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Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation (Progress in Inflammation Research)
Posted: May 17th, 2007, 8:55pm CEST by Wael

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Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and