January 17 2008 (Vol.451 Issue.7176) | English | PDF | 24.9MB
Cover: Cancer stem cells have been isolated from a number of human tumours. The hybrid melanoma cell shown on the cover, depicted as a merged, computer-enhanced fluorescent microscopy image, arose in vivo in a human tumour xenograft through fusion of an ABCB5+ melanoma stem cell with a more differentiated, ABCB5- tumour cell. Nuclei are marked by genetically encoded red (DsRed) and green (EYFP) fluorescent labels, respectively.
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