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Posted: November 15th, 2007, 8:57am CET by X
Restriction Endonucleases (Nucleic Acids and Molecular Biology)CRC | ISBN: 084938205X | Edition - 2007-07-23 | PDF | 368 pages | 14.3Mb
The automated identification of biological objects or groups has been a dream among taxonomists and systematists for centuries. However, progress in designing and implementing practical systems for fully automated taxon identification has been frustratingly slow. Regardless, the dream has never died. Recent developments in computer architectures and innovations in software design have placed the tools needed to realize this vision in the hands of the systematics community, not several years hence, but now. And not just for DNA barcodes or other molecular data, but for digital images of organisms, digital sounds, digitized chemical data - essentially any type of digital data. Based on evidence accumulated over the last decade and written by applied researchers, Automated Taxon Identification in Systematics explores contemporary applications of quantitative approaches to the problem of taxon recognition. The book begins by reviewing the current state of systematics and placing automated taxon identification in the context of contemporary trends, needs, and opportunities. The chapters present and evaluate different aspects of current automated system designs. They then provide descriptions of case studies in which different theoretical and practical aspects of the overall group-identification problem are identified, analyzed, and discussed. A recurring theme through the chapters is the relationship between taxonomic identification, automated group identification, and morphometrics. This collection provides a bridge between these communities and between them and the wider world of applied taxonomy. The only book-length treatment that explores automated group identification in systematic context, this text also includes introductions to basic aspects of the fields of contemporary artificial intelligence and mathematical group recognition for the entire biological community.
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Posted: November 15th, 2007, 8:56am CET by X
Immunology for Life ScientistsJohn Wiley & Sons | ISBN: 0470014016 | Edition - April 1, 2005 | PDF | 368 pages | 4.33 MB
This thoroughly revised and updated new edition provides outstanding coverage of the most important aspects of immunology. Assuming no previous knowledge of the subject, the book gives step-by-step detail on topics such as antigens, hypersensitivity, autoimmunity, reproductive immunity and immunodeficiency. There is an accompanying website with supplementary material.
This is the second edition of the popular textbook Immunology for Life Scientists. Thoroughly updated to reflect the changes both within the subject itself as well as in the curriculum, this is the textbook for anyone studying immunology as past of another degree course. No previous instruction in the subject is assumed, rather a broad and basic knowledge is slowly built up and a sound understanding of the fundamentals of the discipline introduced in a step-by-step logical manner. Readers are encouraged to develop their own learning by reading the recommended review articles and attempting the self-assessment available in the book. clearly written chapters covers all key aspects of basic immunology keywords and concepts highlighted and summarised self-assessment multiple choice questions
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Posted: November 15th, 2007, 8:56am CET by X
Introduction to Enzyme and Coenzyme ChemistryBlackwell Publishing Limited | ISBN: 1405114525 | 2 Edition - October 1, 2004 | PDF | 304 pages | 5.83 MB
Enzyme catalysis is a topic of fundamental importance in organic, bio-organic and medicinal chemistry. This new edition of a very popular textbook provides a concise introduction to the underlying principles and mechanisms of enzyme and coenzyme action from a chemical perspective.Whilst retaining the overall structure of the first edition - preliminary chapters describe the basic principles of enzyme structure and catalysis moving through to detailed discussions of the major classes of enzyme processes in the later chapters - the book has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action. A major feature of the second edition is the inclusion of two-colour figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. Problems, with outline answers, at the end of each chapter give the student the chance to the check their understanding of the material.As a concise but comprehensive account, Introduction to Enzyme and Coenzyme Chemistry will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry.
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Posted: November 15th, 2007, 8:55am CET by X
P. Reed Larsen MD, FACP, FRCP (Author), "Williams Textbook of Endocrinology, 10th ed."Publisher: Elsevier Science | English | PDB | 2003 | 2096 pages | 15.5 MB | ISBN: 0721691846 | RS.com
This tenth edition of Williams Textbook of Endocrinology is a milestone in many respects. A tenth edition per se is testimony to the enduring accomplishments of their predecessors, who have consistently created a product that remains the most popular textbook in this field. It is also now a half century since the publication of the first edition of Williams, a landmark suitably celebrated in a foreword by our coauthor and former editor, Dr. Jean Wilson. Two internationally renowned endocrinologists, Drs. Shlomo Melmed and Kenneth Polonsky, have joined Drs. Reed Larsen and Henry Kronenberg to formulate, co-edit, and assemble this volume. They will strive to meet the high standards maintained by Drs. Wilson and Daniel Foster during their editorial leadership.
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Posted: November 15th, 2007, 8:55am CET by X
Frederick L. Greene, David L. Page, Irving D. Fleming (Editors), "AJCC Cancer Staging Handbook 6th Edition"Publisher: Springer | English | PDB | 2002 | 164 pages | 2.69 MB | ISBN: 0387954694 | RS.com
The Sixth Edition of the AJCC Cancer Staging Manual is a compendium of all currently available information on the staging of cancer for most clinically important anatomic sites. It has been developed by the American Joint Committee on Cancer (AJCC) in cooperation with the TNM Committee of the International Union Against Cancer (UICC). The two organizations have worked together at every level to create a staging schema that remains uniform throughout. The current climate that allows for a consistency of staging worldwide has been made possible by the mutual respect and diligence of those working in the staging area for both the AJCC and the UICC.
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Posted: November 15th, 2007, 8:54am CET by X
The Human Heart: A Basic Guide to Heart Disease by Brendan PhibbsLippincott Williams & Wilkins (2007-01-01) | ISBN: 0781767776 | 240 pages | 15 MB | CHM
Book Description:
This basic text on the heart and heart diseases is geared to everyone on the cardiovascular care team, including emergency personnel, interns, residents, nurses, patients, and families. The thoroughly updated Second Edition describes current technologies for noninvasive diagnosis and treatment of coronary and vascular disease. Coverage includes a complete description of echocardiographic stress testing and new information on implanted defibrillators, indications for coronary arteriography, new drugs for heart failure, new cardiac resuscitation procedures, and use of ventricular synchronizing pacemakers. Also included are discussions of recently discovered lethal entities such as Brugada's syndrome, short QT syndrome, and the arrhythmogenic ventricle.
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Posted: November 15th, 2007, 8:54am CET by X
Ramaswamy, Md. Govindan, Matthew A., MD Arquette (Editors) ,"The Washington Manual of Oncology 1st edition"Publisher: Lippincott Williams & Wilkins | English | PDB | June 2002 | 47 pages | 3.16 MB | ISBN: 0786973218 | RS.com
These are exciting times in oncology. The novel imaging techniques, improved supportive care, and the availability of several new agents that have novel mechanisms of action hold considerable promise in improving the outcomes of cancer patients. In this era of information overload, it is critically important to have a practical manual that is helpful to physicians taking care of patients with cancer.
The chapters are arranged in a logical order beginning with evaluation of symptoms and proceeding in an orderly fashion through the work-up, staging, and stage-directed therapy, and finally ending with discussion on epidemiology and current focus of research. The authors have embarked on this first edition of The Washington Manual of Oncology to provide a very practical manual that is helpful to medical residents, fellows in training, nurse practitioners, and other practitioners of clinical oncology. Their plan is to publish this book in a timely fashion every two years to keep the information current and up-to-date.
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Posted: November 15th, 2007, 8:54am CET by X
The Nutritional Biochemistry of Chromium (III) - John VincentElsevier, 2007 | ISBN:0444530711 | English | PDF | 292 pages | 2.2 MB
Chromium nutritional supplements are the second best selling mineral supplements after calcium as chromium is found in pills, sports drinks, chewing gums, smoothies, and numerous other products. Chromium has been promoted to promote weight loss and muscle development and most recently to be available to treat the symptoms of type 2 diabetes and related conditions.
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Posted: November 15th, 2007, 8:53am CET by X
Geoffrey J. Gladstone, Evan H. Black, Shoib Myint, Brian G. Brazzo,
"Oculoplastic Surgery Atlas "Publisher: Springer | Pages: 114 | 2005-03-03 | ISBN: 0387200797 | PDF | 3.01 MB
Written by top oculoplastic surgeons in the field, including Frank A. Nesi, MD, this atlas combines an innovative educational technique: line drawings that correspond to videoclips on DVD. The text's distinguished authors have perfected the most frequently performed oculoplastic surgical techniques. Their atlas series is designed to instruct all ophthalmologists who wish to learn these techniques and thus enhance their income. This volume covers the latest in cosmetic facial surgery techniques including endoscopic foreheadplasty, direct eyebrow lift, rhytidectomy surgery, mid-face lift and facial cosmetic Botox. Mastery of these procedures is made easier by following the step-by-step illustrations that are complemented by videoclips on DVD. The study of the supporting anatomy, followed by clear cut guidelines with heavily illustrated techniques, offers a format which will allow the learner to gain the necessary understanding for achieving a more favorable result.
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Posted: November 15th, 2007, 8:53am CET by X
Nuclear Reprogramming: Methods and ProtocolsHumana Press | ISBN: 1588293793 | 1 Edition - December 5, 2005 | PDF | 348 pages | 3.0 MB
A wide-ranging collection of readily reproducible methods for performing nuclear reprogramming by nuclear transfer in several different species, by fusion through both chemical treatment and electrically shocking cells, and by in vivo treatment of cells with cell extracts. Several methods of monitoring nuclear reprogramming are also presented, including the use of transgenic markers, activation of telomerase as an ES-specific marker, light and electron microscopic observation of structural changes in the nucleus, and verification of surface marker expression and the differentiation potential of stem cells. Biochemical methods are provided for the examination of chromatin protein modifications, nucleosomal footprinting, transcription factor binding, and the study of DNA methylation changes both at the specific locus level and at the level of the whole nucleus.
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Posted: November 15th, 2007, 8:52am CET by X
Hot Topics in Infection and Immunity in Children III (Advances in Experimental Medicine and Biology)Springer | ISBN: 038731783X | 1 Edition - May 24, 2006 | PDF | 276 pages | 3.0 MB
This volume covers topics in infectious diseases in children and is intended for Pediatric Infectious Disease trainees, trainers, and all those who manage children with infections. There is a balance of clinical basic science. In response to numerous requests, additional tropical topics are covered in some depth. As before, the emphasis is on hot topics of clinical relevance delivered by world class speakers.
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Posted: November 15th, 2007, 8:52am CET by X
Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and DiseaseWiley-VCH | ISBN: 3527311416 | Edition March 10, 2006 | PDF | 633 pages | 4.7 MB
This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.
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Posted: November 15th, 2007, 8:51am CET by X
Eugene Braunwald (Author), "A Textbook of Cardiovascular Medicine, 6th ed."Publisher: W. B. Saunders Company | English | 2001 | 191 pages | 7.79 MB | ISBN: 0721685617 | RS.com
Cardiovascular disease is now, more than ever, a global problem with enormous economic consequences. The various forms of heart disease in different economies and cultures are presented in the new opening chapter by Gaziano, and principles of cost-effective practice are described in a new chapter by Hlatky and Mark. Part II, The Examination of the Patient, begins with the clinical examination and moves progressively from simple to more sophisticated noninvasive and invasive techniques. All of these approaches are described in detail with many new illustrations. The new chapter "Relative Merits of Cardiovascular Diagnostic Techniques," by Beller, provides a rational approach to the selection among several methods available to image the heart.
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Posted: November 15th, 2007, 8:51am CET by X
K. Frank, Michael M, Harvey I, John P (Authors), "Samter's Immunologic Diseases 6th edition"Publisher: Lippincott Williams & Wilkins | English | 103 pages | 13.2 MB | ISBN: 0071388365 | RS.com
In this sixth edition the authors continue to emphasize the immune system of humans and the immunologic basis of human disease. The bibliographies are still rather extensive but have the added intent of providing a pathway to "finding the right additional information." Many authors are new and the emphasis in some chapters has changed as might be expected in a fast-moving field such as immunology. Overall, however, this edition is similar to the previous one in content and emphasis. They faced an issue in this edition of how to handle infectious diseases in which, in most cases, the immune system was just doing "its thing." The major question in infectious diseases for the immunologist is to understand its limitations and compromises in an agent related fashion and to understand how infection contributes to the development of immunologic diseases. Consequently, they have included overviews of how the immune system deals with microbes rather than, in most cases, discussing each disease entity separately.
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Posted: November 15th, 2007, 8:50am CET by X
Martin Weyreuther, Christoph E. Heyde, Michael Westphal, Jan Zierski, Ulrich Weber,
"MRI Atlas: Orthopedics and NeurosurgeryThe Spine"Publisher:Springer | Pages:296 | 2006-10-31 | ISBN:3540335331 | PDF | 16.83 MB
The MRI Atlas of the Spine is the result of an interdisciplinary cooperation between radiologists, orhtopedists and traumatologists. All important diseases and injuries of the spine are covered. Synopsis: This MRI atlas of the spine is the fruit of interdisciplinary cooperation among radiologists, orthopedic surgeons, traumatologists, and neurosurgeons. It is a clinically oriented atlas that covers all important diseases and injuries of the spine. Ample illustrations are supplemented by concise descriptions of anatomy and pathophysiology, the normal and abnormal MRI appearance, diagnostic pitfalls, and the clinical significance of MRI. The clear and didactic style enables readers to revise the fundamentals of spinal anatomy and disease states as a basis for understanding the diagnostic strategies and surgical management. By combining descriptions of the clinical manifestation of spinal disorders with the corresponding MRI findings, the authors hope to help readers develop a meaningful approach to the interpretation of MRI of the spine.
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Posted: November 15th, 2007, 8:50am CET by X
Macrophages: A Practical ApproachOxford University Press | ISBN: 0199636885 | October 23, 2000 | PDF | 228 pages | 2.6 MB
Macrophages are an important part of the immune response and are characterized by their ability to phagocytose foreign matter. However the difficulties involved in macrophage isolation mean they are some of the body's least explored cells. Macrophage Methodology describes how to isolate moderate to high yields of viable cells from a variety of specific tissue sites under both normal and pathological conditions and then goes on to give protocols for macrophage purification. The third chapter covers techniques used to identify and measure endocytic and phagocytic capabilities using immunochemistry and fluorescent analysis. Chapter four identifies the key issues relating to the study of macrophages as antigen presenting cells and has protocols for the major assays used to measure antigen processing and presentation. Also covered are the theoretical and practical issues related to the processing and presentation of intracellular pathogens for which macrophages are the major host cell. The methods described for measuring macrophage secretory products concentrate on bioassays for molecules where no ELISA is available. The next two chapters cover measuring macrophage activity in vitro and in vivo. Finally methods are described for the analysis of gene expression in macrophages. A variety of broad techniques have been brought together in one affordable volume to make Macrophage Methodology an essential buy for anyone studying macrophages.
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Posted: November 15th, 2007, 8:49am CET by X
Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery (US$399)Stationary Office | Pages: 1048 | 2007-10-01 | ISBN: 3540200045 | 31 MB
Atlas of Upper Gastrointestinal and Hepato-Pancreato Biliary Surgery covers in detail the technical aspects of all important procedures of the upper abdomen (esophagus, duodenum, stomach, liver, biliary system, pancreas, portal hypertension and spleen) including general, oncologic and transplantation surgery. Each chapter has been written by an expert renowned in his or her field and been reviewed by a second expert. All of the approximately 900 illustrations have been drawn by the same team of three artists of notable experience. The liver section follows the internationally accepted terminology of the Brisbane 2000 conference of the IHPBA. In this atlas experts of upper abdominal surgery share their experience and show how they do it -- step by step.
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Posted: November 15th, 2007, 8:49am CET by X
"Surgical Wound Healing and Management"Publisher: Informa Healthcare | Pages: 176 | 2007-02-12 | ISBN: 0849382564 | PDF | 4.36 MB
Wound bed preparation can be defined as the process of removing dead tissue, debris, and contaminants from an injured site to facilitate healing and provide a more expedient means to patient recovery. This reference explores the critical role of surgery in wound bed preparation and management and provides a sound knowledge of wound mechanisms, physiology, and metabolic control. Founded on the expertise of internationally-recognized authorities, this source illustrates the many techniques utilized by surgeons to design optimal healing environments, maximize the efficacy of existing treatment modalities, and extract bacteria from a variety of wound situations resulting from burns, trauma, and disease.
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Posted: November 15th, 2007, 8:48am CET by X
Handbook of Parkinson's Disease, Fourth Edition (Neurological Disease and Therapy) (US$229.95)Stationary Office | Pages:500 | 2007-03-23 | ISBN: 0849376211 | 4 MB
This blue-ribbon guide has long prevailed as one of the leading resources on Parkinson's Disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this source promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies for PD.
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Posted: November 15th, 2007, 8:48am CET by X
Chronic Myeloid Leukemia (US$149.95)Stationary Office | Pages: 176 | 2006-12-13 | ISBN: 0849379555 | 3 MB
Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatment of CML and provides an authoritative and convenient summary of the latest progress in imatinib trials, the molecular monitoring of CML responses, and the engineering of new therapies to overcome resistance and improve patient care.
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Posted: November 15th, 2007, 8:47am CET by X
Molecular Nutrition and Genomics: Nutrition and the Ascent of Humankind Stationary Office | Pages: 140 | 2007-07-09 | ISBN: 0470081597 | 15 MB
This fascinating book draws it subject matter from a range of relevant disciplines that extend from molecular nutrition, nutritional sciences, and nutrition dietetics through to genetics, genomics, and anthropology. It presents a vital portrait of the absolutely fundamental role that nutrition has played and continues to play in shaping who and what human beings are, as well as where they evolved from, and where they may be heading as a species.
Molecular Nutrition: Nutrition and the Evolution of Humankind:
* Blends coverage of the molecular mechanisms that underpin nutrient-gene interactions with evolutionary theory
* Takes a molecular biological approach to problem solving, and moves nutrition away from its dietetic and anthropological origins to the front lines of genomic research
* Covers key concepts in molecular biology; the -omics revolution and bioinformatics; recent human evolution; molecular mechanisms of gene-nutrient interactions; the importance of nutrients and genomics in disease; the evolution of micronutrient metabolism, protein structure, and human disease; nutrients and the human lifecycle; contemporary dietary patterns; leading-edge laboratory tools in nutrigenomics and human evolutionary studies
Written by an internationally recognised expert in the field, Molecular Nutrition: Nutrition and the Evolution of Humankind is an invaluable text and reference book for a wide range of teachers, students, and researchers.
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Posted: November 15th, 2007, 8:47am CET by X
The Sperm Cell: Production, Maturation, Fertilization, Regeneration Stationary Office | Pages:372 | 2006-06-12 | ISBN: 0521853974 | 12 MB
This is a comprehensive and definitive account of the human male gamete. The volume summarizes many unique and revealing characteristics of the sperm cell that have only recently been identified. It provides a detailed overview of human sperm production, maturation and function, and looks at how these processes affect and influence fertility, infertility and ART. This is the first dedicated account of the sperm cell to be published in almost a decade. The volume thus provides a very timely review of the most recent research and developments, augmented with the latest references. This book will appeal to all practitioners and scientists in reproductive medicine and in particular to clinical scientists, graduate and post-graduate scientists, and laboratory personnel.
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Posted: November 15th, 2007, 8:46am CET by X
Molecular Mechanisms of Cancer (US$129)Stationary Office | Pages: 650 | 2006-10 | ISBN: 1402060157 | 13 MB
The knowledge of molecular defects that lead to cancer is increasing rapidly. This has created a need for a textbook that conveys a comprehensive review of this topic. "Molecular Mechanisms of Cancer", describes molecular processes whose deregulation is important in the formation of tumours. The material is developed from basic cell signalling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumour cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumour-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers. This book is an essential resource for researchers, graduate students and oncologists. It will also aid in drug discovery by identifying molecular targets. The growing insight generated by research into molecular carcinogenesis and the absence of comparably comprehensive and systematic textbooks makes this publication important and timely.
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Posted: November 15th, 2007, 8:46am CET by X
Bitter Nemesis: The Intimate History of Strychnine Stationary Office | Pages: 320 | 2007-07-16 | ISBN: 1420053159 | 5 MB
Encouraged by the medicinal success of quinine, early 19th century scientists hoped strychnine, another plant alkaloid with remarkable properties, might also become a new weapon against disease. Physicians tried for over a century, despite growing evidence to the contrary, to treat everything from paralysis to constipation with it. But strychnine proved only to be disappointingly deadly-relegating its fate almost entirely to animal control, the dangerous adulteration of foods, and criminal exploits. The NOTORIOUS and TRUE story of how a POISONOUS alkaloid... Bitter Nemesis: The Intimate History of Strychnine presents a scholarly and compelling history of this fascinating chemical substance from its discovery to present times. A renowned editor for the Dictionary of Natural Products, Dr. John Buckingham fuses his eclectic interests into an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics. ...Changed the course of HISTORY! Uncovering details and logistics from the earliest experiments performed in an era when proper scientific trials for testing new drugs were still in their infancy, the author explores strychnine's trial-and-error contributions to scientific, medical, and forensic developments. He also investigates historical milestones and the perception of strychnine in popular culture-including criminal notoriety, accidental misuse, and new claims of strychnine's benefits that extend through to the present day. Juxtaposing the real trials, mistrials, and persistent curiosity associated with one of history's most notorious pharmaceutical failures, Bitter Nemesis offers rare insight into the anarchic, yet inspired landscape, practices, and legacy of 19th century science.
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Posted: November 15th, 2007, 8:45am CET by X
Epidermal Growth Factor: Methods and ProtocolsHumana Press | 1934340X | Edition - 2005-12-15 | PDF | 224 pages | 1.5 MB
A comprehensive collection of optimized methods for dissecting the mechanisms that control epidermal growth factors (EGF) and their regulators in both normal and pathological states. These readily reproducible techniques range from the study of purified EGF receptor to complex signaling and processing networks in intact cells, including a chapter on the clinical and pharmacological considerations of their use in cancer therapy. The protocols follow the successful Methods in Molecular BiologyT series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
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