Long-Range Control of Gene Expression
Publisher: Academic Press | English | ISBN:0123738814 | 416 pages | Data: 2008 | PDF | 4 Mb
Description: This volume covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. * Includes information on aspergillus genomes * Discusses sex and its role in virulence of human fungal pathogens * Covers the genomic analysis of neurospora
What constitutes long-range control is, by its nature, difficult to define. InDrosophila, cis-acting long-range elements located at a distance of a kilobase or so from the target gene’s promoter are considered to be operating at a long distance. On the other hand, in mammals the classic long-range element is the locus control region (LCR) of the beta-globin locus, sitting 50kb from the globin gene cluster. We now know that cis-regulatory elements can lie at a distance of at least a megabase, but the absolute distance that regulators are able to span to control gene expression is unknown. The properties that dictate these regulatory limits are still open to investigation. But no matter the distance, the goal is the same; that is, to convey regulatory information across an intervening stretch of DNA to control target gene expression. Although some aspects of
regulatory control have been known for three quarters of a century, the recent availability of multiple genomic sequences and high-throughput technologies has generated an emerging view of regulatory mechanisms. In this volume, we cover some of the most recent advances in this fast-moving area of genomic mechanisms involved in gene regulation.
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