Richard E Klabunde, “Cardiovascular Physiology Concepts”
Lippincott Williams & Wilkins; 1 edition | ISBN:078175030X | 256 pages | PDF | 5,6 Mb

This uniquely readable, compact, and concise monograph lays a foundation of knowledge of the underlying concepts of normal cardiovascular function. Students welcome the book’s broad overview as a practical partner or alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Especially clear explanations, ample illustrations, a helpful glossary of terms, tutorials, and chapter-opening learning objectives provide superb guidance for self-directed learning and help fill the gap in many of today’s abbreviated physiology blocks. A focus on well-established cardiovascular principles reflects recent, widely accepted cardiovascular research.

Download | Mirror

Proteolytic Enzymes: A Practical Approach
Oxford University Press, USA | 019963663X | Edition - 2001-03-15 | PDF |358 pages| 30.6 MB

Like the popular first edition, this new edition of Proteolytic Enzymes emphasizes practical aspects of the handling, characterization, inhibition, and use of proteolytic enzymes giving general advice and specific examples. The text and protocols have been thoroughly updated to take account of the advances made in the last 10 years in both the increased understanding of the role of peptidases in many critical cellular processes e.g. apoptosis and new technological developments e.g. in recombinant protein expression, protein sequencing, and structural studies. The topics covered are: nomenclature and classification; purification; assay methods; determination of mechanism; inhibition and prevention of unwanted proteolytic activity; characterizing natural inhibitors; proteolytic enzymes in peptide mapping and primary structure elucidation by mass spectrometry and Edman sequencing; limited proteolysis as a structural probe; synthetic function. This book will be as invaluable as the first edition in providing ideas and protocols for scientists either studying proteases or using proteases as a research tool.

Download | Mirror

Signal Transduction in Cancer (Cancer Treatment and Research)
Springer | 1402073402 | Edition - 2002-12-31 | PDF |336 pages| 6.4 MB

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously.
This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
Series Editor comments:
“The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets.”

Download | Mirror

Microbial Sulfur Metabolism
Springer | 3540726799 | Edition - 2007-10 | PDF |308 pages| 13.6 MB

In nature, sulfur occurs in many different oxidation states and is one of the most versatile elements in life. It is an integral part of many important cell constituents, such as the amino acids cysteine and methionine, and many sulfur compounds serve as the basis for energy-related processes in prokaryotes. In recent years, new methods have been applied to study the biochemistry and molecular biology of reactions of the global sulfur cycle, the microorganisms involved and their physiology, metabolism and ecology. These activities have uncovered fascinating new insights for the understanding of aerobic and anaerobic sulfur metabolism.

Download | Mirror

Guide to Analysis of DNA Microarray Data, Second Edition
John Wiley & Sons | 0471656046 | Edition - 2004 | PDF | 168 pages | 6.9 MB

Written for biologists and medical researchers who don’t have any special training in data analysis and statistics, Guide to Analysis of DNA Microarray Data, Second Edition begins where DNA array equipment leaves off: the image produced by the microarray. The text deals with the questions that arise starting at this point, providing an introduction to microarray technology, then moving on to image analysis, data analysis, cluster analysis, and beyond.
With all chapters rewritten, updated, and expanded to include the latest generation of technology and methods, Guide to Analysis of DNA Microarray Data, Second Edition offers practitioners reliable information using concrete examples and a clear, comprehensible style. This Second Edition features entirely new chapters on:
* Image analysis
* Experiment design
* Automated analysis, integrated analysis, and systems biology
* Interpretation of results
Intended for readers seeking practical applications, this text covers a broad spectrum of proven approaches in this rapidly growing technology. Additional features include further reading suggestions for each chapter, as well as a thorough review of available analysis software.

Download | Mirror

USB Mass Storage: Designing and Programming Devices and Embedded Hosts
Lakeview Research | ISBN: 1931448051 | 304 pages | 7/15/2006 | PDF | 1 Mb

This developer’s guide for designers and programmers of mass-storage devices that use the Universal Serial Bus (USB) interface provides developers with information on how to choose storage media, interface the media to a microcontroller or other CPU, and write device firmware to access the media and perform USB communications. Comparisons of popular storage-media options to help users choose a media type for a project are included, and the types described cover hard drives and flash-memory cards such as the MultiMediaCard (MMC), Secure Digital (SD) card, and CompactFlash card. Helpful tips on developing an embedded host that can access USB mass-storage devices are also covered.

Download | Mirror

Wireless Sensor Networks: Architectures and Protocols
CRC Press; 1 edition | ISBN: 0849318238 | 360 pages | August 26, 2003 | CHM | 8 Mb

Because they provide practical machine-to-machine communication at a very low cost, the popularity of wireless sensor networks is expected to skyrocket in the next few years, duplicating the recent explosion of wireless LANs. Wireless Sensor Networks: Architectures and Protocols describes how to build these networks, from the layers of the communication protocol through the design of network nodes. This overview summarizes the multiple applications of wireless sensor networks, then discusses network device design and the requirements that foster the successful performance of these applications. The book discusses factors affecting network design, including the partitioning of node functions into integrated circuits, low power system design, power sources, and the interaction between antenna selection and product design. It presents design techniques that improve electromagnetic compatibility and reduce damage from electrostatic discharge. The text also describes the design features of the wireless devices themselves, presenting a thorough analysis of the technology that engineers and students need to design and build the many future applications that will incorporate wireless sensor networks.

Download | Mirror

Jason Alan Jankovsky, “Trading Rules that Work: The 28 Lessons Every Trader Must Master”
Wiley (November 3, 2006) | ISBN:0471792160| 208 pages | PDF | 2,2 Mb

Trading Rules that Work introduces you to twenty-eight essential rules that can be shaped to fit any trading approach�whether you’re dealing in stocks, commodities, or currencies. Engaging and informative, Trading Rules that Work outlines the deeper psychology behind each of these accepted trading rules and provides you with a better understanding of how to make those rules work for you.

Download | Mirror

Kedrick Brown, “Trend Trading: Timing Market Tides”
Wiley (October 6, 2006) | ISBN:0471980218 | 219 pages | PDF | 3,5 Mb

Written in a straightforward and accessible style, Trend Trading teaches you how to trade equity trends with sound money management discipline, from the individual stock level to the whole portfolio level. Tailored to investors who want to use elements of trend following strategies in their equity portfolios, Trend Trading presents unique investment tools and advanced technical analysis methods in simple, commonsense terms.

Download | Mirror

Title: Dept of Army - M16A2 Rifle and M4 Carbine Operator
176 pages | August 1986 | PDF | 2.4 Mb

Book Description:

“MY RIFLE�

The creed of a United States Marine

by

Maj. Gen. W. H. Rupertus, USMC

This is my rifle. There are many like it, but this one is mine.
My rifle is my best friend. It is my life. I must master it as I must master my life.
My rifle, without me is useless. Without my rifle, I am useless. I must fire my rifle true. I must shoot
straighter than my enemy who is trying to kill me. I must shoot him before he shoots me. I will…
My rifle and myself know that what counts in this war is not the rounds we fire, the noise of our
burst, nor the smoke we make. We know that it is the hits that count. We will hit . . .
My rifle is human, even as I, because it is my life. Thus, I will learn it as a brother. I will learn its
weaknesses, its strength, its parts, its accessories, its sights, and its barrel. I will ever guard it
against the ravages of weather and damage. I will keep my rifle clean and ready, even as I am
clean and ready. We will become part of each other. We will …
Before God I swear this creed. My rifle and myself are the defenders of my country. We are the
masters of our enemy. We are the saviors of my life.
So be it, until victory is America’s and there is no enemy, but Peace!

Download:
http://rapidshare.com/files/64615282/M16A2-M4_Manuals.rar

Rick Riolo, Terence Soule , Bill Worzel, “Genetic Programming Theory and Practice IV (Genetic and Evolutionary Computation)”
Springer; 1 edition (March 2007) | ISBN:0387333754 | 338 pages | PDF | 17,7 Mb

Genetic Programming Theory and Practice IV was developed from the fourth workshop at the University of Michigan’s Center for the Study of Complex Systems to facilitate the exchange of ideas and information related to the rapidly advancing field of Genetic Programming (GP). Contributions from the foremost international researchers and practitioners in the GP arena examine the similarities and differences between theoretical and empirical results on real-world problems. The text explores the synergy between theory and practice, producing a comprehensive view of the state of the art in GP application.

This volume represents a watershed moment in the GP field in that GP has begun to move from hand-crafted software used primarily in academic research, to an engineering methodology applied to commercial applications. It is a unique and indispensable tool for academics, researchers and industry professionals involved in GP, evolutionary computation, machine learning and artificial intelligence.

Download:
http://depositfiles.com/files/2139721

Geek Squad Manuals - Leaked
6 PDFs | 7.4 MB | BURN OR EAT THIS DOCUMENT AFTER READING

Description:

-Camcorder Training
-CIA Handbook
-Double Agent Handbook
-Data Backup Checklist
-Voip Training
-Wifi Leave Behind

Download:
http://rapidshare.com/files/64673270/6geeksquadmanuals.rar

Treatment of the Obese Patient (Contemporary Endocrinology) by Robert F. Kushner, Daniel H. Bessesen
Humana Press | 2007-05-08 | 1588297357 | PDF | 444 p | 7.2 Mb

Treatment of the Obese Patient is a timely and informative text for all health care providers challenged with helping patients manage weight. This volume includes insight into recent scientific advances in obesity research and provides the most up-to-date reviews of current treatment issues and strategies.

The volume is divided into two parts. Part I covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Expert authors discuss pathways that control food intake, energy expenditure, and peripheral nutrient metabolism, including a look at the emerging evidence of the role of adipose tissue as an endocrine organ. Part 2 covers issues central to clinical management. Authors in this section discuss polycystic ovarian syndrome, diabetes, energy density, glycemic index, low-carbohydrate diets, the role of physical activity, and novel approaches to pharmacotherapy, surgery, and management of micronutrient deficiencies in the postbariatric patient. An essential, practical text that sorts, synthesizes, and interprets the latest information on obesity-related topics, Treatment of the Obese Patient is an essential volume for clinical endocrinologists and other health care providers.

Download:
http://rapidshare.com/files/64720539/TreatmentoftheObesePatient.pdf

Growing Bone by James F. Whitfield
Institute for Biological Sciences of Canada | ISBN: 9781587061561 | 2007-10-1 | PDF | 273 p | 3 Mb

TOC
Strontium, Calcium’s Big Brother

James F. Whitfield

Strontium (Sr) has been very recently hyped as the latest “paradigm-changingâ€Â? thing in the treatmen of osteoporosis as indicated by the title of a paper by Reginster et al (2003)â€â€?“Strontium Ranelate: A New paradigm for the treatment of Osteoporosisâ€Â?. When two atoms of strontium combine with ranelic …
Surface Signaling Steroids�Real Anabolics or Pseudo-Anabolics?

James F. Whitfield

In 1998 Sicinski et al reported the synthesis of new 1a, 25-(OH)2-19-nor-vitamin D3 analogs such as 2MD (2-methylene-19-nor-(20S)-1a,25(OH)2D3) which are super-potent derivatives of the natural 1a, 25-(OH)2-vitamin D3. Four years later Shevde et al. (2002) reported that 2MD is a far more potent stim…
The Statins

James F. Whitfield

While the PTHs are by far the leading anabolic agents for treating osteoporosis and mending fractures, another family of drugs has been trying to challenge them but with very mixed results (Mundy, 2000; Whitfield, 2001, 2002a). These now old drugs were discovered by Endo and colleagues during a sear…
OGP�The Osteogenic Growth Peptide

James F. Whitfield

Scooping out the marrow or driving a nail into the marrow cavity of a bone such as the tibia, like a fracture, causes the marrow cavity to fill with a blood clot and releases a shower of osteogenic signalers such as b2-microglobulin, IGF-I, PDGF, TGF-bs, and VEGF from platelets, shocked bone-lining …
The Clinical Prospects of the Invincible PTHs

James F. Whitfield

The osteoporosis market is a rapidly growing “marketer’sâ€Â? dream. And several years ago there was no known bone-growing drugâ€â€?only the ever-worrisome (for cancerophobics) estrogens and the other antiresorptives. So the marketeers at Eli Lilly decided that the old hPTH-(1-34) would be the ideal drug wi…
How Might PTHs Stimulate Bone Growth?

James F. Whitfield

To tackle the formidable job of understanding how the PTHs stimulate bone growth in humans, rodents and other animals (Fig. 17) we must know where and how things start. What signals do they send into their target cells via the PTHR1 receptors to trigger osteogenesis? However, before going on I must…
The Amazing Bone-Anabolic PTHs

James F. Whitfield

Clearly the antiresorptives are far from being the ‘Holy Grails’ of osteoporosis therapy although they do break the vicious cyle of escalating remodeling and microdamage (Fig. 10). Since by the time of their first fracture, the bones of osteoporotic postmenopausal women have undergone considerable m…
Menopause and Bone Loss

James F. Whitfield

So far it has seemed that estrogen is the primus inter pares of an ever-growing number of agents that control bone growth and strength in both women and, perhaps surprisingly, men (Baylink et al, 1999; Klein, 1999; Stevenson and Lindsay, 1999; Vanderschueren et al., 2000). Now it appears that bones …
BMUS�The Microcrack Fixers

James F. Whitfield

At first sight bones are inert, rock-like things that store 99% of the body’s calcium and consist of a hard shell, the cortex, that encloses a deceptively delicate lattice of struts and plates (Jee, 2001) (Fig. 1).The cortex is made of hard, 5%-10% porous, calcified armor plate with embedded cells c…
What Is Osteoporosis?

James F. Whitfield

Osteoporotic postmenopausal women don’t need to fall or hit something to break their fragile bones. Their, hips, ribs, wrists and especially vertebrae are apt to be broken or crushed by bending spines, muscle pullings and the low-impact bumps of ordinary daily activities. In fact the greatest bone b…

Download:
http://rapidshare.com/files/64721093/GrowingBone.rar
Password:
avaxhome

Immunobiology of Natural Killer Cell Receptors (Current Topics in Microbiology and Immunology)
Springer | 3540260838 | Edition - 2005-12-01 | PDF |286 pages| 2.4 MB |

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Download:
http://rapidshare.com/files/62697064/Immunobiology_of_Natural_Killer_Cell_Receptors.rar

Interleukin-10
Landes Bioscience, Inc | 1587062852 | Edition - 2006-01-26 | PDF | 206 pages | 2.4 MB

Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregate propulsions in high and low producers. Surprisingly, high IL-10 producers may be more predisposed to acquire cancer and other diseases. Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. Thus, there exists a compelling need to summarize in a book the state of the science of this important cytokine. With the assistance of several experts in this field, Interleukin-10 has attempted this endeavor.

Download:
http://rapidshare.com/files/62695146/Interleukin-10.rar