Posted: November 20th, 2008, 1:43pm CET by addebook
Medicinal Protein Engineering
Medicinal Protein Engineering
By Yury E. Khudyakov
Publisher: CRC
Number Of Pages: 592
Publication Date: 2008-11-14
ISBN-10 / ASIN: 0849373689
ISBN-13 / EAN: 9780849373688
Binding: Hardcover
AnAll-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field
From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.
Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.
Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases
Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.
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Posted: November 20th, 2008, 1:42pm CET by addebook
Drug Truths: Dispelling the Myths About Pharma R & D
by John L. LaMattina
Drug Truths: Dispelling the Myths About Pharma R & D
By John L. LaMattina
Publisher: Wiley
Number Of Pages: 136
Publication Date: 2008-11-10
ISBN-10 / ASIN: 0470393181
ISBN-13 / EAN: 9780470393185
Binding: Paperback
This book answers the questions about the process and costs of pharmaceutical R & D in a compelling narrative focused on the discovery and development of important new medicines. It gives an insider’s account of the pharmaceutical industry drug discovery process, the very real costs of misperceptions about the industry, the high stakes–both economic and scientific–of developing drugs, the triumphs that come when new compounds reach the market and save lives, and the despair that follows when new compounds fail. In the book, John LaMattina, former president of Pfizer Global Research and Development, weaves themes critical to a vital drug discovery environment in the context. This is a story that Dr. LaMattina is uniquely qualified to tell.
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Posted: November 20th, 2008, 1:41pm CET by addebook
Pharmacology, Doping and Sports: A Complete Scientific Guide for Athletes, Coaches, Physicians, Scientists and Administrators
by Jean L. Fourcr
Pharmacology, Doping and Sports: A Complete Scientific Guide for Athletes, Coaches, Physicians, Scientists and Administrators
By Jean L. Fourcr
Publisher: Routledge
Number Of Pages: 240
Publication Date: 2008-10-14
ISBN-10 / ASIN: 0415428459
ISBN-13 / EAN: 9780415428453
Binding: Hardcover
The work of dope testers is constantly being obstructed by the development of ever harder to trace new forms of banned substances. Organisations such as the World Anti-Doping Association and the United States Anti-Doping Agency are pioneering cutting-edge techniques designed to keep competition at the highest level fair and safe, and must ensure that their drug testing laboratories adhere to the highest scientific standards. In “Pharmacology, Doping and Sports” these techniques and procedures are explained by the anti-doping experts who practice them.Broad-ranging in scope, this book examines the effects of performance-enhancing substances on the athlete’s health; the role of anti-doping procedures as an ethical question, and explains the background to, and the emergence of, the anti-doping movement. The book also offers in-depth analysis of key scientific matters, such as: standard analytical and diagnostic tests for sports doping; regulatory standards for laboratory proficiency; common performance-enhancing techniques such as anabolic and designer steroids, blood doping, growth hormones, and gene doping; and, carbon-isotope ratio testing. Written by some of the world’s leading authorities on the science of sports doping, “Pharmacology, Doping and Sports” provides an invaluable study of up-to-the-minute anti-doping techniques. This book is essential reading for all sports scientists, coaches, policy-makers, students and athletes interested in the science or ethics of doping in sport.
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Posted: November 20th, 2008, 1:40pm CET by addebook
Concepts In Clinical Pharmacokinetics
Concepts In Clinical Pharmacokinetics
By Joseph T. Dipiro, William J. Spruill, William E. Wade, Robert A. Blouin, Jane M. Pruemer
Publisher: American Society of Health-System Pharmacists
Number Of Pages: 230
Publication Date: 2005-10-30
ISBN-10 / ASIN: 1585281247
ISBN-13 / EAN: 9781585281244
Binding: Paperback
Programmed manual presents basic pharmacokinetic concepts and procedures. Material relates to individualization of drug dose regimens. Topics include pharmacokinetics, half-life, elimination rate, AUC, two-compartment models, drug elimination process, vancomycin, and more. For pharmacists and practitioners. Softcover. DNLM: Pharmacokinetics-Programmed Instruction.
Summary: A Nice Introductory Book
Rating: 4
Let’s me first say, my background is physical chemistry and analytical chemistry, so I have a limited knowledge on pharmacokinetics. I purchased this textbook because I have the options to take an online 15 weeks class along this book with University of Georgia and to take an online test from ASHP after completion of this book. I did the latter. The book is actually short. Although the book is designed to be a textbook for a 15-weeks online course, I was able to read through it within 3 weeks, passed the ASHP test while holding a full time job. I admit that I often spent 2 hour a day reading the book and many people may not able to afford. That being said, I am certain that most people can finish this book within 15 weeks at a very relax pace. I find the book very easy to understand and enjoyable to read. The math requirement for this book is on the algebra level, although a basic calculus level is needed to fully appreciate the theories and the math. The book has some typos, especially during the “Exercises and Problems” sections. In addition, it is more expensive than other pharmacokinetics books on the market.
I highly recommend this book for anyone who is new to pharmacokinetics and want a short, enjoyable introductory book.
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Posted: November 20th, 2008, 1:39pm CET by addebook
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
by B.E. Maryanoff, A.B. Reitz
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
By B.E. Maryanoff, A.B. Reitz
Publisher: Elsevier Science
Number Of Pages: 336
Publication Date: 1999-04-01
ISBN-10 / ASIN: 0762300647
ISBN-13 / EAN: 9780762300648
Binding: Hardcover
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
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Posted: November 20th, 2008, 6:59am CET by addebook
Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices
by Kim Huynh-Ba
Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices
By Kim Huynh-Ba
Publisher: Springer
Number Of Pages: 328
Publication Date: 2008-11-25
ISBN-10 / ASIN: 0387856269
ISBN-13 / EAN: 9780387856261
Binding: Hardcover
A COMPREHENSIVE AND PRACTICAL GUIDE TO STABILITY TESTING IN PHARMACEUTICAL DEVELOPMENT
Stability testing is required to demonstrate that a pharmaceutical product meets its acceptance criteria throughout its shelf life and to gain regulatory approval for commercialization. Assessing drug product stability and safety can be quite complicated, and stability profile can impact many functional areas, including analytical testing, formulation development, toxicology, quality, and regulatory affairs.
Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices is the first volume to cover all aspects of stability testing in pharmaceutical development. It presents a scientific understanding of regulations and balances methodologies and best practices. Comprising 17 chapters, it provides a wealth of resources for pharmaceutical companies, educational institutions, and manufacturing laboratories to use as either a supplementary text for stability training courses or as a reference book for pharmaceutical practitioners.
Topics covered include:
Latest regulations for stability testing, including cGMP requirements, ICH guidelines, and global guidances from WHO, ASEAN, EMRO, and other regions.
Post-approval considerations and regulatory filing strategies to support a global supply chain.
Methodologies, including development of a stability-indicating method, method validation, and transfer. This book also discusses physical stability, non-chromatographic methodologies, and spectroscopic applications.
Setting specifications, monitoring impurities, and establishing shelf-life of pharmaceutical products.
Data management, including stability reports, CMC, and discussion of out-of-specification (OOS) and out-of-trend (OOT).
USP-NF testing in support of stability.
Current industry best practices on stability operation, validation, and calibration of stability chambers including considerations for photo-stability testing.
Discussion of matrixing and bracketing to support reduced stability testing.
Overview of stability programs for biologics and drug-in-devices pharmaceutical products.
This collective work was written by a group of prominent international experts, who have been directly responsible for instituting industry best practices and establishing the current stability guidelines.
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Posted: November 20th, 2008, 6:58am CET by addebook
In Vitro Methods in Pharmaceutical Research
by Jose V. Castell, Maria Jose Gmez-Lechn
In Vitro Methods in Pharmaceutical Research
By Jose V. Castell, Maria Jose Gmez-Lechn
Publisher: Academic Press
Number Of Pages: 467
Publication Date: 1997-01-15
ISBN-10 / ASIN: 012163390X
ISBN-13 / EAN: 9780121633905
Binding: Hardcover
In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies.
Key Features
* Meets the continuing demand for information in this field
* Compares In Vitro techniques with other methods
* Describes cell-culture methods used to investigate toxicity in cells derived from different organs
* Includes contributions by leading experts in the field
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Posted: November 20th, 2008, 6:57am CET by addebook
Cyclic Gmp: Synthesis, Metabolism, and Function (Advances in Pharmacology)
by Ferid Murad, J. Thomas August, M. W. Anders
Cyclic Gmp: Synthesis, Metabolism, and Function (Advances in Pharmacology)
By Ferid Murad, J. Thomas August, M. W. Anders
Publisher: Academic Press
Number Of Pages: 335
Publication Date: 1994-01-15
ISBN-10 / ASIN: 0120329263
ISBN-13 / EAN: 9780120329267
Binding: Hardcover
This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.
Key Features
* Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis
* Cyclic GMP-dependent protein kinase
* Hormones and ligands that regulate GMP formation and/or metabolism
* Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport
* Clinical studies with cyclic GMP and atrial natriuretic peptide
* Important questions and experiments for the future
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Posted: November 20th, 2008, 6:56am CET by addebook
Advances in Clinical Chemistry: v. 7
by H Sobotka
Advances in Clinical Chemistry: v. 7
By H Sobotka
Publisher: Academic Press Inc.,U.S.
Number Of Pages:
Publication Date:
ISBN-10 / ASIN: 0120103079
ISBN-13 / EAN: 9780120103072
Binding: Hardcover
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Posted: November 20th, 2008, 6:55am CET by addebook
Advances in Clinical Chemistry: v. 13
by
Advances in Clinical Chemistry: v. 13
Publisher: Academic Press Inc.,U.S.
Number Of Pages: 533
Publication Date: 1971-01
ISBN-10 / ASIN: 0120103133
ISBN-13 / EAN: 9780120103133
Binding: Hardcover
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Posted: November 20th, 2008, 6:54am CET by addebook
Advances in Clinical Chemistry: v. 8
by H Sobotka
Advances in Clinical Chemistry: v. 8
By H Sobotka
Publisher: Academic Press Inc.,U.S.
Number Of Pages:
Publication Date:
ISBN-10 / ASIN: 0120103087
ISBN-13 / EAN: 9780120103089
Binding: Hardcover
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Posted: November 20th, 2008, 6:53am CET by addebook
Advances in Clinical Chemistry: v. 6
by H Sobotka
Advances in Clinical Chemistry: v. 6
By H Sobotka
Publisher: Academic Press Inc.,U.S.
Number Of Pages:
Publication Date:
ISBN-10 / ASIN: 0120103060
ISBN-13 / EAN: 9780120103065
Binding: Hardcover
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Posted: November 20th, 2008, 6:52am CET by addebook
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
by B.E. Maryanoff, A.B. Reitz
Advances in Medicinal Chemistry, Volume 4 (Advances in Medicinal Chemistry)
By B.E. Maryanoff, A.B. Reitz
Publisher: Elsevier Science
Number Of Pages: 336
Publication Date: 1999-04-01
ISBN-10 / ASIN: 0762300647
ISBN-13 / EAN: 9780762300648
Binding: Hardcover
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
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Posted: November 15th, 2008, 12:19pm CET by addebook
The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders
by Divya Vohora
The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders
By Divya Vohora
Publisher: CRC
Number Of Pages: 400
Publication Date: 2008-11-13
ISBN-10 / ASIN: 1420053922
ISBN-13 / EAN: 9781420053920
Binding: Hardcover
Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resourcepresents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studies indicating earliest possible stages of development.The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, selective ligands, and therapeutic potential. Several chapters address disorders involving H3, including Alzheimer’s, ADHD, sleep disorders, epilepsy, obesity, and psychiatric and neurodegenerative disorders.
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Posted: November 13th, 2008, 3:23am CET by addebook
Bioinformatics in Cancer and Cancer Therapy (Cancer Drug Discovery and Development)
by Gavin J. Gordon
Bioinformatics in Cancer and Cancer Therapy (Cancer Drug Discovery and Development)
By Gavin J. Gordon
Publisher: Humana Press
Number Of Pages: 202
Publication Date: 2008-11-21
ISBN-10 / ASIN: 1588297535
ISBN-13 / EAN: 9781588297532
Binding: Hardcover
Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Although no single person or group started the field wholly on their own, Temple Smith, Ph.D., a professor at Boston University, is generally credited with coining the term. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics, fields of study that have historically existed as mutually exclusive disciplines.
Concurrently, bioinformatics has vaulted into the public’s eye in lay newspapers and magazines, most notably in the area of (personalized) DNA sequencing. The combined result is that bioinformatics is being heralded as a panacea to the current limitations in the clinical management of cancer. While certainly over optimistic in some regards, this designation is not without promise particularly in the area of cancer diagnosis and prognosis.
The focus of this book is to: i) to provide a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments, ii) to show how a bioinformatics approach has been used to characterize various cancer-related processes, and iii) to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.
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Medical (15 unread)