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Encyclopedia of Immunology (4-Volume Set)
Academic Press | ISBN: 0122267656 | Second Edition - July 15, 1998 | PDF | 3072 pages | 199 MB
With more than 700 expert authors from 22 different countries, the Encyclopedia of Immunology, Second Edition is the largest comprehensive reference source of current immunological knowledge available. It provides a broad scope and high level of expertise to the many aspects of the field of immunology and related areas, including microbiology, virology, and parasitology. Arranged into 31 subject areas with extensive cross-referencing and subject indexes in each volume, the Encyclopedia is easy-to-use for virtually any researcher, regardless of his or her field. Concise definitions of the subject area also introduce each entry. The Second Edition includes timely and thorough updates for all articles from the First Edition, more than 60 new entries, a glossary of immunological terms in each volume, a total of 500 figures and tables, and new color plates sections.

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Praise for the First Edition:

"... undoubtedly provides the largest comprehensive source of immunological knowledge available...The Encyclopedia of Immunology is an essential text for any biomedical
department, hospital, or university library."
--IMMUNOLOGY TODAY

"Certainly these three volumes belong on the bookshelf of anyone working in the field"
--NATURE
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Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids
Springer | ISBN:3540665730 | Edition - April 26, 2000 | PDF | 247 pages | 3 MB
This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.

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Inulin-Type Fructans: Functional Food Ingredients (Modern Nutrition)
CRC Press | ISBN: 0849300592 | 2004-10-28 | PDF | 392 pages | 4.23 Mb | RS
Inulin and oligofructose are naturally occurring resistant carbohydrates that have a variety of uses as functional food ingredients. In addition to their role as prebiotics that selectively stimulate the growth of beneficial bacteria in the intestines, these inulin-type fructans act as dietary fiber in the digestive system and have applications as a sugar substitute and fat replacer. Written by one of the leading researchers in the field, Inulin-Type Fructans: Functional Food Ingredients describes inulin-type fructans and explains how they can be analyzed, quantified, and used in a wide variety of food products. The text evaluates the nutritional properties of inulin-type fructans, focusing on their behavior in the upper gastrointestinal tract that have led to their classification as dietary fiber and low calorie carbohydrates. Following a review of the selective and beneficial modification of the intestinal microflora that led to the discovery of prebiotics, the book concentrates on the relationship of inulin and oligofructose to lipid metabolism, carcinogenesis, mineral absorption, and the immune system. The text concludes with a general discussion of the classification of inulin-type fructans as functional food ingredients. Each chapter begins with background information on the physiology and biochemistry of the particular function covered as well as on the methodology used to assess these functions, and concludes with a summary of the results and perspectives on future development. The combination of authoritative research data and insightful perspectives provides a comprehensive overview of this growing field.
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Vitreous Microsurgery
Pages: 278 | Date: 2006 | ISBN: 0781764432 | Rared CHM File | Rapidshare & Depositfiles | 20 MB

Written by a pioneering leader in the development of vitreoretinal surgical techniques and instruments, this volume is a comprehensive how-to guide to all vitreoretinal procedures. This thoroughly updated Fourth Edition describes many new techniques and refinements of established procedures. More than 160 three-dimensional full-color illustrations--many by the Charles Retina Institute's resident medical artist, Byron Wood--enable surgeons to clearly visualize the techniques. This edition features a brand-new chapter on small diameter (25-gauge) sutureless transconjunctival vitrectomy, and presents state-of-the-art information on anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Other highlights include new information on intravitreal Kenalog and new strategies for managing retinopathy of prematurity.

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R. Douglas Collins ,"Differential Diagnosis in Primary Care"
Publisher:Lippincott Williams & Wilkins | Pages:528 | 2007-08-01 | ISBN:0781768128 | CHM | 54.57 MB
This text offers students, residents, and practitioners a systematic approach to differential diagnosis of symptoms and signs seen by primary care physicians. The text is organized by symptoms and signs into categories--pain, mass, bloody discharge, non-bloody discharge, functional changes, and abnormal laboratory results. It shows readers how to use their basic science knowledge to identify the possible causes of each symptom, and describes the procedures and laboratory tests that need to be included in the workup. This edition includes fifty new signs and symptoms, case histories for approximately ninety common symptoms and signs, and updated information on current diagnostic procedures.

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G. Lyman, H. Burstein"Breast Cancer - Translational Therapeutic Strategies"
Informa, 2007 | ISBN: 0849374162 | English | PDF | 344p.
Considering the impact of translational breakthroughs on the early detection, diagnosis, prevention, and treatment of breast cancer, this all-encompassing guide collects cutting-edge research on the most promising strategies and agents likely to impact the management and long-term outcomes of women with breast cancer. This book will provide current information on rapidly evolving translational therapies, as well as improved strategies for the selection of patients for these treatments.

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Adoptive Immunotherapy - Methods and Protocols - B. Ludewig, M. Hoffmann
Humana, 2005 | ISBN:1592598625 | English | PDF | 517 p | 6.7 MB
An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy.

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Computational Methods in Systems Biology
Springer | 3540751394 | Edition - 2007-10 | PDF | 249 pages | 9.36MB | rapidshare
This book constitutes the refereed proceedings of the International Conference on Computational Methods in Systems Biology, CMSB 2007, held in Edinburgh, Scotland, September 20-21, 2007. The 16 revised full papers presented were carefully reviewed and selected. The papers present a variety of techniques from computer science, such as language design, concurrency theory, software engineering, and formal methods, for biologists, physicists, and mathematicians interested in the systems-level understanding of cellular processes.

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Chandra M. Kumar, Mark Bellamy, "Gastrointestinal and Colorectal Anesthesia "
Publisher:Informa Healthcare | Pages: 456 | 2006-09-18 | ISBN: 084934073X | PDF | 2.72 MB
This resource stands as the only authoritative text to specifically focus on developments and best practices in anesthesiology for procedures affecting the gastrointestinal tract and related appendages. This book provides in-depth coverage of topics such as risk assessment, stress response, and scoring, as well as spans anesthetic trends and practices for endoscopic and laparoscopic procedures, as well as a variety of invasive procedures including hepatobiliary, pancreatic, colorectal, colonic, and abdominal surgeries.

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The Biochemistry of Cell Signalling
Oxford University Press | 0198508204 | Edition - August 20, 2001 | DJVU | 386 pages | 5 MB
The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ss in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response. As phosphorylation - dephosphorylation is involved in nearly all cellular regulatory processes, Part 1 concludes with a synopsis of its role in signalling. Part 2 describes the implementation of the signalling cascades focusing on the effect on gene transcription. After a brief description of the transcriptional machinery the regulation of transcription by cytokines and growth factors in the control of cell growth and the mechanisms and sites of control are discussed in detail. The regulators discussed include Jun/Fos, NF-AT, SREBPs, and STATs. The next two chapters cover gene regulation by nuclear receptors, including both the steroid hormone receptors and non-steroid nuclear receptors e.g. the retinoic acid receptors RAR and RXR. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. The first chapter concerns the regulation of the cell cycle and the role of the cyclin-dependent kinases, telomerase, Ran, and cell cycle checkpoints. The next topic is the signalling pathways in apoptosis: the TNF-receptor family death receptors, caspases, and the intracellular apoptosis signals and the role of apoptosis in the lifecycle of cells. Part 3 ends with a discussion of the signal pathways involved in the immune response, focusing on the involvement of cell-cell interactions. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer. It first describes the cellular regulatory proteins that have oncogenic potential, how they can become oncogenic and cause the transformation of normal cells to cancerous cells. Next is an analysis of the loss of developmental controls, the APC protein, ss-catenin, and the Wnt pathway, that lead to mature terminally differentiated cells reverting to immature embryonic cells. The book ends with a summary of the molecular and cellular causes of cancer and an outlook for novel therapies. Throughout the text, the emphasis is on structure and mechanism and is well illustrated with 200 figures. The Biochemistry of Cell Signalling will be an invaluable companion to all graduate students studying cell signalling.

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Biotechnological Applications of Photosynthetic Proteins: Biochips, Biosensors and Biodevices
Springer | ISBN: 0387330097 | Edition - 2006-06-09 | PDF | 218 pages | 14.1MB | rapidshare
Biotechnological Applications of Photosynthetic Proteins: Biochips, Biosensors and Biodevices provides an overview of the recent photosystem II research and the systems available for the bioassay of pollutants using biosensors that are based on the photochemical activity. The data presented in this book serves as a basis for the development of a commercial biosensor for use in rapid pre-screening analyses of photosystem II pollutants, minimising costly and time-consuming laboratory analyses.

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Primer of Biostatistics 5th Edition
McGraw-Hill | ISBN: 0071379460 | 5 Edition - November 5, 2001 | PDF | 489 pages | 13 MB
You'll start with the basics, including analysis of variance and the t test, then advance to a multiple comparison testing, contingency tables, regression, and more. Examples from the current literature illustrate key concepts throughout.

New:
* More on multiple comparison testing, including the Holm test
* Discussion of relative risks and odds ratios
* Updated examples from the literature

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"Color Atlas Of Forensic Pathology"
Publisher:CRC | Pages:192 | 1999-12-21 | ISBN:0849302781 | PDF | 29.8 MB
This extensive atlas addresses much of the basic information which forensic pathologists and other investigators deal with on a day to day basis. Packed with 800 full-color, captioned photographs, it examines everything from time of death and decomposition, to identification, blunt trauma, sudden natural death, firearm injuries, asphyxia, cutting and stabbing injuries, and more. The atlas shows different causes of death and injury with case examples for investigators who can use 'visuals' to understand the work they perform.

A male homicide victim with a shotgun blast to the chest. A female drug addict who has overdosed on crack cocaine. An elderly woman with deep stab wounds to the neck. A two-year-old motor vehicle accident victim with blunt head trauma. For forensic pathologists, police detectives, and crime scene investigators, dealing with death and injury is a daily routine. But even after investigating thousands of drownings, shootings, stabbings, electrocutions, overdoses, and traffic accidents, most professionals in the investigative fields still haven't seen it all. Originally published on CD-ROM, the Color Atlas of Forensic Pathology addresses much of the basic information which forensic pathologists and other investigators deal with on a day to day basis. Packed with 780 full-color, captioned photographs, this atlas examines everything from time of death and decomposition, to identification, to causes of death from blunt trauma, firearm injuries, asphyxia, cutting and stabbing injuries, and more. The atlas shows the various causes of death and injury with case -- "visuals" to help investigators understand the work they perform. Indeed, with its exhaustive coverage, the Color Atlas of Forensic Pathology will provide investigators with valuable insight into the many different causes of death and injury they must deal with and how the manners of death are diagnosed.

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Introductory Biostatistics for the Health Sciences: Modern Applications Including Bootstrap
Wiley-Interscience | ISBN: 047141137X | Edition - March 17, 2003 | PDF | 424 pages | 7.3 MB
".readers will come away with a better understanding of biostatistics..." (Statistical Methods in Medical Research, Vol.14, No.1, 2005)

".a good textbook for an introductory course in biostatistics at the advanced undergraduate/beginning graduate level.covers a broader variety of topics that is usually found in comparable textbooks." (The American Statistician, Vol. 58, No. 2, May 2004)

"...lucid writing style and numerous real-world examples add to the book's appeal and value...complex subject uniquely accessible..." (Zentralblatt Math, Vol. 1028, 2004)

"...the authors' lucid writing style and numerous interesting real-world examples make a complex subject quite acc3essible to a diverse audience...I recommend this book to undergraduate statistics students, medical personnel, public health trainees, or nursing and medical students...would also make an excellent textbook for an introductory...biostatistics course." (Mathematical Reviews, Issue 2004b)

"...the book is most successful in meeting the needs of students..."

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Improving the Fat Content of Foods
CRC Press | ISBN: 084939208X | 2006-03-03 | PDF | 542 pages | 4.18 Mb | RS
As health problems such as obesity, diabetes, and heart disease increase world wide, the food industry has come under fire to improve the nutritional quality of its products, especially the fat content. Summarizing key research, this collection examines both the influence of dietary fats on health and practical strategies for improving the fat content of food. Distinguished editors and an international team of contributors, review the evidence on the links between dietary fats and health. They discuss ways of reducing saturated fatty acids in food, explore how to develop and use PUFAs as functional ingredients, and cover ways of improving the sensory quality of product incorporating modified fats.

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Leslie Klenerman,"The Tourniquet Manual - Principles and Practice "
Publisher:Springer | Pages: 106 | 2003-07-30 | ISBN: 1852337060 | PDF | 1.86 MB
The Tourniquet Manual - principles and practice provides a comprehensive and detailed account of the safe use of the tourniquet by using a physiological approach which ensures good practice. Starting from a historical background the reader learns the detailed effects of ischaemia on the vulnerable tissues, especially muscle and nerve. The effects of releasing the tourniquet on the systemic circulation and the complicated biochemistry of the ischaemia-reperfusion response are explained. Complications and good practice are discussed. There is a chapter on the latest technological advances in tourniquets. This book provides a coherent account of the subject and is an invaluable source of references. It will help avoid medicolegal problems and promote good practice by surgeons, anaesthetists and operation theatre technicians alike and should be in every theatre office.

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Manual of Gastroenterology: Diagnosis and Therapy, 3rd Edition
Author: Canan Avunduk | Publisher: Lippincott Williams & Wilkins | ISBN:0781733626 | 3rd ed. 2002 | chm, 505 pages | language: english | 5 MB
Practical quick-reference guide to the dianosis and treatment of all gastrointestinal problems. Thoroughly revised and updated for its Third Edition, this addresses everything from common complaints such as intestinal gas to life-threatening diseases such as cancer and AIDS. Chapters written in an easy-to-scan outline format cover the approach to the patient, diagnostic and therapeutic procedures, nutrition, gastrointestinal emergencies, and specific symptoms and diseases. Drug information has been expanded throughout the manual. Find completely re-worked chapters on reflux disease, irritable bowel syndrome, peptic ulcer, inflammatory bowel disease, and viral hepatitis. Learn about significant recent changes in drugs and treatment modalities.

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Immunology of Fungal Infections
Springer | ISBN:1402054912 | Edition - January 2007 | PDF | 500 pages | 3.9 MB
The immunology of fungal infections is a comprehensive text covering all aspects of the immunology of infection with fungal pathogens. In addition to established knowledge, this book covers recent developments in the innate and adaptive immunological mechanisms involved in the host response to fungal infection. The volume is divided into a number of sections, which provide an immunological perspective on the cells, soluble factors and receptors involved in recognising and combating fungal pathogens. Further sections provide detailed descriptions of immunity to specific fungi, immune-escape mechanisms used by these organisms and immune-based therapeutic strategies. This book would be a valuable resource for those interested in fungal immunology particularly, students, specialists, teachers, researchers and clinicians.

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Using Mass Spectrometry for Drug Metabolism Studies
CRC Press | ISBN: 0849319633 | 2004-12-17 | PDF | 370 pages | 10.0 Mb | RS
Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field. Using Mass Spectrometry for Drug Metabolism Studies is an excellent resource for professionals in the fields of mass spectrometry and drug metabolism. It offers current knowledge in stand-alone chapters that address specific topics thoroughly enough to be read independently, with notes and references to other chapters for further reading. The first eight chapters discuss current topics regarding the use of MS for analyzing various types of in vitro and in vivo drug metabolism samples and the final four chapters describe the latest MS technology and its uses. In each chapter, expert authors demonstrate how to apply MS to determine drug metabolism parameters. They also explain the different drug metabolism concepts and their importance. Although there are a few books currently on the market that address this topic, they are rapidly becoming out-of-date. This book gives drug researchers and pharmacokineticists the latest information available on this important technology.
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Weiner's Pain Management: A Practical Guide for Clinicians
Pages:1612 | Date:2005 | ISBN:0849322626 | Rared PDF File | Rapidshare & Depositfiles | 12 MB

This latest edition of the best-selling Weiner's Pain Management: a Practical Guide for Clinicians features updated chapters, broad revisions, and over fifty new contributions. It offers an interdisciplinary approach to pain management and delivers a scholarly presentation for professionals concerned with pedagogy while still being accessible to those more concerned with applications. The book offers both traditional and alternative approaches to diagnosing, treating, and managing pain for adults as well as children and geriatric patients, all updated to reflect the most recent developments in pain management.

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Immunoinformatics: Predicting Immunogenicity In Silico
Humana Press | ISBN: 1588296997 | Edition - June 21, 2007 | PDF | 416 pages | 12.8 MB
Immunoinformatics: Predicting Immunogenicity In Silico is a primer for researchers interested in this emerging and exciting technology and provides examples in the major areas within the field of immunoinformatics. This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology.

The volume is conveniently divided into four sections. The first section, Databases, details various immunoinformatic databases, including IMGT/HLA, IPD, and SYEPEITHI. In the second section, Defining HLA Supertypes, authors discuss supertypes of GRID/CPCA and hierarchical clustering methods, Hla-Ad supertypes, MHC supertypes, and Class I Hla Alleles. The third section, Predicting Peptide-MCH Binding, includes discussions of MCH binders, T-Cell epitopes, Class I and II Mouse Major Histocompatibility, and HLA-peptide binding. Within the fourth section, Predicting Other Properties of Immune Systems, investigators outline TAP binding, B-cell epitopes, MHC similarities, and predicting virulence factors of immunological interest.

Immunoinformatics: Predicting Immunogenicity In Silico merges skill sets of the lab-based and the computer-based science professional into one easy-to-use, insightful volume.

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Vascular Mechanics and Pathology
Pages: 494 | Date: 2007 | ISBN: 0387338163 | Rared DAA (Power ISO) File | Rapidshare & Depositfiles | 40 MB
The book focuses on the artery and arterial diseases. The most fundamental functions of the artery are (1) to serve as a conduit of blood flow and (2) to serve as a container of blood pressure. The artery carries the blood to all organs of the body and it uses pressure to drive the blood through the tissue to provide nourishment. Hence, the artery is both a pipe and a pressure vessel. The artery pulsates about 103,000 times a day along with the beating heart. In a lifetime, the artery sustains cyclic pressure for about 3.8 billion cycles. This obviously poses a significant challenge to the artery and therefore the artery must be endowed with special structure and properties to meet this challenge. In the event that additional challenges are imposed, such as high blood pressure, it would not be surprising that the artery could "break down" or become diseased. In the book, we examine the structure and properties of the artery and study the challenges imposed on it with a view to understand the survival of and the development of the diseases in the artery.

The book will be useful to cardiovascular surgeons, cardiologists, pathologists, radiologists, neurosurgeons, anatomists, and manufacturers of medical devices. It will also be useful to students in medicine and in biomedical engineering and to the researchers in various disciplines. It can serve as "the book" for a course on "vascular mechanics and pathology" in bioengineering. It is likely to open new doors for interdisciplinary research, which could lead to the reduction of vascular diseases and to the development of new treatments, thereby benefiting large number of patients.

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Transcription Factors - Normal and Malignant Development of Blood Cells - K. Ravid, J. Licht
Wiley, 2001 | ISBN: 0471350540 | English | PDF | 640p. | 11 MB
Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias

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