Amphetamine Syntheses Overview & Reference Guide for Professionals (Revised Industrial Edition)
by: Otto Snow

Amphetamine Syntheses: Industrial
By Otto Snow

Product Description:

Amphetamine Syntheses (1998) was a global blockbuster. The new and improved Industrial edition is now available, jam packed with state of the art drug chemistry, hot new formulas written by some of the greatest minds of the 20th century. Small town mom and pop labs across America to the multi-ton labs of global organized crime, how they make drugs and what they use to make them.

Otto has put together the most explicit syntheses on the bulk production of psychedelic amphetamines, precursors and reductions. MDA, MDMA (XTC), DOB, TMA, PMA, MDEA (Eve), DOM (STP) & other popular stimulants, eg. methylcathinone, phenetermine, aminorex, ephedrine. It is easy reading yet, explicit, hardcore, psychedelic amphetamine chemistry. eg. Methylcathinone and other psycho-stimulants from non-list chemicals. Production of precursors from fertilizer, spices, barks, seeds and oils. Expanded metal & electrolytic reductions. Bulk production of reduction & list chemicals from solvents & common chemicals at the local hardware store. Hundreds of reactions are described, current drug laws and list chemicals.

400 references.

UV Laminated, index

AMAZON DESCRIPTION

Amphetamine Syntheses: Industrial (Paperback)
by Otto Snow

Product Details
Paperback: 256 pages
Publisher: Thoth Press; Revised edition (September 2002)
Language: English
ISBN-10: 096631283X
ISBN-13: 978-0966312836

Editorial Reviews Review
Amphetamine Syntheses is an excellent introduction into the sometimes murky world of the illegal and clandestine drug manufacturing… The book’s main intent is to address the problem of the independent neuro-chemist, caught in professional and political crossfire from the war on drugs. — Thomas Lyttle, author of Psychedelics ReImagined, Psychedelic Monographs & Essays, Vols. 1-6

As a past member of the New Jersey Narcotic Enforcement Officers Association, who also served on their board of directors, I highly recommend your new book to all my brother and sister officers throughout the country. — Gregory F. Lennon, Captain of Police, Ret., Little Egg Harbor Twp., New Jersey

Tremendous! …easy to read and understand. …a must have for lawyers, police officers, chemists, counselors and anyone else working in or on the fringes of psychoactives. — James R. Young, Ph.D., Forensic Chemist, Bangor Maine

Product Description
Amphetamine Syntheses (1998) was a global blockbuster. The new and improved Industrial edition is now available, jam packed with state of the art drug chemistry, hot new formulas written by some of the greatest minds of the 20th century. Small town mom and pop labs across America to the multi-ton labs of global organized crime, how they make drugs and what they use to make them. Otto has put together the most explicit syntheses on the bulk production of psychedelic amphetamines, precursors and reductions. MDA, MDMA (XTC), DOB, TMA, PMA, MDEA (Eve), DOM (STP) & other popular stimulants, eg. methylcathinone, phenetermine, aminorex, ephedrine. It is easy reading yet, explicit, hardcore, psychedelic amphetamine chemistry. eg. Methylcathinone and other psycho-stimulants from non-list chemicals. Production of precursors from fertilizer, spices, barks, seeds and oils. Expanded metal & electrolytic reductions. Bulk production of reduction & list chemicals from solvents & common chemicals at the local hardware store. Hundreds of reactions are described, current drug laws and list chemicals. 400 references. UV Laminated, index

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• Amphetamine Syntheses Overview Reference Guide for Professionals (Psychoactive Synthesis Series Vol 1)

Amphetamine Syntheses Overview & Reference Guide for Professionals (Psychoactive Synthesis Series Vol 1)
by: Otto Snow

Amphetamine Syntheses Overview & Reference Guide for Professionals
By Otto Snow

Product Description:

the most comprehensive reference guide on the syntheses of amphetamines, phenyethylamines, ephedrine, cathinone, their immediate precursors and precursors. This includes the syntheses of mescaline and all popular psychedelic amphetamines including MDMA, MDEA, 2CB, TMA, DOB, DOM etc.

Hundreds of reactions are described including a review of the Controlled Substance Analogue Act. Many of the reactions include: Reductions of phenyl-2-propanone using aluminum amalgam, aluminum turnings or aluminum foil. The preparation of aluminum amalgam, mercury bichloride. Electrolytic reductions. Phenyl-2-nitropropenes From pseudonitrosites. Phenyl-2-propanone (P-2-P) from phenylacetic acid; from phenyl-2-nitropropenes; from monochloroacetone; from phenyl-1,2-propanediol. (Friedel-Crafts Reaction); ketones from phenols. The preparation of amphetamines (Leuckart-Wallach Reaction); (Ritter Reaction); (Willgerodt Reaction); (Hofmann Reaction). Amphetamines From phenyl-2-bromopropane. Preparation of cathinone. The preparation of substituted benzaldehydes; (Duff Reaction); (Elbs Persulfate Reaction); Phenols From Benzaldehydes; (Dakin Reaction). Benzaldehydes from Propenylbenzenes. Ally and propenylbenzenes from natural sources. Propenylbenzenes From phenyl-1-propanols. Phenylpropenes by thermal dehydration. Propenylbenzenes from benzenes; (Quelet Reaction). Preparation of phenyl-1-propanols using the Grignard Reagent; by the reduction of propiophenone. Preparation of cinnamic acids. Cinnamic acids from coumarins. Naturally occurring coumarins. The Crossed Aldol Condensation. The Haloform Reaction. Hydrocinnamic acid from propiophenone. Preparation of nitroethane. Preparation of 4-bromoamphetamine and 4-chloroamphetamine. Preparation of neurotransmitters & neurotoxins and much more…

80 references from scientific and medical journals.

Indexed for fast identification of chemicals, reactions and products.

AMAZON DESCRIPTION

Amphetamine Syntheses Overview & Reference Guide for Professionals (Paperback)
by Otto Snow

Product Details
Paperback: 257 pages
Publisher: Thoth Press (June 2, 1998)
Language: English
ISBN-10: 0966312805
ISBN-13: 978-0966312805

Editorial Reviews Review
Snow’s new book Amphetamine Syntheses is an excellent volley filled with facts, testimony, history and of course lots of chemistry. I found the book quite readable, easy to understand, and noteworthy so far as presenting the overlooked position of the independent neuroscientist and his world. I suspect you will see this book being used by a lot of lawyers, forensic chemists, social scientists and drug philosophers looking for some truth, facts, sanity and common-sense – all collected in one spot. — Psychedelics ReImagined, Thomas Lyttle; Autonomedia 1998

Product Description
the most comprehensive reference guide on the syntheses of amphetamines, phenyethylamines, ephedrine, cathinone, their immediate precursors and precursors. This includes the syntheses of mescaline and all popular psychedelic amphetamines including MDMA, MDEA, 2CB, TMA, DOB, DOM etc. Hundreds of reactions are described including a review of the Controlled Substance Analogue Act. Many of the reactions include: Reductions of phenyl-2-propanone using aluminum amalgam, aluminum turnings or aluminum foil. The preparation of aluminum amalgam, mercury bichloride. Electrolytic reductions. Phenyl-2-nitropropenes From pseudonitrosites. Phenyl-2-propanone (P-2-P) from phenylacetic acid; from phenyl-2-nitropropenes; from monochloroacetone; from phenyl-1,2-propanediol. (Friedel-Crafts Reaction); ketones from phenols. The preparation of amphetamines (Leuckart-Wallach Reaction); (Ritter Reaction); (Willgerodt Reaction); (Hofmann Reaction). Amphetamines From phenyl-2-bromopropane. Preparation of cathinone. The preparation of substituted benzaldehydes; (Duff Reaction); (Elbs Persulfate Reaction); Phenols From Benzaldehydes; (Dakin Reaction). Benzaldehydes from Propenylbenzenes. Ally and propenylbenzenes from natural sources. Propenylbenzenes From phenyl-1-propanols. Phenylpropenes by thermal dehydration. Propenylbenzenes from benzenes; (Quelet Reaction). Preparation of phenyl-1-propanols using the Grignard Reagent; by the reduction of propiophenone. Preparation of cinnamic acids. Cinnamic acids from coumarins. Naturally occurring coumarins. The Crossed Aldol Condensation. The Haloform Reaction. Hydrocinnamic acid from propiophenone. Preparation of nitroethane. Preparation of 4-bromoamphetamine and 4-chloroamphetamine. Preparation of neurotransmitters & neurotoxins and much more… 380 references from scientific and medical journals. Indexed for fast identification of chemicals, reactions and products.

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• Amphetamine Syntheses Overview Reference Guide for Professionals (Revised Industrial Edition)

THC & Tropacocaine
by: Otto Snow

THC & Tropacocaine
By Otto Snow

Product Description:

THC is a new miracle medication, used to treat sleep disorders allergies, inflammatory diseases, auto immune disorders, migraines, addictions, post traumatic stress disorder, anorexia, etc.

Syntheses of THC and chemical analogs are described. Human testing are also included. The extraction of THC (eg. 40%, 70% and 92% THC Hash Oil) from cannabis is detailed. Isomerisation: a quick route from cannabidiol.

The discovery of its endogenous ligand, anandamide (a fatty acid amide) has revolutionized the investigation of this new neurotransmitter system. Anandamides have been used in the treatment of insomnia, allergies and post traumatic stress disorder yet remain undeveloped. Anandamides will replaced THC and marijuana because of ease of synthesis; preparation from commonly available grocery store oils (eg. olive oil). Multiple reactions are explained.

Tropacocaine was discovered as a trace alkaloid in Coca leaves from Java. It is longer acting and less toxic than cocaine.

Tropacocaine is prepared from atropine obtained from nightshade plants. The synthesis of tropacocaine from Datura (eg. nightshade) is described and referenced. Reactions have been translated into English. Millions of Americans are addicted to cocaine and crack, yet tropacocaine has never been studied to assess its value as a replacement medication. 400 refs. Color cover. Laminated.

AMAZON INFO

THC & Tropacocaine (Paperback)
by Otto Snow(Author)

Product Details
Paperback: 182 pages
Publisher: THOTH (August 31, 2004)
Language: English
ISBN-10: 0966312856
ISBN-13: 978-0966312850

Editorial Reviews
Product Description
THC is a new miracle medication, used to treat sleep disorders allergies, inflammatory diseases, auto immune disorders, migraines, addictions, post traumatic stress disorder, anorexia, etc.
Syntheses of THC and chemical analogs are described. Human testing are also included. The extraction of THC (eg. 40%, 70% and 92% THC Hash Oil) from cannabis is detailed. Isomerisation: a quick route from cannabidiol.

The discovery of its endogenous ligand, anandamide (a fatty acid amide) has revolutionized the investigation of this new neurotransmitter system. Anandamides have been used in the treatment of insomnia, allergies and post traumatic stress disorder yet remain undeveloped. Anandamides will replaced THC and marijuana because of ease of synthesis; preparation from commonly available grocery store oils (eg. olive oil). Multiple reactions are explained.

Tropacocaine was discovered as a trace alkaloid in Coca leaves from Java. It is longer acting and less toxic than cocaine.

Tropacocaine is prepared from atropine obtained from nightshade plants. The synthesis of tropacocaine from Datura (eg. nightshade) is described and referenced. Reactions have been translated into English. Millions of Americans are addicted to cocaine and crack, yet tropacocaine has never been studied to assess its value as a replacement medication. 400 refs. Color cover. Laminated.

From the Publisher
Book Includes:

Medical Cannabis: CANNABIS. U.S. (Br.) CANNABIS Cannab; THC; Synhexyl Stereochemical Requirements for Cannabimimetic Activity Cannabinoid Receptors CB2 Agonist Treament of Autoimmunine Disorders CB-2 Receptor Agonist Compounds Inhibition of Cell Proliforation; Cannabinoids in the Treatment of Glaucoma Anandamide Amidase Inhibitors as Analgesic Agents CB1 Agonists for Use in Brain Trauma Erratic Gastrointestial Absorbtion of delta-9-Tetrahydrocannabinol Treating Mental Diseases, Inflammation and Pain with Anandamides

Extraction of Delta-9-Tetrahydrocannabinol from Cannabis Extraction of Cannabis Buds (41% THC Oil) Extraction of Cannabis Buds 2 (40% THC Oil) (92% THC Oil) Preparing Delta-9-Tetrahydrocannabinol Reprocessing of the Residue Left After Fractional Distillation of Cannabis Extracts (82% THC Yellow Oil); THC Syntheses Water Soluble Derivatives of Cannabinoids Synthesis of Compound (4) Ketones from Nitriles THC in the Treatment of Glaucoma in Patients who can not take Beta-blockers Compositions useful as a cannabinoid receptor probe Production of 6,12-Dihydro-6-hydroxy-cannabidiol Production of trans-delta-9-Tetrahydrocannabinol Production of 6,12-Dihydro-6-hydroxy-cannabidiol Production of trans-delta-9-Detrahydrocannabinol Preparation of cis-p-Menth-2-ene-1,8,-diol Novel Tetrahydrocannabinol Type Compounds Preparation of (-)-6a,10a-trans-6a,7,8,10a-Tetrahydrodibenzo[b,d]-pyrans Preparation of Optically Active trans-Hexahydrodibenzopyranones 1-Hydroxy-3-(1,1-dimethylheptyl)-6,6-dimethyl-6,6aR,7,8,10,10aR-hexahydro-9-H-dibenzo[b,d]pyran-9-one Producing 6a,10a-trans-6a,7,8,10a-Tetrahydrodibenzo (b,d)-pyrans 3-(1,2-Dimethylheptyl)-6a,7,10,10a-tetra-hydro-1-hydroxy-6,6,9-trimethyl-6H-dibenzo [b,d]pyran

5-Alkylresorcinols: Preparation of l-Hydroxy-2,6-dimethoxy-4-(tertiaryalkyl)benzene 1-Hydroxy-2,6-dimethoxy-4-(1,1-dimethylheptyl)benzene Divarin Dimethyl Ether from 3,4,5-Trimethoxy-propiophenone Reduction of Ketones to Resorcinols Synthesis of 5-Alkylresorcinols; Synthesis of 5-Ethylresorcinol Preparation of Hexylresorcinol by Electrolytic Reduction of Hexanoylresorcinol Synthesis of 5-Methylresorcinol (Orcinol) 5-Alkylresorcinol from Demethylation of 1-(Alkyl)-3,5-Dimethoxybenzene Demethylation Using Pyridine 5-(1,1-dimethylheptyl)resorcinol Demethylation Using 48% Hydrobromic Acid 5-(1,1-Dimethylheptyl)resorcinol ; Preparation of 5-Alkoxyresorcinols Preparation of Phloroglucinol and its Mono-ethers Preparation of Compounds with Marijuana Activity Formation of Tetrahydrocannabinols by Isomerization of Cannabidiol A. By p-toluenesulfonic acid; B. By sulfuric acid; C. By pyridine hydrochloride; D. By phosphoric acid; E. Sulfamic acid; zinc chloride

Converting cis-Hexahydrodibenzo[b,d]pyran-9-ones to trans-Hexahydrodibenzo[b,d]-pyran-9-ones dl-trans-1-Hydroxy-3-(1,1-dimethyl-heptyl) -6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H- dibenzo[b,d]pyran-9-one dl-trans-1-Hydroxy-3-n-pentyl-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one dl-trans-1-Hydroxy-3-(1,1-dimethyl-heptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one Stereoselective Preparation of Hexahydrodibenzopyranones and intermediates (-)-trans-1-Hydroxy-3-(1,1-dimethyl-heptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one; Acetylation of THC

Delta 1-THC-7-oic acid Analgesic and Anti-inflammatory Agents Platelet Activating Factor Antagonist Non-psychoactive Derivatives of 鈭?-THC-7-oic Acid which have Analgesic and Anti-inflammatory Properties Synthesis of (3R,4R)-鈭?-THC-DMH-7-oic Acid Acetate

Andanamides: Fatty Acid Amides; Preparation of Arachidonyl Ethanolamide Compounds Isolated from the Brain and Synthesized Synthetic Compounds Prepared and Tested Anandamide Amidase Inhibitors as Analgesic Agents Treating Anxiety and Mood Disorders with Oleamide

Fatty Acid Amides Preparation from Common Household Oils Preparation of Oleamide The Reactions Used N-Substituted Amides of Natural Fatty Acids Preparation of N-Methyl Linseed Oil Fatty Acid Amide Preparation of N-Cyclohexyl Linseed Oil Fatty Acid Amide Preparation of Lauric Diethanolamide from Lauroyl Chloride Preparation of Cocoa Fatty Acid Amide Using the Aminolysis Method

Industrial Manufacture of Fatty Acid Ethanolamides reparation of Oleic Acid Monoethanolamide Purification of Fatty Acid Amides Using Urea Preparation of Olive Oil and Coconut Oil Ethanolamides Preparation of Fatty Acids; Isolation of Linoleic Acid Isolation of Oleic Acid from Olive Oil; Production of Monoalkyolamines

TROPACOCAINE

Coca, The Source of Cocaine; COCAINA. U.S., Br.; COCAINE HYDROCHLORIDUM. U.S., Br. Atropine and the Tropeines Cocaine and the Local Anesthetic; Tropacocaine Benzoyl Ester of Ecgonine Using Benzoic Anhydride Tropacocaine from Pseudo-tropine & Benzoic Anhydride Pseudotropine by Electrolytic Reduction of Tropine Tropineone by Oxidation of Tropine; Extraction of Pseudotropine Pseudotropine by the Electrolytic Reduction of Tropinone Tropinone by the Oxydation of Tropine; Tropinone by the Oxydation of Pseudotropine Tropinone by the Electrolytic Reduction of Tropine or Pseudotropine Benzoic Anhydride

Narcotic Daturas Origin of the Name Jimson, or Jamestown Weed; The Huaca-Cachu of Peru Datura Alkaloids ; Hyoscyamine and Atropine; Atropine Sulphate Hyoscine or Scopolamine ; Extraction of Atropine Growing Datura and Related Species BELLADONNA Atropa belladonna; Atropa belladonna (Belladonna) Cultivation Datura stramonium L. (Jimson Weed) ; Datura stramonium (Jimson weed) Cultivation Hyoscyamus niger (Henbane) Cultivation ; Solanum nigram L. (Black Nightshade)

Anyone interested in the construction and future of CB-1 agonists (eg. THC, Oleamide) or cocaine agonists (eg. tropacocaine) will find this book cutting edge.

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Handbook of Pharmaceutical Excipients, 6th Edition (Rowe, Handbook of Pharmaceutical Excipients)
by: Raymond C. Rowe, Paul J. Sheskey, Marian E. Quinn

Handbook of Pharmaceutical Excipients (Rowe, Handbook of Pharmaceutical Excipients)
By Raymond C. Rowe, Paul J. Sheskey, Marian E. Quinn

Publisher: Pharmaceutical Press
Number Of Pages: 917
Publication Date: 2009-07-31
ISBN-10 / ASIN: 0853697922
ISBN-13 / EAN: 9780853697923

Product Description:

"The Handbook of Pharmaceutical Excipients" is internationally recognised as the authoritative source of information on pharmaceutical excipients. "The Handbook of Pharmaceutical Excipients" is a comprehensive guide to the uses, properties and safety of pharmaceutical excipients and is an essential reference for those involved in the development, production, control or regulation of pharmaceutical preparations. The handbook collects together essential data on the physical properties of excipients as well as providing information on their safe use and potential toxicity. All monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names.

Summary: It’ all right !
Rating: 5

It is a very usefull book for pharmaceutical specialists. It is a good which
help us very much.

Summary: Handbook of Pharmaceutical Excipients
Rating: 5

This is an excellent book that contains every phamaceutical excipient that I have ever had the need to know about. I work for a dietary supplement manufacturer and we quite often get calls from customers that want to know all about all those "other ingredients" that are listed on product cartons. The book has a section for each excipient and each excipient has the following sections: Nonproprietary Names, Synonyms, Chemical Name and CAS Registry Number, Empirical Formula and Molecular Weight, Structural Formula, Functional Category, Applications in Pharmaceutical Formulation or Technology, Description, Pharmacopeial Specifications, Typical Properties, stability and Storage Conditions, Incompatibilities, Method of Manufacture, Safety, Handling Precautions, Regulatory Status, Pharmacopeias, Related Substances, Comments, Specific References, General References, and Authors. While I have a background in Biology, I found several of the sections to be easy to understand by several of our employees that do not have a science background. While, still, there was highly technical/scientific information as well. Each excipient’s information is contained in 2-4 pages. The book is arranged alphabetically which makes finding information easy. In addition, it contains an index that is very well constructed. For example: If you are looking for an Emulsifying Agent, the index lists all the excipients that can be used for that purpose. I can’t say enough how easy this book is to use. Its information is pared down to the essential text, and is chocked full of graphs, charts and microscopic photos of the excipients.

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by: Sean C. Sweetman

Martindale: The Complete Drug Reference, 36th Edition
By Sean C. Sweetman

Publisher: Pharmaceutical Press
Number Of Pages: 3694
Publication Date: 2009-03-16
ISBN-10 / ASIN: 0853698406
ISBN-13 / EAN: 9780853698401

Product Description:

This book provides reliable, unbiased and evaluated information on drugs and medicines used throughout the world. Each new drug licensed for use has its own potential benefits and adverse effects, and its own profile for dosage, administration and indications. Furthermore, manufacturers make regular changes to existing drug names and formulations, which can affect their interactions and safe usage. Health professionals require the correct answers and need to have confidence in the drugs information they use – but with medicines evolving at this rate, how can they be sure their knowledge is up to date? "Martindale" contains up to date information about more than 5,800 substances. Each and every entry is reviewed by our pharmaceutical editors to ensure health professionals have the most current data. Formulations change. Definitions change. Names change. But you can always trust "Martindale".

Summary: Good reference to have
Rating: 4

This is a good reference to have on your bookcase if you are a pharmacist or doctor. Theres lots of information that is hard to find in other references.

Summary: A good place to find descriptions of genuinely obscure drugs
Rating: 5

This book contains references to some drugs that I couldn’t find anywhere else. Drugs that are no longer in common use, that are used exclusively outside the US, or that have toxicity levels that are normally unacceptable may still find a listing in Martindale. The index is very thorough. I had only two complaints: 1) I don’t understand why some drugs information is dropped when new editions come out — I would rather see the book simply grow, rather than sometimes requiring access to older editions, and 2) it doesn’t present molecular structures (sigh). Still, the opportunity to find information that is otherwise simply unavailable (try to find dosing schedules for potassium bromide elsewhere, to pick an example) outweighs any complaints.

Summary: A must have for anyone in the nedical community.
Rating: 5

Great reference for any pharmaceutical drug. Complete and accurate information that can help in a variety of problems.

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by: Elizabeth Williamson, Samuel Driver, Karen Baxter

Stockley’s Herbal Medicines Interactions
By Elizabeth Williamson, Samuel Driver, Karen Baxter

Publisher: Pharmaceutical Press
Number Of Pages: 400
Publication Date: 2009-07-24
ISBN-10 / ASIN: 0853697604
ISBN-13 / EAN: 9780853697602

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This is a professional level major reference work containing information, in A-Z format, on herb-drug, herb-supplement, herb -food and herb-laboratory test interactions; all of which is data referenced. Commercial herbal medicinal products are increasingly consumed on a regular basis by people in the developed world. Often such products are taken concurrently with conventional medicines, frequently without the knowledge of health care professionals. As more evidence has become available, there has been an increasing awareness of the potential and actual problems of interactions, often dangerous, between conventional medicines and herbal medicines. This proposed new major reference brings together available data on approximately 200 of the most commonly used herbal medicines in highly structured, rigorously scientific monographs. Although our texts on herbal medicines and drug interactions include the major well-known interactions, this text is able to treat the subject in considerably more detail.

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ISBN-13 / EAN: 9780853697855

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This is a practical guide for students; an insight into their hospital preregistration training. It is one of the RPS "Tomorrow’s Pharmacist" series. The proposed text aims to provide a practical explanation for undergraduates and preregistration trainees on what to expect from a hospital preregistration training programme. The text uses an informal writing style and is based on tips, hints, past experiences and anecdotes from the authors in their roles as preregistration tutors. The experiences are from a district general hospital and a large teaching hospital perspective.

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ISBN-13 / EAN: 9783211782064

Product Description:

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

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Dale and Appelbe’s Pharmacy Law and Ethics, 9th Edition
by: Gordon E. Appelbe, Joy Wingfield

Dale and Appelbe’s Pharmacy Law and Ethics, 9th Edition
By Gordon E. Appelbe, Joy Wingfield

Publisher: Pharmaceutical Press
Number Of Pages: 553
Publication Date: 2009-08-17
ISBN-10 / ASIN: 0853698279
ISBN-13 / EAN: 9780853698272

Product Description:

This is a comprehensive guide to law and ethics for pharmacy practice in the UK. "Dale and Appelbe’s Pharmacy Law and Ethics" has become established as the standard student textbook and reference work on this subject in the UK. A knowledge of pharmacy law is a substantial and compulsory component of the undergraduate and pre-registration pharmacy syllabus in the UK and changes to the syllabus and practice require the text to be updated regularly. This revised edition provides a comprehensive guide to the law that affects the practice of pharmacy and the use of medicines in Great Britain, and complete coverage of the pharmacy undergraduate and pre-registration syllabus and British law relating to medicines and poisons.

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LSD
by: Otto Snow

LSD
By Otto Snow

Paperback: 246 pages
Publisher: Thoth Press (November 2003)
Language: English
ISBN-10: 0966312848
ISBN-13: 978-0966312843

Product Description:

At age 15, Otto developed hemi-paraesthesic migraine headaches. These cluster migraines resemble a stroke. He was given narcotics, barbiturates and ergot alkaloids. The drugs were making him ill. He learned of a new medication that might help. The drug was LSD-25 and it worked.

His physicians would not prescribe LSD so Otto entered the world of LSD. Several laboratories provided him and other patients with the medication. Included are comments and research from the greatest scientists of the twentieth century. Personal satori experiences. At nineteen, Otto discontinued his exploration of LSD.

LSD is the most comprehensive book ever written on the synthesis of LSD. Otto includes the reactions and the chemistry behind the reactions. Many simplified reactions (e.g. diethylamine from vodka, lysergic acid directly from Claviceps sugar culture, coupling agents from scratch). Extractions translated to English.

LSD is written by someone who has been there and knows the subject/chemistry first hand. LSD is as popular today as it was in the 1970s and 1960s. For many it is a party drug, for others it is a medication. The Decade of the Brain heralded in a new interest in psychedelics and their medical application.

The book is illustrated by Tulasne, Chase, Gill and others. LSD is packed with chemistry for future generations of neurochemists and explorers. 275 references. UV laminated.

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xPharm® – The Comprehensive Pharmacology Reference (January 2008)
by: Editors-in-Chief: S.J. Enna and David B. Bylund
en | Elsevier Science

PDF 16672 pages
Data Date -> Available online 8 January 2008

xPharm, a state of the art, online, comprehensive pharmacology reference work.
xPharm is comprised of four searchable and highly interlinked databases covering molecular
Targets, including receptors, enzymes, transporters and ion channels, chemical
Agents, including both drugs and endogenous compounds, clinical Disorders, and basic
pharmacological Principles.

xPharm is designed to exploit the advantages provided by online publishing in allowing
a user to customize information retrieval by quickly identifying and linking data from
a large reference work. In addition, electronic publishing permits timely updates, which
are not possible with printed material. xPharm is unique in that it was constructed from
the beginning as an online reference work, rather than trying to adapt a print product to
an online venue.

The idea for four databases was driven by the fact that Agents, including drugs, which
are the core of pharmacology, act at molecular Targets to treat Disorders. The Principles
database is included as a repository of information fundamental to the discipline but
generally independent of the chemical entity, site of action, or clinical use. Each xPharm
record is composed and reviewed by experts and the information placed within a highly
structured format consistent within each database. xPharm is rich in the numerical data
used to define pharmacological relationships, with each fact referenced so that more
detailed information can be obtained if necessary. All narratives are hyperlinked to related
records across databases to facilitate navigation within a subject area. The records are
organized in a hierarchical manner to facilitate browsing at increasing levels of specialization
depending upon the needs and the background of the user. For example, one could
begin with 7 Transmembrane Receptors, then advance to Adrenoceptors, and on to Beta
Adrenoceptors and finally to Beta-2 Adrenoceptors. Alternatively, the user can easily
navigate from record to record with a click of the mouse. Starting in the Principles record,
Intrinsic Regulation of the Vasculature, one might go to the Essential Hypertension
record, then to Altenolol and finally to the Beta-1 Adrenoceptor record. xPharm also
contains external links to related databases providing a seamless network of pharmacological
information including access to full text articles, protein and gene sequences,
suppliers, and other related web sites, including those of funding agencies.
xPharm is designed for the bench scientist working in academic, industrial or government
laboratories, although students also find it very useful.While clinical information is
provided in some records, the work is not intended as a primary source for clinicians and
should not be used in this way. Rather, clinical data, such as doses, dosage forms, side
effects, and potential drug interactions, are included as background information for those
attempting to design or develop new medications, or who are conducting research aimed
at defining the molecular mechanisms responsible for certain clinical responses. With
regard to targets, emphasis is placed on those proteins known to have pharmacological
relevance. Likewise, although information on drug toxicities is included, xPharm is not
intended to be a comprehensive toxicology reference.

Currently, xPharm consists of approximately 4000 individual records prepared by
nearly 600 authors. If printed it would total over 20,000 pages, making it the world’s
largest medical reference work. Additional records are added, and records revised, biannually.
Each new record is reviewed by authorities on the topic before it is published,
and is revised and updated as necessary. Those interested in authoring or revising records
should contact xpharm-mail@elsevier.com.
We extend our sincere thanks to the hundreds of authors, the members of the Editorial
Board, and to the staff and management at Elsevier, in particular Tim Stevenson and Zoe
Kruze, for their dedication and commitment. Thanks to their efforts, xPharm has developed
into the equivalent of an expert pharmacologist, on-call 24 hours a day, capable of
answering your questions, and providing new insights, in this dynamic and important field.

S. J. Enna
David B. Bylund
Executive Editor
October, 2008

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Guidance for the Implementation of a Quality Management System in Drug Testing Laboratories: A Commitment to Quality and Continuous Improvement (United Nations Office at Vienna)
by: United Nations

Guidance for the Implementation of a Quality Management System in Drug Testing Laboratories: A Commitment to Quality and Continuous Improvement (United Nations Office at Vienna)
By United Nations

Publisher: United Nations
Number Of Pages: 48
Publication Date: 2009-04-30
ISBN-10 / ASIN: 9211482399
ISBN-13 / EAN: 9789211482393

Product Description:

Offers guidance for the implementation of a quality management system in drug testing laboratories: a commitment to quality and continuous improvement.

The quality of analyses and results of drug analysis laboratories have significant implications for the justice system, law enforcement, crime prevention and health policy, as well as for the international harmonization and worldwide exchange and coordination of drug information and data. The document aims to provide guidance to deliver high quality in a forensic laboratory, use the appropriate techniques to find the "answers" and to improve it constantly. It is a "how to do document" and includes some areas that are not explicitly covered in depth by ISO 17025.

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Advances in Bioactivation Research (Biotechnology: Pharmaceutical Aspects)
by: Adnan Elfarra

Advances in Bioactivation Research (Biotechnology: Pharmaceutical Aspects)
By Adnan Elfarra

Publisher: Springer
Number Of Pages: 504
Publication Date: 2008-09-19
ISBN-10 / ASIN: 0387772995
ISBN-13 / EAN: 9780387772998

Product Description:

This volume will provide researchers with recent information on bioactivation reactions of drugs and toxicants and will provide examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections of this volume, focus will be on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences. In these sections, the contributors will demonstrate the integration of bioactivation research in several research areas, including new drug design, drug development, mechanisms of cell death, toxicity and carcinogenicity, metabolite-specific biomarkers of exposure and effect, and extrapolations of results from animal models to humans.

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