too simple
Rating: 2

If you do not know anything about forecasting techniques this is your book. The author give us a big picture about the main steps in the pharmaceutical industry forecasting. How ever if you already took an econometrics course or a business forecasting course this book it is not going to help you.

Summary: Nicely covers the broad areas of forecasting
Rating: 3

Nicely covers the broad areas of forecasting, and thats just what it does. It does not get in to the details. So if you are someone who wants to brush your knowledge then this is for you, but if you are looking to learn new methods then maybe you may want to look at some other options.

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Nanotherapeutics: Drug Delivery Concepts in Nanoscience
by: Alf Lamprecht

Nanotherapeutics: Drug Delivery Concepts in Nanoscience
By Alf Lamprecht

Publisher: Pan Stanford Publishing
Number Of Pages: 292
Publication Date: 2008-07-21
ISBN-10 / ASIN: 9814241024
ISBN-13 / EAN: 9789814241021

Product Description:

An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems allowing for innovative therapeutic approaches. Due to their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers, and intracellular drug delivery.

This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles,from duansci.com with each chapter discussing a specific disease (e.g. diabetes, cancer, inflammation, etc.) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. Written in a concise manner, readers will gain an insight into the basics of nanoparticle preparation as well as a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Contents: General Aspects of Nanotherapeutics: Nanocarriers in Drug Delivery - Design, Manufacture and Physicochemical Properties (C Schmidt & A Lamprecht); Transport Across Biological Barriers (N Nafee et al.); Targeting Approaches (S Cammas-Marion); Disease-Related Approaches by Nanotherapeutics: Nanoscale Cancer Therapeutics (Y Pellequer & A Lamprecht); Nanotherapeutics for Skin Diseases (N Atrux-Tallau et al.); Nanoparticles for Oral Vaccination (J M Irache et al.); Nanoparticles: Therapeutic Approaches for Bacterial Diseases (B Moulari); Nanoparticle Therapy in Parasites Diseases: Possibility and Reality! (M Larabi); Nanocarriers in the Therapy of Inflammatory Disease (A Lamprecht).

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Chemokine Receptors in Cancer (Cancer Drug Discovery and Development)
by: Amy M. Fulton

Chemokine Receptors in Cancer (Cancer Drug Discovery and Development)
By Amy M. Fulton

Publisher: Humana Press
Number Of Pages: 172
Publication Date: 2009-05-27
ISBN-10 / ASIN: 1603272666
ISBN-13 / EAN: 9781603272667

Product Description:

Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells.

Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.

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Drug Delivery Systems in Cancer Therapy (Cancer Drug Discovery and Development)
by: Dennis M. Brown

Drug Delivery Systems in Cancer Therapy (Cancer Drug Discovery and Development)
By Dennis M. Brown

Publisher: Humana Press
Number Of Pages: 400
Publication Date: 2003-11-15
ISBN-10 / ASIN: 0896038882
ISBN-13 / EAN: 9780896038882

Product Description:

Comprehensively reviews the drug delivery systems for cancer chemotherapy. Discusses the convention as well as the unconventional methods of drug administration and provides an overview of opportunities for future drug development. Focuses primarily on small molecule delivery. DNLM: Drug Delivery Systems–methods.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)
by: Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)
By Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

Publisher: Wiley
Number Of Pages: 480
Publication Date: 2009-07-27
ISBN-10 / ASIN: 0470227346
ISBN-13 / EAN: 9780470227343

Product Description:

This book gathers present knowledge on the involvement of ABC transporters in drug transport and resistance. Bringing together updated information from an otherwise-scattered field of scientific literature, this resource helps researchers in pharmaceutical science in discovering drugs able to counteract multidrug resistance in diseases like cancer. It examines ABC transporters not only at the cancer cell, but also in other important physiological localizations. This book covers these topics as well as the pharmaceutical and medicinal modulation and inhibition of ABC transporters, helping pharmaceutical researchers discover drugs to counteract multidrug resistance in diseases like cancer.

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Manufacturing of Pharmaceutical Proteins: From Technology to Economy
by: Stefan Behme

Manufacturing of Pharmaceutical Proteins: From Technology to Economy
By Stefan Behme

Publisher: Wiley-VCH
Number Of Pages: 404
Publication Date: 2009-03-16
ISBN-10 / ASIN: 3527324445
ISBN-13 / EAN: 9783527324446

Product Description:

This comprehensive introduction covers all aspects of biopharmaceutical manufacturing, including technology and facilities, GMP and regulatory issues, as well as costing and timeline aspects for supply chain implementation.

Written by a leading expert at one of the largest pharmaceutical companies worldwide, this practical text is aimed at a wide audience ranging from libraries, via biotech companies to students and technicians planning to enter biopharmaceutical manufacturing. In addition, it is well suited for academic teaching as well as internal training within larger biotech or pharmaceutical companies.

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New Bacterial Vaccines (Medical Intelligence Unit)
by: Ronald W. Ellis, Bernard R. Brodeur

New Bacterial Vaccines (Medical Intelligence Unit)
By Ronald W. Ellis, Bernard R. Brodeur

Publisher: Springer
Number Of Pages: 376
Publication Date: 2003-11-30
ISBN-10 / ASIN: 0306478323
ISBN-13 / EAN: 9780306478321

Product Description:

New Bacterial Vaccinesfocuses upon unfulfilled needs for bacterial vaccines. The increase in drug resistance among many bacterial species has increased the need for new bacterial vaccines. This book serves as a comprehensive reference on the major aspects of developing new bacterial vaccines. The distinctive feature of this book is that it focuses upon new vaccines now under development by reviewing key issues for each vaccine target and new technologies being applied to developing new vaccines. This book should prove useful for students in the life sciences, scientists, developers of vaccines and biotechnology products, clinicians, regulators, and health-care practitioners.

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Drug Toxicokinetics (Drug and Chemical Toxicology)
by: Welling
en | Informa HealthCare

0824790197 9780824790196 9780585399867

Drug Toxicokinetics (Drug and Chemical Toxicology)
By Welling

Publisher: Informa HealthCare
Number Of Pages: 432
Publication Date: 1993-05-13
ISBN-10 / ASIN: 0824790197
ISBN-13 / EAN: 9780824790196

Product Description:

This reference/text examines the importance of toxicokinetics on drug disposition and outlines its practical applications in drug development - helping readers incorporate the most up-to-date findings into their own work.;Consolidating research from international authorities in the fields of toxicology, pharmacokinetics, metabolism and biochemistry to illustrate the interdisciplinary nature of toxicokinetic situations, Drug Toxicokinetics: covers regulatory guidelines for conducting toxicokinetic studies to obtain maximum information for safety assessment and clinical use of drug candidates; illustrates the principles of linear and nonlinear pharmacokinetics and compares them to toxicokinetics; displays relationships between the time-span of drug concentrations in the body and the appearance of toxic effects; and spotlights problems and solutions regarding metabolism impact in toxicology as well as the bioactivation of drugs.;Containing over 950 literature citations, figures and tables, Drug Toxicokinetics is intended as a reference for pharmacists; organic and medicinal chemists; industrial, academic and government pharmacologists and toxicologists; pharmacokineticists; safety-evaluation scientists; pathologists and biochemists. It should also be a useful guide for personnel in public health, risk assessment, chemical industry, drug metabolism and drug regulatory affairs as well as for clinical and preclinical drug development scientists. The book should also serve as a useful text for upper-level undergraduate and graduate students in these disciplines.

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Pharmacy Case Studies
by: Soraya Dhillon, Rebekah Raymond

Pharmacy Case Studies
By Soraya Dhillon, Rebekah Raymond

Publisher: Pharmaceutical Press
Number Of Pages: 458
Publication Date: 2009-02-28
ISBN-10 / ASIN: 0853697248
ISBN-13 / EAN: 9780853697244

Product Description:

Whilst most pharmacy undergraduate texts are subject specific, "Pharmacy Case Studies" encourages students to take an integral approach to pharmacy via a series of pharmacy cases. Knowledge gained within the individual areas of law and ethics, pharmaceutics, pharmacology and pathology are tested by each example, bringing together all areas taught on the degree course. Each chapter contains five case studies, starting with uncomplicated cases and increasing in complexity as they expand.

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Martindale’s Drugs Restricted in Sport 2009 Pocket Companion
by: Sean Sweetman

Martindale’s Drugs Restricted in Sport 2009 Pocket Companion
By Sean Sweetman

Publisher: Pharmaceutical Press
Number Of Pages: 528
Publication Date: 2009-03-31
ISBN-10 / ASIN: 0853698708
ISBN-13 / EAN: 9780853698708

Product Description:

This is a unique guide to drugs restricted in sport. This is an A-Z guide by drug name (INN) of over 450 drugs restricted in sport. Each drug monograph has a regular structure containing a list of synonyms, drug profile (medical use), World Anti-Doping Agency (WADA) classification; restriction in sport (in and out of competition); and a list of single and multi-ingredient proprietary preparations containing the drug from 40 countries worldwide (Martindale data).

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British National Formulary 57: March 2009
by: Joint Formulary Committee

British National Formulary 57: March 2009
By Joint Formulary Committee

Publisher: Pharmaceutical Press
Number Of Pages: 978
Publication Date: 2009-04-02
ISBN-10 / ASIN: 0853698457
ISBN-13 / EAN: 9780853698456

Product Description:

This is the authoritative guide to prescribing, dispensing and administering medicines for all health care professionals. Nobody working in health care can afford to be without the latest edition of "BNF". Compiled with the advice of clinical experts and continually updated to reflect the latest evidence from all credible sources worldwide, this essential reference provides up-to-date guidance on prescribing, from duansci.com dispensing, administering, and monitoring medicines. Not only does the "BNF" include the widely accepted framework for the drug management of common diseases, it also includes details of medicines prescribed in the UK, with special reference to their uses, cautions, contraindications, side-effects, dosage and relative costs. This allows treatment to be tailored to the individual needs of each patient. Updated in print every six months by an expert team of pharmacists, with guidance and validation from a network of leading clinicians, and oversight by a Joint Formulary Committee with representatives from all spheres of clinical practice. "The BNF" reflects current best practice as well as legal and professional guidelines relating to the use of medicines. As a result it is used widely as a touchstone reference, and cited in Parliaments and courts as a source of authority. This title is available online as part of MedicinesComplete, on PDA and on CD-ROM for intranets.

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Physicochemical Principles of Pharmacy, 4th Edition
by: A. T. Florence, David Attwood

Physicochemical Principles of Pharmacy, 4th Edition
By A. T. Florence, David Attwood

Publisher: Pharmaceutical Press
Number Of Pages: 492
Publication Date: 2005-12-30
ISBN-10 / ASIN: 085369608X
ISBN-13 / EAN: 9780853696087

Product Description:

Physical chemistry is the basis of rational pharmaceutical formulation and processing, and is fundamental to understanding the complexities of drug delivery and drug absorption. This textbook presents the physiochemical principles useful to the modern pharmaceutical scientist and pharmacist.

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G Protein-Coupled Receptors in Drug Discovery (Methods in Molecular Biology, 552)
by: Wayne R. Leifert

G Protein-Coupled Receptors in Drug Discovery (Methods in Molecular Biology)
By Wayne R. Leifert

Publisher: Humana Press
Number Of Pages: 376
Publication Date: 2009-06-29
ISBN-10 / ASIN: 1603273166
ISBN-13 / EAN: 9781603273169

Product Description:

The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, experts in the field provide a range of classic and cutting-edge laboratory protocols developed for GPCR research, as well as several current review articles relevant to the area of high throughput GPCR screening, from duansci.com with discussion on GPCR structure and GPCR signalling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy to use, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols serves to aid all those who wish to further the vital research in their GPCR drug discovery programs.

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Davis’s Pocket Clinical Drug Reference
by: Shamim Tejani, PharmD, Cynthia Sanoski

Davis’s Pocket Clinical Drug Reference
By Shamim Tejani, PharmD, Cynthia Sanoski

Publisher: F A Davis Co
Number Of Pages: 225
Publication Date: 2009-02-28
ISBN-10 / ASIN: 0803620780
ISBN-13 / EAN: 9780803620780

Product Description:

Make sure your students rely on a trusted reference! This handy pocket guide shows them how to safely administer medications to their adult, pediatric, and geriatric patients, as well as pregnant and lactating women, and those with renal impairments.

Every detail is designed to make it easy for your students to find the information they need in a snap. And, they can count on it for accuracy because it s drawn from Davis s Drug Guide database.

OUTSTANDING FEATURES

*4 x 7 size fits in a scrub pocket.
*Nearly 1,000 abbreviated drug monographs, organized alphabetically by generic name, deliver must-know
information, including…
Trade name
Indications
Drug class
Pregnancy categories
Contraindications
Adverse drug reactions and side effects
Interactions
Dosing information for adult, pediatric, and geriatric patients, pregnant and lactating women, and renal impairment
Generic availability
Monitoring information
*Very important or life-threatening information, such as FDA black box warnings or adverse drug reactions, appears in red type.
*A colored thumb tab makes it easy for your students to find information quickly.
*The appendices features Cytochrome P450 enzyme table, Pediatric IV, immunization guidelines, and more.
*Abbreviations key appears in the front of the book and at the bottom of each page.*
Notes section covers patient safety information.
*Index provides generic and trade drug names.

Summary: Davis’s Drug Reference
Rating: 5

Super reference well structured and well written as a handy reference. Good for those at all levels who need rapid answers. Useful to for publishers to consider an online version.

eyedaktari

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Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2007
by: United Nations
en | United Nations

9211482259 9789211482256 9781435644151

Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2007
By United Nations

Publisher: United Nations
Number Of Pages: 92
Publication Date: 2008-05-03
ISBN-10 / ASIN: 9211482259
ISBN-13 / EAN: 9789211482256

Product Description:

To prevent the diversion of precursor chemicals for use in the illicit manufacture of drugs, governments must have adequate legislation in line with the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances as well as effective working mechanisms and procedures for information feedback between the authorities involved in the control of precursor chemicals. duansci.com The International Narcotics Control Board in its annual report examines actions taken recently and highlights both successful results and shortcomings.

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